back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and UBE3B

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_569733.2	Gene:	UBE3B / 89910	HGNCID:	13478	Length:	1068	Species:	Homo sapiens

Alignment Length:	473	Identity:	96/473 - (20%)
Similarity:	164/473 - (34%)	Gaps:	147/473 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   812 NVLSSKFIPSFES-----------LDIPSTSAAAAAAAVAASNAPNP-GNNREESSDESTITS-- 862
            ::||.|.:.|.|.           |.:.|....|...:.:..|...| |..|.:|::...:.:
Human   400 DILSKKLLESQEPAHAQPASPQNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNIC 464

  Fly   863 --SQTS--TLTRNQAPCM-------ELQEQMAAELLGLGPLNE----PECSDDDDDDEEEELDDK 912
              .|||  |||:.:...:       :|..::.|.:..|||...    .||.::|.::.::.|...
Human   465 VLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAML 529

  Fly   913 QLVSDVG-----------------------LMNSSSMLHAYLQNMKQEFADKETNTDRAYLPEKS 954
            .|..|..                       |:..||.|::::..|..:...:....:...|.:..
Human   530 MLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSV 594

  Fly   955 RGQSQLMDDRPVKRSQTFTPSEAFSKNRYN-----CRLNRSDSDSAMHCGVAPHTFQRGAAERRS 1014
            .|...::.:|..:|  .|||.:.:.:....     ..|:|....:.:.....||....   :.|.
Human   595 HGWLMVLYERDCRR--RFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPH---KNRV 654

  Fly  1015 LRFHSKAPKSVTKL----------HHTHIP-RTSLDLE-----LDLQAQHS-----KLYFLN--- 1055
            |.|.:...|...||          |.|||. |.|..||     |...:||:     ::.|:|
Human   655 LLFRTMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLG 719

  Fly  1056 --------DQIAKLQNLKEVLQKACENKDPLVAAWAIENEEFQRLVARADPAKCPEERQLQ---- 1108
                    |.:.| :.|:|::::..   ||.:..:...:.: :||.  ..|.....|..||
Human   720 VDEAGIDQDGVFK-EFLEEIIKRVF---DPALNLFKTTSGD-ERLY--PSPTSYIHENYLQLFEF 777

  Fly  1109 --KLLMKTAKEIHKLRKTKVPKGCPDLVSFKEKITFFTRKGL---------SVPELPSEFTLPEA 1162
              |:|.|...|           |....|.|   .:||..:.|         ||.||||.
Human   778 VGKMLGKAVYE-----------GIVVDVPF---ASFFLSQLLGHHHSVFYSSVDELPSL------ 822

  Fly  1163 NPIEEEEEEEDENEFYNS 1180
                       ::|||.:
Human   823 -----------DSEFYKN 829

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.