DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and HUL5

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_011374.1	Gene:	HUL5 / 852736	SGDID:	S000003109	Length:	910	Species:	Saccharomyces cerevisiae

Alignment Length:	568	Identity:	107/568 - (18%)
Similarity:	191/568 - (33%)	Gaps:	217/568 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 QTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLEN 157
            :|:..|     ..|.:::....:.|.:.||:|.|....|.....|..::..:.:.::...:.:.:
Yeast   229 KTYSHC-----SKGGQKNIAKLLIPNFNNHIAPSVLRSDNDYVLKFYEKAFIDEVIATTANYVSD 288

  Fly   158 KREMFDVKQQRLLWAQEEYNHLK-----LAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQL 217
            :                  :|:|     :|:|.:..|.:|..::          |:..::.|.:|
Yeast   289 E------------------DHVKNLMCYIASSPNQSCKNSVLIT----------LLSNKDFVRRL 325

  Fly   218 KQELTHITNDISYTERGMNTLYSVGEKINARENGCYDIAEVHAIREEMLKVHKSLVSGEKV--RE 280
            ..|..|...:.|.||  .:.|:||          ...:.::|.    ::...:.|:....|  .|
Yeast   326 SWEFFHTKFNASKTE--AHPLFSV----------LAQLIDMHL----LISTDRELLDYNSVIPIE 374

  Fly   281 ELMRSLVQIKNELGRQ----QISEENSDL--ASPFDRVCVASQTDLCGSSGEN------------ 327
            ||.:....:|:...||    ..||.|..|  |.|.........:.|...|.||
Yeast   375 ELKKFTSTLKDFTFRQYWELPKSERNPMLKEAVPLLSKVYERDSRLHFLSTENNPTYWENSEKQF 439

  Fly   328 LNGGARFAEMAKTKWQYAE-WRKHIKKLQQQLADHVERIEPGQLESDKDR----ILLIQEKEKLL 387
            ||  .||.|..:   :|.: :|:|   |:::..:.:|:    :::.||:|    .||:.:.:|.|
Yeast   440 LN--LRFYEELQ---EYEDLYREH---LEEESDEDMEK----EIDLDKERPPLKSLLLNKMKKRL 492

  Fly   388 NDLNSISLKSRSEE-----------EKRV--------IHQTRHKLEED----------------- 416
            ..    ||:.|..|           |:||        :.:.|..|::|
Yeast   493 KS----SLRFRKLEILLELPFFIPFEERVDLFYMFIALDKKRLSLDDDHNLINMFTPWASTGMRK 553

  Fly   417 ----------LKEAYEANNTCVANRLR----------FHEE---------KQLLLDKLQEALK-- 450
                      |::|:.|.|: :..|.:          |.||         |:.|.....|..|
Yeast   554 QSAIISRDNVLEDAFNAFNS-IGERFKASLDVTFINEFGEEAGIDGGGITKEFLTTVSDEGFKDP 617

  Fly   451 --------------------STKL-------------LEER-----------LKSFSSESTFSIS 471
                                :|||             |.|.           ||...:.|...:|
Yeast   618 KHELFRTNDRYELYPSVVYDATKLKYIWFLGKVVGKCLYEHVLIDVSFADFFLKKLLNYSNGFLS 682

  Fly   472 SGSSLGSLSTASSKSALSFTDIYID-------PFAVDSP---IDVVDL 509
            |.|.|||..:....:.:...::..|       .|.:|.|   ..||||
Yeast   683 SFSDLGSYDSVLYNNLIKLLNMTTDEIKSLDLTFEIDEPESSAKVVDL 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809	6/28 (21%)
		C2_Kibra	693..813	CDD:176062
HUL5	NP_011374.1	HUL4	35..910	CDD:227354	107/568 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900