DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and GAS7

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_958839.1	Gene:	GAS7 / 8522	HGNCID:	4169	Length:	476	Species:	Homo sapiens

Alignment Length:	503	Identity:	89/503 - (17%)
Similarity:	178/503 - (35%)	Gaps:	139/503 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYI 120
            ||.||.......|:.||::....:|||..|......|.:         |.....|..|.:..|:
Human    79 LPPGWQSYLSPQGRRYYVNTTTNETTWERPSSSPGIPAS---------PGSHRSSLPPTVNGYH- 133

  Fly   121 NHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASR 185
               |..|....|.....:|:                                       |.....
Human   134 ---ASGTPAHPPETAHMSVR---------------------------------------KSTGDS 156

  Fly   186 SSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSVGEKINAREN 250
            .:|.|||.|..:.....:..:.:.........:|:|...| :.||.:      |...:|.:.:.|
Human   157 QNLGSSSPSKKQSKENTITINCVTFPHPDTMPEQQLLKPT-EWSYCD------YFWADKKDPQGN 214

  Fly   251 GCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVA 315
            |  .:|....:.::.||       |:::::|:...:.:      |.:|.|:.:...:...:..:|
Human   215 G--TVAGFELLLQKQLK-------GKQMQKEMSEFIRE------RIKIEEDYAKNLAKLSQNSLA 264

  Fly   316 SQTDLCGSSGE---------------NLNGGARF-AEMAKTKWQYAE-WRKHIKKLQQQLAD--- 360
            ||.:  ||.||               :|...|:. :|:.|....:.| ::|.:||....:||
Human   265 SQEE--GSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRK 327

  Fly   361 -------HVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLK 418
                   .||:......|..:|..:..|:.|        |.|.:::||:.:...:...:..:||.
Human   328 QLASRYASVEKARKALTERQRDLEMKTQQLE--------IKLSNKTEEDIKKARRKSTQAGDDLM 384

  Fly   419 EAYEANNTCVANRLRFHEE---KQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSLS 480
            ...:..|..   :.::.||   ..|.|::|:  ::..:::.:.|..::     .:...:.:.:.|
Human   385 RCVDLYNQA---QSKWFEEMVTTTLELERLE--VERVEMIRQHLCQYT-----QLRHETDMFNQS 439

  Fly   481 TASSKSALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQHQQQRLHPV 528
            |             ::|  ||..:..||..:..:...::|:...:.||
Human   440 T-------------VEP--VDQLLRKVDPAKDRELWVREHKTGNIRPV 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	10/29 (34%)
		WW	103..132	CDD:278809	6/28 (21%)
		C2_Kibra	693..813	CDD:176062
GAS7	NP_958839.1	SH3_GAS7	5..57	CDD:212763
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..171		19/122 (16%)
		WW_FCH_linker	109..201	CDD:374680	19/144 (13%)
		F-BAR_GAS7	214..446	CDD:153333	50/281 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900