DRSC/TRiP Functional Genomics Resources

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Protein Alignment kibra and WWC2

DIOPT Version :9

Sequence 1:NP_001034055.1 Gene:kibra / 41783 FlyBaseID:FBgn0262127 Length:1288 Species:Drosophila melanogaster
Sequence 2:XP_011530571.1 Gene:WWC2 / 80014 HGNCID:24148 Length:1216 Species:Homo sapiens


Alignment Length:1267 Identity:409/1267 - (32%)
Similarity:636/1267 - (50%) Gaps:228/1267 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 PLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYY 119
            |||.||:.|:|:|||.:||||..::|:|:||||..|||.:|.||||||||.|||..:||.||.||
Human    11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQIGVYY 75

  Fly   120 INHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHL----- 179
            |:|:.::||:||||::|:..||:||.||||.|||.|..::|::.||:|||..|.:||..|     
Human    76 IDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQRLALALDEYVRLNDAYK 140

  Fly   180 KLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSVGEK 244
            :.::|.:||.|.|||.:::||::|:|::...|.||.:||:||:.:..::.|.|:|..||..:.:|
Human   141 EKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQELLYKEQGFETLQQIDKK 205

  Fly   245 INARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIK------NELGRQQ----IS 299
            ::..::| |:::|..||..|:..:.|::.||||.:::||:||.:::      ..:||.:    .|
Human   206 MSGGQSG-YELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERFHLDQNIGRSEPDLRCS 269

  Fly   300 EENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVER 364
            ..||.|......:...|||.:.|..|  :...:..||..:...||.|.::.:..|:.:|:.....
Human   270 PVNSHLCLSRQTLDAGSQTSISGDIG--VRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLDSE 332

  Fly   365 IEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVA 429
            ..||.|:.:|::::||.|||:||.:|..::.:.|:::|...:...|.:|||:|.......:..:|
Human   333 AWPGALDIEKEKLMLINEKEELLKELQFVTPQKRTQDELERLEAERQRLEEELLSVRGTPSRALA 397

  Fly   430 NRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSL---------STASSK 485
            .|||..|.::.||.||:|..|.|..|..:|||.|: ||.|:|||||||||         |:..|.
Human   398 ERLRLEERRKELLQKLEETTKLTTYLHSQLKSLSA-STLSMSSGSSLGSLASSRGSLNTSSRGSL 461

  Fly   486 SALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQHQQQRLHP------VH--------------- 529
            ::||.|::|     ..|..|.:|:..:.:..|...::....|      :|               
Human   462 NSLSSTELY-----YSSQSDQIDVDYQYKLDFLLQEKSGYIPSGPITTIHENEVVKSPSQPGQSG 521

  Fly   530 ------------PVLQQQQSAEVTLSPRSSLSMETPPASPM----------KYNAGADQTPQALK 572
                        |.|.:...:..:||.|||||..:||.||:          .::|...|      
Human   522 LCGVAAAATGHTPPLAEAPKSVASLSSRSSLSSLSPPGSPLVLEGTFPMSSSHDASLHQ------ 580

  Fly   573 EEPTYANALPAPPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKL----------QKLNMGTP 627
                          :||.         ....:|.|...|..::|.::          |.|:....
Human   581 --------------FTAD---------FEDCELSSHFADISLIENQILLDSDSGGASQSLSEDKD 622

  Fly   628 LNLAVAPLSPISEKPSLLD--LPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEA-------- 682
            ||....  .|:.|..:.::  ||:..:..... ..|..||||||:|||||||||:||        
Human   623 LNECAR--EPLYEGTADVEKSLPKRRVIHLLG-EKTTCVSAAVSDESVAGDSGVYEAFVKQPSEM 684

  Fly   683 -----SRAHLPRKELAQVQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSL 742
                 |...:...|.|||||||:|..:....:|.:.:..||.|.  .....|:||.|.|:||:| 
Human   685 EDVTYSEEDVAIVETAQVQIGLRYNAKSSSFMVIIAQLRNLHAF--LIPHTSKVYFRVAVLPSS- 746

  Fly   743 TSI----RTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMT-GQKEEIIGTVQISMAE-- 800
            |.:    |||.....:..:|||.|.|.|:...|..|:|:|.:.::: .::||.:...|||:|:  
Human   747 TDVSCLFRTKVHPPTESILFNDVFRVAISQTALQQKTLRVDLCSVSKHRREECLAGTQISLADLP 811

  Fly   801 FNPEDSTLKWYNVLSSKFIPS-----------------FESLDIPSTSA--AAAAAAVAASNAPN 846
            |:.|..|| |||:|.||.:|.                 .:|:|:.:.||  |..:|.:.|.....
Human   812 FSSEVFTL-WYNLLPSKQMPCKKNEENEDSVFQPNQPLVDSIDLDAVSALLARTSAELLAVEQEL 875

  Fly   847 PGNNREESSDESTITSSQTSTLTRNQAPCMELQEQMAAELLGLGPLNE--PECSDDDDDDEEEEL 909
            .....|||..|.. .......|......|.||::.:...|. :.||..  .|.||:...::|.|:
Human   876 AQEEEEESGQEEP-RGPDGDWLNTYFLCCWELKDDVFTRLT-VKPLLTMLREASDEIVAEKEAEV 938

  Fly   910 ---------DDKQLVSDVGLMNSSSMLHAYLQNMKQE----------------FADKETNTDR-- 947
                     :|....:.|..||...       |.|:.                ..|||||||.  
Human   939 KLPEDSSCTEDLSSCTSVPEMNEDG-------NRKESNCAKDLRSQPPTRIPTLVDKETNTDEAA 996

  Fly   948 ----AYLPEK----SRGQSQLMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHT 1004
                |..|::    |..|...:....:.|||||:|.|   :|:|.||||||||||:.   :|..:
Human   997 NDNMAVRPKERSSLSSRQHPFVRSSVIVRSQTFSPGE---RNQYICRLNRSDSDSST---LAKKS 1055

  Fly  1005 -FQRGAAERRSLRFHSKAPKSVTKLHHTHIP-RTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEV 1067
             |.|.:.||||||......:||.:......| ||||||||||||..::...|||::..|::|::.
Human  1056 LFVRNSTERRSLRVKRTVCQSVLRRTTQECPVRTSLDLELDLQASLTRQSRLNDELQALRDLRQK 1120

  Fly  1068 LQKACENKDPLVAAWAIENEEFQRLVARAD-PAKCPEERQLQ-----KLLMKTAKEIHKLRK--T 1124
            |::.....:..:....:|:|.||||:.:|: .|:..:|.|.|     ||:.:.:|::.:||:  .
Human  1121 LEELKAQGETDLPPGVLEDERFQRLLKQAEKQAEQSKEEQKQGLNAEKLMRQVSKDVCRLREQSQ 1185

  Fly  1125 KVPKGCPDLVSFKEKITFFTRKGLSVPELPSE 1156
            |||:   .:.||:|||.:|||..:|:|.||::
Human  1186 KVPR---QVQSFREKIAYFTRAKISIPSLPAD 1214

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kibraNP_001034055.1 WW 57..87 CDD:238122 16/29 (55%)
WW 103..132 CDD:278809 16/28 (57%)
C2_Kibra 693..813 CDD:176062 46/126 (37%)
WWC2XP_011530571.1 WW 12..41 CDD:278809 15/28 (54%)
WW 59..88 CDD:278809 16/28 (57%)
DUF342 <283..385 CDD:302792 30/103 (29%)
YlqD 351..>428 CDD:287979 25/76 (33%)
C2_Kibra 700..823 CDD:176062 46/126 (37%)
vWFA <1058..>1153 CDD:294047 35/94 (37%)
Phage_Nu1 <1117..1192 CDD:294991 21/77 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156962
Domainoid 1 1.000 262 1.000 Domainoid score I1950
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 542 1.000 Inparanoid score I1181
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG50236
OrthoDB 1 1.010 - - D181722at33208
OrthoFinder 1 1.000 - - FOG0003726
OrthoInspector 1 1.000 - - otm41793
orthoMCL 1 0.900 - - OOG6_103792
Panther 1 1.100 - - O PTHR14791
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4620
SonicParanoid 1 1.000 - - X1418
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.800

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