DRSC/TRiP Functional Genomics Resources

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Protein Alignment kibra and HECTD3

DIOPT Version :9

Sequence 1:NP_001034055.1 Gene:kibra / 41783 FlyBaseID:FBgn0262127 Length:1288 Species:Drosophila melanogaster
Sequence 2:NP_078878.3 Gene:HECTD3 / 79654 HGNCID:26117 Length:861 Species:Homo sapiens


Alignment Length:924 Identity:163/924 - (17%)
Similarity:270/924 - (29%) Gaps:331/924 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   234 GMNTLYSVGEKINARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQI 298
            |...|.:..:.|..|...|     |....||:...|...|                  :|.::|:
Human    85 GSGPLRAARDSIELRRGAC-----VRTTGEELCNGHGLWV------------------KLTKEQL 126

  Fly   299 SEENSD--LASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQL--- 358
            :|...|  |...:..||..::            ||||...:        :...|::: ||||   
Human   127 AEHLGDCGLQEGWLLVCRPAE------------GGARLVPI--------DTPNHLQR-QQQLFGV 170

  Fly   359 ------------------------------ADHVERI----EPGQLESDKDRILLI-----QEKE 384
                                          |:.|:|:    .....|.|:|.|..:     :|.|
Human   171 DYRPVLRWEQVVDLTYSHRLGSRPQPAEAYAEAVQRLLYVPPTWTYECDEDLIHFLYDHLGKEDE 235

  Fly   385 KL---LNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQ 446
            .|   ...:.||.:.|.:||     .......:.:....:|::.:...:.:|...:|..::.||.
Human   236 NLGSVKQYVESIDVSSYTEE-----FNVSCLTDSNADTYWESDGSQCQHWVRLTMKKGTIVKKLL 295

  Fly   447 EALKST--KLLEERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDPFAVDSPI----- 504
            ..:.:|  ..:.:|:..:..|       |.:|..||..|....|......::...|..||     
Human   296 LTVDTTDDNFMPKRVVVYGGE-------GDNLKKLSDVSIDETLIGDVCVLEDMTVHLPIIEIRI 353

  Fly   505 -----DVVDLRRRSQRLFQQHQQ-----------------------------------QR----- 524
                 |.:|:|.|..::....|:                                   ||     
Human   354 VECRDDGIDVRLRGVKIKSSRQRELGLNADLFQPTSLVRYPRLEGTDPEVLYRRAVLLQRFIKIL 418

  Fly   525 ---LHPVHPV-------------------------------LQQQQSAEVTLSPR----SSLSME 551
               ||.:.|.                               |:..:|::.:..||    ..|:||
Human   419 DSVLHHLVPAWDHTLGTFSEIKQVKQFLLLSRQRPGLVAQCLRDSESSKPSFMPRLYINRRLAME 483

  Fly   552 ---TPPASPMKYNAGADQTPQALKEEPTYANALPAPPAYTAPPPVPISGVRARPYDLDSTVLDCM 613
               .|...|...||...|..:.||....|..    |..|..|          ..||   ...:|.
Human   484 HRACPSRDPACKNAVFTQVYEGLKPSDKYEK----PLDYRWP----------MRYD---QWWECK 531

  Fly   614 MLEAKLQKLNMGTPLNLAVAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSG 678
            .:...:  ::.|...            :.||.|:.:|:...|:.|..........:|:.    :|
Human   532 FIAEGI--IDQGGGF------------RDSLADMSEELCPSSADTPVPLPFFVRTANQG----NG 578

  Fly   679 VFEASRAHLPRKELAQVQIGLKYLKQE--GVLVVSLERANNLLALWTASADNSQVYLRAALLPNS 741
            ..||...::|......      :.|.|  |.|:.:..|....|.|                   :
Human   579 TGEARDMYVPNPSCRD------FAKYEWIGQLMGAALRGKEFLVL-------------------A 618

  Fly   742 LTSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPEDS 806
            |.....|.|...:.....|..||    |.:|.|.|:|    |.|..:|   |.:.   :|..|  
Human   619 LPGFVWKQLSGEEVSWSKDFPAV----DSVLVKLLEV----MEGMDKE---TFEF---KFGKE-- 667

  Fly   807 TLKWYNVLSS----KFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQTST 867
             |.:..|||.    :.||....:.:.....:.....|..:..       |||.::          
Human   668 -LTFTTVLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQKARL-------EESKEQ---------- 714

  Fly   868 LTRNQAPCMELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSSMLHAYLQ 932
            :...||..:::..|...:||....|.:..|.     |.|..:|..:.::.......|.....|..
Human   715 VAAMQAGLLKVVPQAVLDLLTWQELEKKVCG-----DPEVTVDALRKLTRFEDFEPSDSRVQYFW 774

  Fly   933 NMKQEFADKETNTDRAYLPEKSRGQSQL------------------MDDRPVKRSQTFTPSEAFS 979
            .....|    ||.||:.......|:|:|                  :.:.....|..|.|..|.:
Human   775 EALNNF----TNEDRSRFLRFVTGRSRLPARIYIYPDKLGYETTDALPESSTCSSTLFLPHYASA 835

  Fly   980 K--------NRYNC 985
            |        ..|||
Human   836 KVCEEKLRYAAYNC 849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kibraNP_001034055.1 WW 57..87 CDD:238122
WW 103..132 CDD:278809
C2_Kibra 693..813 CDD:176062 25/121 (21%)
HECTD3NP_078878.3 APC10-HECTD3 238..371 CDD:176487 26/144 (18%)
HECT 579..845 CDD:366212 62/333 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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