DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and herc5.2

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_005160175.1	Gene:	herc5.2 / 794323	ZFINID:	ZDB-GENE-090311-16	Length:	987	Species:	Danio rerio

Alignment Length:	249	Identity:	54/249 - (21%)
Similarity:	97/249 - (38%)	Gaps:	72/249 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   846 NPGNNREESSDESTITSSQTSTLTRNQA------------PCM--ELQEQMAAELLGLGPLNEPE 896
            ||||  |.:..:|::..   ..||.|..            |.:  |:::..::.:...|...:|.
Zfish   351 NPGN--ESTKPKSSMNG---GILTLNDRMIDRWVSGSYPWPTVKKEIKKVFSSAVCLNGSFLKPS 410

  Fly   897 CSDDDDD----DEEEELDDKQLVSDVGLMNSSSMLHAYLQNMKQEFADKETNTDRAYLPEKSRGQ 957
            ..:.|.|    ...:..|:::::|:|..:...::    |.::..:.|.:|:......|||..:|.
Zfish   411 LDEQDFDLVGKSFSKLTDNEKVISEVVKVIQQTL----LPSLNPKPAHEESLRLYLLLPELIKGL 471

  Fly   958 SQLMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHTFQRGAAERRSLR-FHSKA 1021
            .|      .:||:                ||::         :|....|..:|.|..|. |.||.
Zfish   472 EQ------YQRSE----------------LNKA---------LASKILQLNSAAREMLEMFWSKL 505

  Fly  1022 P----KSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKA 1071
            |    ||:.||.|    :.|.||     ..:..:..::..:..||||..:||.|
Zfish   506 PDDWLKSLVKLFH----KESADL-----IDYMSVCAMDSDLKHLQNLLRILQMA 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809
		C2_Kibra	693..813	CDD:176062
herc5.2	XP_005160175.1	RCC1_2	120..149	CDD:290274
		RCC1	136..186	CDD:278826
		RCC1	189..238	CDD:278826
		RCC1	242..290	CDD:278826
		RCC1	296..347	CDD:278826
		HECTc	649..985	CDD:294058
		HECTc	678..984	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900