DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and Hectd3

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_780453.1	Gene:	Hectd3 / 76608	MGIID:	1923858	Length:	861	Species:	Mus musculus

Alignment Length:	923	Identity:	162/923 - (17%)
Similarity:	270/923 - (29%)	Gaps:	329/923 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 GMNTLYSVGEKINARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQI 298
            |...|.:..:.|..|...|     |....||:...|...|                  :|.::|:
Mouse    85 GSGPLRAARDSIELRRGAC-----VRTTGEELCNGHGLWV------------------KLTKEQL 126

  Fly   299 SEENSD--LASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQ----- 356
            :|..||  |...:..||..::            ||||...:        :...|:::.||
Mouse   127 AEHLSDCSLDEGWLLVCRPAE------------GGARLVPI--------DTPDHLQRQQQLFGVD 171

  Fly   357 --------QLADHV------ERIEPGQ-----------------LESDKDRILLI-----QEKEK 385
                    |:.|..      .|.:|.:                 .|.|:|.|..:     :|.|.
Mouse   172 YRPVLRWEQVVDLTYSHRLGSRPQPAEAYTEAIQRLLYVPPTWTYECDEDLIHFLYDHLGKEDEN 236

  Fly   386 L---LNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQE 447
            |   ...:.||.:.|.:||     .......:.:....:|::.:...:.:|...:|..::.||..
Mouse   237 LGSVKQYVESIDVSSYTEE-----FNVSCLTDSNADTYWESDGSQCQHWVRLTMKKGTIVKKLLL 296

  Fly   448 ALKST--KLLEERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDPFAVDSPI------ 504
            .:.:|  ..:.:|:..:..|       |.:|..||..:....|......::...|..||
Mouse   297 TVDTTDDNFMPKRVVVYGGE-------GDNLKKLSDVNIDETLIGDVCVLEDMTVHLPIIEIRIV 354

  Fly   505 ----DVVDLRRRSQRLFQQHQQ-----------------------------------QR------ 524
                |.:|:|.|..::....|:                                   ||
Mouse   355 ECRDDGIDVRLRGVKIKSSRQRELGLNADLFQPASLVRYPRLEGTDPEVLYRRAVLLQRFIKILD 419

  Fly   525 --LHPVHPV-------------------------------LQQQQSAEVTLSPR----SSLSME- 551
              ||.:.|.                               |:..:|::.:..||    ..|:||
Mouse   420 SVLHHLVPAWDHTLGTFSEIKQVKQFLLLSRQRPSLVAQCLRDSESSKPSFMPRLYINRRLAMEH 484

  Fly   552 --TPPASPMKYNAGADQTPQALKEEPTYANALPAPPAYTAPPPVPISGVRARPYDLDSTVLDCMM 614
              .|...|...||...|..:.||....|..    |..|..|          ..||   ...:|..
Mouse   485 RACPSRDPACKNAVFTQVYEGLKPSDKYEK----PLDYRWP----------MRYD---QWWECKF 532

  Fly   615 LEAKLQKLNMGTPLNLAVAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGV 679
            :...:  ::.|...            :.||.|:.:|:...|:.|..........:|:.    :|.
Mouse   533 IAEGI--IDQGGGF------------RDSLADMSEELCPSSADTPVPLPFFVRTANQG----NGT 579

  Fly   680 FEASRAHLPRKELAQVQIGLKYLKQE--GVLVVSLERANNLLALWTASADNSQVYLRAALLPNSL 742
            .||...::|......      :.|.|  |.|:.:..|....|.|                   :|
Mouse   580 GEARDMYVPNPSCRD------FAKYEWIGQLMGAALRGKEFLVL-------------------AL 619

  Fly   743 TSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPEDST 807
            .....|.|...:.....|..||    |.:|.|.|:|    |.|..:|   |.:.   :|..|
Mouse   620 PGFVWKQLSGEEVSWSKDFPAV----DSVLVKLLEV----MEGVDKE---TFEF---KFGKE--- 667

  Fly   808 LKWYNVLSS----KFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQTSTL 868
            |.:..|||.    :.||....:.:.....:.....|..:..       |||.::          :
Mouse   668 LTFTTVLSDQQVVELIPGGTGIVVEYEDRSRFIQLVRKARL-------EESKEQ----------V 715

  Fly   869 TRNQAPCMELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSSMLHAYLQN 933
            ...||..:::..|...:||....|.:..|.     |.|..:|..:.::.......|.....|...
Mouse   716 AAMQAGLLKVVPQAVLDLLTWQELEKKVCG-----DPEVTVDALRKLTRFEDFEPSDTRVQYFWE 775

  Fly   934 MKQEFADKETNTDRAYLPEKSRGQSQL------------------MDDRPVKRSQTFTPSEAFSK 980
            ....|    ||.||:.......|:|:|                  :.:.....|..|.|..|.:|
Mouse   776 ALNNF----TNEDRSRFLRFVTGRSRLPARIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAK 836

  Fly   981 --------NRYNC 985
                    ..|||
Mouse   837 VCEEKLRYAAYNC 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809
		C2_Kibra	693..813	CDD:176062	25/121 (21%)
Hectd3	NP_780453.1	APC10-HECTD3	238..371	CDD:176487	25/144 (17%)
		HECTc	528..849	CDD:214523	73/406 (18%)
		HECT	586..845	CDD:279026	60/326 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900