Protein Alignment kibra and Wwp2

DIOPT Version :9

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_080106.1
• Gene: Wwp2 / 66894
• MGIID: 1914144
• Length: 870
• Species: Mus musculus
• Alignment Length: 495
• Identity: 96/495 - (19%)
• Similarity: 170/495 - (34%)
• Gaps: 152/495 - (30%)

  Fly     5 QQTASQSQHHLHPHHLRPQ--QQQQQHHHHHQQQQQQQHTHHQQQQQHHSD-------------- 53
            ::|..:.:.:...|:.|..  |:....:..:.:|.|.|....|...||.|.
Mouse   338 KRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHD 402

  Fly    54 --FPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIG 116
              .|||.||:..:| :|:.||::|..:.|.|.|||   |:....|..    ||.|||..|.....
Mouse   403 PLGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPR---TQGMIQEPA----LPPGWEMKYTSEGV 459

  Fly   117 PYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEY----- 176
            .|:::|..::|..:|||..:::..:|              .....:|   :...|...::
Mouse   460 RYFVDHNTRTTTFKDPRPGFESGTKQ--------------GSPGAYD---RSFRWKYHQFRFLCH 507

  Fly   177 -----NHLKLAASRSSLCSSS----SSMSRHDPELLRADLM-------------LARERVHQLKQ 219
                 :|:|::.||.:|...|    .:|..:|   ||..|.             :|||....|..
Mouse   508 SNALPSHVKISVSRQTLFEDSFQQIMNMKPYD---LRRRLYIIMRGEEGLDYGGIAREWFFLLSH 569

  Fly   220 ELTHITNDISYTERGMNTLYSVGEKINARENGCYDIAEVHAIR---------------------- 262
            |:             :|.:|.:.| ...:.|.|..|....:|.
Mouse   570 EV-------------LNPMYCLFE-YAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGK 620

  Fly   263 -----------EEMLKVHKSLVSGEKVREELMRSLVQIK----NELGRQQISEENSDLASPFDRV 312
                       :.||....:|...|.:..|...|:|.||    .|.|.:....::.::....
Mouse   621 FIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELFFIQDMEILGKV--- 682

  Fly   313 CVASQTDLCGSSGENLNGGARFAEMAKTKWQY----AEWR--KHIKKLQQQLADHVERIEPGQLE 371
                      ::.|...||.......:.|.:|    .:||  :.:::..:...|....:.|.:..
Mouse   683 ----------TTHELKEGGENIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWL 737

  Fly   372 SDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRH 411
            ...|.    :|.|.:|..:..|.:   |:.:|..|:  ||
Mouse   738 RYFDE----KELELMLCGMQEIDM---SDWQKNAIY--RH 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	12/29 (41%)
		WW	103..132	CDD:278809	9/28 (32%)
		C2_Kibra	693..813	CDD:176062
Wwp2	NP_080106.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988
		PRK07003	<149..>299	CDD:235906
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	150..300
		WW	302..331	CDD:366073
		WW	332..361	CDD:366073	4/22 (18%)
		WW	407..435	CDD:366073	11/28 (39%)
		WW	447..477	CDD:238122	10/29 (34%)
		HECTc	516..868	CDD:238033	52/292 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900