Protein Alignment kibra and SMURF2

DIOPT Version :10

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_047292502.1
• Gene: SMURF2 / 64750
• HGNCID: 16809
• Length: 750
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 108/538 - (20%)
• Similarity: 188/538 - (34%)
• Gaps: 151/538 - (28%)

  Fly    37 QQQQHTHHQQQQQHHSDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGD 101
            :.|:|.::..:...|:...||:|::......|:.|::......:||.|||    .|:...:...:
Human   236 RSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPR----VPRDLSNINCE 296

  Fly   102 E---LPMGWEESYDPNIGPYYINHLAQSTQLEDPR---------QEWKTVQEQMLSDYLSAAQDQ 154
            |   ||.|||.........|:::|..::||..|||         .....:::|.....:|...|.
Human   297 ELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDD 361

  Fly   155 LE------NKREM---FDVKQQRLLWAQEEYNHLKLAASRSSLCSSS-SSMSRHDPELLRADLML 209
            .|      .||::   ..:.:|.|...|.:..|.::..||..:...| ..:.:..|:.|...||:
Human   362 TECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMI 426

  Fly   210 -------------ARERVHQLKQELTH-----------------ITNDISYTERGMNTLYSVGEK 244
                         |||.::.|..|:.:                 |..|.:.....::..:.||..
Human   427 KFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRI 491

  Fly   245 IN-ARENGCY-DIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDLAS 307
            :. |..:|.| |........:::|....:|...|.|..:|..|||.|.          || |:..
Human   492 MGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWIL----------EN-DITG 545

  Fly   308 PFDRV-CVASQTDLCGSSGENLN-----GGARFAEMAKTKWQ----YAEWRKHIKKLQQQ---LA 359
            ..|.. ||..     .:.||.:.     .|.......:.|.:    |..|| .::.::.|   |.
Human   546 VLDHTFCVEH-----NAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWR-FLRGIEAQFLALQ 604

  Fly   360 DHVERIEPGQL---ESDKDRILLIQEKEKLLNDLNSISLKSR--------------------SEE 401
            .....:.|..|   ..:|:..|:|....|:  |:|...:.:|                    .:|
Human   605 KGFNEVIPQHLLKTFDEKELELIICGLGKI--DVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDE 667

  Fly   402 EKR------------------------------VIHQTRHKLEEDLKEAYEANNTCVANRLRF-- 434
            |:|                              .|||. .....:|.:|:    ||. ||:..
Human   668 ERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQI-DACTNNLPKAH----TCF-NRIDIPP 726

  Fly   435 HEEKQLLLDKLQEALKST 452
            :|..:.|.:||..|::.|
Human   727 YESYEKLYEKLLTAIEET 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	8/29 (28%)
		WW	103..132	CDD:459800	9/28 (32%)
		C2_Kibra	693..813	CDD:176062
SMURF2	XP_047292502.1	C2_Smurf-like	19..139	CDD:176028
		HUL4	<161..747	CDD:227354	108/538 (20%)