DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and Huwe1

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_006528996.1	Gene:	Huwe1 / 59026	MGIID:	1926884	Length:	4456	Species:	Mus musculus

Alignment Length:	1496	Identity:	286/1496 - (19%)
Similarity:	489/1496 - (32%)	Gaps:	457/1496 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QTASQ--SQHHLHPHHLRPQQQQQQHHHHHQQQQQ--------------------QQHTHHQQQQ 48
            |.|||  |.|...|.  .|.:.:.|...|...|.:                    |......|:.
Mouse  2359 QGASQDSSSHQQDPG--EPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQEM 2421

  Fly    49 QHHSDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDP 113
            |..::  |.|..|...:.||.       :..:|.:..|....:.|  ||.:.||.|
Mouse  2422 QVENE--LEDLIDELLERDGG-------SGNSTIIVSRSGEDESQ--EDVLMDEAP--------- 2466

  Fly   114 NIGPYYINHLAQSTQLE----------DPRQEWKTVQEQMLS---DYLSAAQDQLENKREMFDVK 165
                   ::|:|::.|:          ||..|.:..||:..|   :....:||:.|.:.|..:..
Mouse  2467 -------SNLSQASTLQANREDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDD 2524

  Fly   166 QQ---------------RLLWAQEEYNHLK---------------LAASRSSLCSSSSSMSRHDP 200
            |:               ..:...|:|..:.               |.....::.||::.:.....
Mouse  2525 QEDDEGEEGDEDDDDDGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPG 2589

  Fly   201 ELLRADLMLARERVHQ-----LKQELTHITNDISYTERGMNTL-YSVGEKINARENGCYDIAEVH 259
            .:.....::.|...|.     .....|.:|..|..::|.:..| .:.|..|:....|
Mouse  2590 NIPTTHPLMVRHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPG-------- 2646

  Fly   260 AIREEMLKVHKSLVSGEKVREELMRSLVQIKNEL-----GRQQISEENSDLASPFDRVCVASQTD 319
                 ..:.:..|:....:.......::|:.:.|     ||.::...|.|:     .:...|..:
Mouse  2647 -----NRQPNPPLILQRLLGPSAAADILQLSSSLPLQSRGRARLLVGNDDV-----HIIARSDDE 2701

  Fly   320 LCG------SSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQ------------LADHVERIE 366
            |..      |:..:..|.......|.|:     |.:..|.|..:            :.:|:|.:.
Mouse  2702 LLDDFFHDQSTATSQAGTLSSIPTALTR-----WTEECKVLDAESMHDCVSVVKVPIVNHLEFLR 2761

  Fly   367 PGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVANR 431
            ..:||..:       ||.:          |..:|||.::|    .|.:|| ||..:.:..|...:
Mouse  2762 DEELEERR-------EKRR----------KQLAEEETKII----DKGKED-KENRDQSAQCTVTK 2804

  Fly   432 LRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSLSTASSKSAL----SFTD 492
            .....|        |.....|.:.:....:.||....:..|..:||:|..:..:.||    |..:
Mouse  2805 TNDSTE--------QNVSDGTPMPDSYPTTPSSTDAPTSESKETLGTLQPSQQQPALPPPPSLGE 2861

  Fly   493 IYIDPFAVDSPIDVVDLRRRSQRLFQQHQQQRLHPVHPVLQQQQSAEVTLSPRSSLSMETP---- 553
            |   |..:.||.:.|   ..|.:|....:.:.|.|..| ..:.::.::.|||..:::..:|
Mouse  2862 I---PQELQSPAEEV---ANSTQLLMPIELEELGPTRP-SGEAETTQMELSPAPTITSLSPERAE 2919

  Fly   554 ------------PASPMKYNAGAD--------QTPQA-LKEEPTYANALPA-------------- 583
                        ..|||..::.|.        .||.| ..|:||..::.|.
Mouse  2920 DSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTPAAGSSEQPTAGSSTPGDAPSVVAEVQGRPD 2984

  Fly   584 -------PPAYTAPP-----------PVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNL 630
                   ||..::||           .|.|||..:|.           :||..|...:......|
Mouse  2985 VSRESNQPPEDSSPPASSESSSTRDSAVAISGADSRG-----------ILEEPLPSTSSEEEDPL 3038

  Fly   631 AVAPLSPISEKPSLL-----DLPQEML---------SRSSSTSNTRSVSAAVSNESVAGDSGVFE 681
            |...| |....||.|     |:.:|:|         :||:.:||: |..|.|.|..|...|..|.
Mouse  3039 AGISL-PEGVDPSFLAALPDDIRREVLQNQLGIRPPTRSAPSSNS-SAPAVVGNPGVTEVSPEFL 3101

  Fly   682 AS-------------RAHLPRKELAQVQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQ--- 730
            |:             ||...|:||||                            .||:|...
Mouse  3102 AALPPAIQEEVLAQQRAEQQRRELAQ----------------------------NASSDTPMDPV 3138

  Fly   731 VYLRAALLPNSLTSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQ 795
            .:::.  ||:.|   |...|.|.:..|             |......:.......::|:.....|
Mouse  3139 TFIQT--LPSDL---RRSVLEDMEDSV-------------LAVMPPDIAAEAQALRREQEARQRQ 3185

  Fly   796 ISMAEFNPEDSTLKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTI 860
            :.........||.....:|.|   |:|.|....:........||........|.    ||..:..
Mouse  3186 LMHERLFGHSSTSALSAILRS---PAFTSRLSGNRGVQYTRLAVQRGGTFQMGG----SSSHNRP 3243

  Fly   861 TSSQTSTLTRNQAPCMELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSS 925
            :.|...||.|.:...: |..:..:.||.|..::||:.                         ::|
Mouse  3244 SGSNVDTLLRLRGRLL-LDHEALSCLLVLLFVDEPKL-------------------------NTS 3282

  Fly   926 MLHAYLQNM-----------------KQEFADKE---------TNTDRAYLPEKSRGQSQLMDDR 964
            .||..|:|:                 .|..::.|         |:.:|.....||...|. .::|
Mouse  3283 RLHRVLRNLCYHAQTRHWVIRSLLSILQRSSESELCIETPKLSTSEERGKKSSKSCASSS-HENR 3346

  Fly   965 PVKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHC----------GVAPHTFQRGAAERRSLRFHS 1019
            |:   ......|:.|.|:.:. |:.| .|:|:.|          |...|| ::.|:...::..|.
Mouse  3347 PL---DLLHKMESKSSNQLSW-LSVS-MDAALGCRTNIFQIQRSGGRKHT-EKHASSGSTVHIHP 3405

  Fly  1020 KAPKSVTKLHHTHIPRTSLDLELDLQAQHSKLY--FLNDQIAKLQNLKEVLQK----ACENKDPL 1078
            :|...|.:    |:        ||...|.:|::  ....|..|..|.:...::    ||......
Mouse  3406 QAAPVVCR----HV--------LDTLIQLAKVFPSHFTQQRTKETNCESDRERGSKQACSPCSSQ 3458

  Fly  1079 VAAWAIENEEFQRLVARADPAKCPE--ERQLQKLLMKTAKE----IHKLRKTKVPKG-CPDLVSF 1136
            .::..| ..:|..|:.:.|......  :..::.:.:.:..|    .|.|..:  |.| ..:::|.
Mouse  3459 SSSSGI-CTDFWDLLVKLDNMNVSRKGKNSVKSVPVSSGGEGETSPHSLEAS--PLGQLMNMLSH 3520

  Fly  1137 K--EKITFFTRKGLSVPELPSEFTLPEANPIEEEEEEEDENEFYNSAETAIAINTALVASSNRNK 1199
            .  .:.:..|.|.|.:..|.| ..||| |.:.|.:    .|...:.:.||...||:...::....
Mouse  3521 PVIRRSSLLTEKLLRLLSLIS-IALPE-NKVSEVQ----TNSSNSGSSTAATSNTSTTTTTTTTA 3579

  Fly  1200 NLSEHPHRATSGAVPKIPAPVVTPAATPAATPAAT---PAATSAATP-AATPVVSPAAQPDAK-P 1259
            .       |.:...|....||.:..|..|||..:|   .|:|:..|| .||..||.:....:| |
Mouse  3580 T-------APTPTPPAATTPVTSAPALVAATAISTITVAASTTVTTPTTATTTVSTSTTKGSKSP 3637

  Fly  1260 A 1260
            |
Mouse  3638 A 3638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	5/29 (17%)
		WW	103..132	CDD:278809	4/38 (11%)
		C2_Kibra	693..813	CDD:176062	17/122 (14%)
Huwe1	XP_006528996.1	DUF908	92..367	CDD:399185
		DUF913	431..892	CDD:399192
		UBA_HUWE1	1395..1434	CDD:270474
		WWE	1695..1756	CDD:397111
		fibronec_FbpA	<2809..>2992	CDD:411474	37/197 (19%)
		DUF4414	3044..3071	CDD:405126	7/26 (27%)
		DUF4414	3089..3120	CDD:405126	7/30 (23%)
		HECTc	4101..4454	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900