DRSC/TRiP Functional Genomics Resources

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Protein Alignment kibra and HACE1

DIOPT Version :9

Sequence 1:NP_001034055.1 Gene:kibra / 41783 FlyBaseID:FBgn0262127 Length:1288 Species:Drosophila melanogaster
Sequence 2:NP_065822.2 Gene:HACE1 / 57531 HGNCID:21033 Length:909 Species:Homo sapiens


Alignment Length:1055 Identity:207/1055 - (19%)
Similarity:355/1055 - (33%) Gaps:339/1055 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   124 AQSTQL-EDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASRSS 187
            |::.:| ||......|:...:::|...:..:.|.|.:  |||   ...:.:.:.:.|.:||:   
Human    18 ARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSK--FDV---NYAFGRVKRSLLHIAAN--- 74

  Fly   188 LCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSVGEKINARENGC 252
             |.|...:           ::|.::..:...|:::..|........|.....|...:.:|..|.|
Human    75 -CGSVECL-----------VLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNIC 127

  Fly   253 YDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQ 317
            .:        |.:..:|...|:|   |.||:..||        |.:|:.:.:.|.....:.||.|
Human   128 NN--------EGLTAIHWLAVNG---RTELLHDLV--------QHVSDVDVEDAMGQTALHVACQ 173

  Fly   318 -----TDLC-GSSGENLN----GGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIEPGQLES 372
                 |..| ..||.::|    .||       |...:|             ..|.:|        
Human   174 NGHKTTVQCLLDSGADINRPNVSGA-------TPLYFA-------------CSHGQR-------- 210

  Fly   373 DKDRILLIQEKEKLLNDLNSIS-----LKSRSEEEKRVIHQTRHKL---------EEDLKEAYEA 423
            |..:|||:: ..|.|.|.|.::     ::....|...|:.|...:|         .|||:|    
Human   211 DTAQILLLR-GAKYLPDKNGVTPLDLCVQGGYGETCEVLIQYHPRLFQTIIQMTQNEDLRE---- 270

  Fly   424 NNTCVANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSLST---ASSK 485
                  |.||      .:|:.|.:..:|     :.||..:|.:..:.::|..|.|||:   |..|
Human   271 ------NMLR------QVLEHLSQQSES-----QYLKILTSLAEVATTNGHKLLSLSSNYDAQMK 318

  Fly   486 SALSFTDIYIDPFAV--DSPIDVVDLRRRSQRLFQQHQQQRLHPVHPVLQQQQ------SAEVTL 542
            |.|....::...|.:  .||.:.:|:.....:   ..:.|...|:..:.....      :.|:..
Human   319 SLLRIVRMFCHVFRIGPSSPSNGIDMGYNGNK---TPRSQVFKPLELLWHSLDEWLVLIATELMK 380

  Fly   543 SPRSSLSMETPPASPMKYNAGADQTPQALKE-EPTYANALPAPPAY-------TAPPPVPISGVR 599
            :.|.|    |...|.:....|.||...::.. ||      |.|.:|       ....|..::|.:
Human   381 NKRDS----TEITSILLKQKGQDQDAASIPPFEP------PGPGSYENLSTGTRESKPDALAGRQ 435

  Fly   600 ARPYDLDSTV-LDCMMLEAKLQKLNMGTPLNLAVAPLSP----------------ISEKPS---- 643
            ....|....: :....|.|.:|...|.....:.....||                ::..|.    
Human   436 EASADCQDVISMTANRLSAVIQAFYMCCSCQMPPGMTSPRFIEFVCKHDEVLKCFVNRNPKIIFD 500

  Fly   644 ----LLDLPQEMLSR---------------------SSSTSNTRSVSAAVSNES----VAGDSGV 679
                ||:.| |::||                     .|...::..|...| ||:    |..|| :
Human   501 HFHFLLECP-ELMSRFMHIIKAQPFKDRCEWFYEHLHSGQPDSDMVHRPV-NENDILLVHRDS-I 562

  Fly   680 FEASRAHLPRKELAQVQ--IGLKYLKQEGV---------LVVSLERANNLLALWTASADNSQVYL 733
            |.:|...:.:...|:::  |.:::..:||:         .::|.|..|...||:|.|||.:    
Human   563 FRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQGVVREWFDILSNEIVNPDYALFTQSADGT---- 623

  Fly   734 RAALLPNSLTSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQIS- 797
              ...|||.:.:....|..|:       ||..| |...|.....|.:.......:.|:| :.:: 
Human   624 --TFQPNSNSYVNPDHLNYFR-------FAGQI-LGLALNHRQLVNIYFTRSFYKHILG-IPVNY 677

  Fly   798 --MAEFNPE-DSTLKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAP-NPG--------NN 850
              :|..:|| ...|:|  :|.:    ....|.:..|.:.......|....| .||        ||
Human   678 QDVASIDPEYAKNLQW--ILDN----DISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNN 736

  Fly   851 REESSDESTITSSQTSTLTRNQAPCMELQEQMAAELLGLGPLNEPECSDDDDDDEEE-------E 908
            :.|.  ...:|..:   :||      .:|.|:.|.|.|......|......|:.|.|       |
Human   737 KAEY--VQLVTELR---MTR------AIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPE 790

  Fly   909 LDDKQLVSDVGLMNSSSMLHAYLQNMKQ---------------EFADKETNTDRAYLPEKSRGQS 958
            :|    |||            :::|.:.               |..:..|..:|..|.:...|.|
Human   791 ID----VSD------------WIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSS 839

  Fly   959 Q--------LMDDRPVKRSQTFT--------------------------PSEAFSKNRYNCRLNR 989
            :        :|....:   |.||                          ||:...|:|...    
Human   840 RVPHGGFANIMGGSGL---QNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLV---- 897

  Fly   990 SDSDSAMHCGVAPHT 1004
                 |:|||...:|
Human   898 -----ALHCGSYGYT 907

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kibraNP_001034055.1 WW 57..87 CDD:238122
WW 103..132 CDD:278809 3/8 (38%)
C2_Kibra 693..813 CDD:176062 31/134 (23%)
HACE1NP_065822.2 Ank_2 <27..>283 CDD:330894 67/339 (20%)
ANK 1 64..93 6/43 (14%)
ANK repeat 66..95 CDD:293786 6/43 (14%)
ANK 92..217 CDD:238125 35/171 (20%)
ANK repeat 97..128 CDD:293786 5/30 (17%)
ANK 2 97..126 4/28 (14%)
ANK repeat 130..161 CDD:293786 11/41 (27%)
ANK 3 130..159 11/39 (28%)
ANK repeat 163..194 CDD:293786 8/30 (27%)
ANK 4 163..192 7/28 (25%)
ANK 5 196..226 12/58 (21%)
ANK repeat 196..221 CDD:293786 10/53 (19%)
ANK 6 228..257 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..433 8/40 (20%)
HECTc 554..903 CDD:238033 81/409 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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