Protein Alignment kibra and HECW2

DIOPT Version :10

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_006712709.1
• Gene: HECW2 / 57520
• HGNCID: 29853
• Length: 1579
• Species: Homo sapiens
• Alignment Length: 645
• Identity: 116/645 - (17%)
• Similarity: 209/645 - (32%)
• Gaps: 226/645 - (35%)

  Fly    33 HQQQQQQQHTHHQQQQQHHSD------------FPLPDGWDIAKDFDGKTYYIDHINKKTTWLDP 85
            |...:.::.|||.::.||:.|            ..||.||::..|..||.:::||.::.||::||
Human   959 HMITKVRRDTHHFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDP 1023

  Fly    86 RDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQ-----------------LEDPR 133
            |                ||:   :|..|.....:..||.:...                 |..|.
Human  1024 R----------------LPL---QSSRPTSALVHRQHLTRQRSHSAGEVGEDSRHAGPPVLPRPS 1069

  Fly   134 QEWKTVQEQMLSDYLSAA-QDQLE---NKREMFDVKQQR-------------------------- 168
            ..:.||......|.:..| .|::.   .:..:|::.|:|
Human  1070 STFNTVSRPQYQDMVPVAYNDKIVAFLRQPNIFEILQERQPDLTRNHSLREKIQFIRTEGTPGLV 1134

  Fly   169 ------------LLWAQEEYNHL-KLAASRSSLCSSSS----SMSRHDPELLRAD---------- 206
                        .|:.:|..::: ..|....|.|.|..    |..::.|...||:
Human  1135 RLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRD 1199

  Fly   207 -----------------------LMLARERVHQLKQELTHITNDISYTERGM--NTLY--SVGEK 244
                                   |.|...|.|.|:.....|   :.|:.:.:  |.||  .|||:
Human  1200 FEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQI---MGYSRKDLQRNKLYVTFVGEE 1261

  Fly   245 -------------INARE--NGCYDIAEVHA----------------IREEMLK----------V 268
                         :.:||  |..|.:.|..|                ...|..:          :
Human  1262 GLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALI 1326

  Fly   269 HKSLVSGEKVR---EELMRSLVQIKNELGRQQISEE---------NSDLASPFDRVCVASQTDLC 321
            |:.|:.....|   :.|:|.|..:.:   .:.:.||         ::|:....|.....:: ::.
Human  1327 HQYLLDAFFTRPFYKALLRILCDLSD---LEYLDEEFHQSLQWMKDNDIHDILDLTFTVNE-EVF 1387

  Fly   322 G--SSGENLNGGARFAEMAKTKWQYAE----WRKHIKKLQQQLADHVERIEPGQLESDKDRILLI 380
            |  :..|...|||......|.|.:|.|    ||     :::.:....|.:..|..|....|::.:
Human  1388 GQITERELKPGGANIPVTEKNKKEYIERMVKWR-----IERGVVQQTESLVRGFYEVVDARLVSV 1447

  Fly   381 ---QEKEKLLNDLNSISLKS-RSEEEKRVIHQTRHKLEEDLKEAYEANNTCVANRLRFHEEKQLL 441
               :|.|.::.....|.|.. |:..|.|..:...|.:......|.|          ||:.|::|.
Human  1448 FDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVE----------RFNNEQRLR 1502

  Fly   442 LDKLQEALKSTKLLEE---RLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDPF 498
            |  ||....::.:..|   .|:..:....|.:.....:    ||..::...|..:.:.|:
Human  1503 L--LQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKI----TALPRAHTCFNRLDLPPY 1556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	12/29 (41%)
		WW	103..132	CDD:459800	7/45 (16%)
		C2_Kibra	693..813	CDD:176062
HECW2	XP_006712709.1	HECW_N	45..162	CDD:465177
		C2_NEDL1-like	185..321	CDD:176073
		DMP1	<352..707	CDD:462128
		PHA03169	591..>801	CDD:223003
		WW	816..845	CDD:459800
		HECW1_helix	922..988	CDD:465766	7/28 (25%)
		WW	994..1023	CDD:459800	11/28 (39%)
		HECTc	1223..1577	CDD:238033	69/362 (19%)