Protein Alignment kibra and SMURF1

DIOPT Version :10

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_065162.1
• Gene: SMURF1 / 57154
• HGNCID: 16807
• Length: 757
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 124/615 - (20%)
• Similarity: 203/615 - (33%)
• Gaps: 204/615 - (33%)

  Fly     5 QQTASQSQHHLHPHHLRPQQQQQQHHHHHQQQQ----QQQHTHHQQQ------------------ 47
            |....|:|...:|......|..|...|.||..:    .:|.|..|.|
Human   203 QDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRI 267

  Fly    48 --------------------QQHHSD------------FPLPDGWDIAKDFDGKTYYIDHINKKT 80
                                |.|.|:            .|||.||::.....|:.|::||.|:.|
Human   268 PSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTT 332

  Fly    81 TWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLA-QSTQLEDPRQEWKTVQEQML 144
            .:.|||                                 ::|:. ...||::|.|......|..|
Human   333 QFTDPR---------------------------------LHHIMNHQCQLKEPSQPLPLPSEGSL 364

  Fly   145 SDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASRSSLCSSS-SSMSRHDPELLRADLM 208
            .|....||....:..:...|.:..|...|.:..|.::..||..:...| ..:.:..|:.|:..||
Human   365 EDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLM 429

  Fly   209 -------------LARERVHQLKQELTH-----------------ITNDISYTERGMNTLYSVGE 243
                         :|||.::.|..|:.:                 |..|.|.....::..:.||.
Human   430 VKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGR 494

  Fly   244 KINARE------NGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQI-KNE----LGRQQ 297
            .:....      ||.:.:    ...:::|.....|...|.|..||.:|||.| :|:    |....
Human   495 IMGLAVFHGHYINGGFTV----PFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTF 555

  Fly   298 ISEENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKW--QYAEWRKHIKKLQQQ--- 357
            ..|.|:     |.|:.   |.:| ..:|.|:    ...|..|.::  .|..|| .::.::.|
Human   556 CVEHNA-----FGRIL---QHEL-KPNGRNV----PVTEENKKEYVRLYVNWR-FMRGIEAQFLA 606

  Fly   358 LADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISL---KSRSEEEKRVIHQTRHKLEEDLKE 419
            |......:.|..|....|:    :|.|.::..|:.|.|   ||.:    |:.|
Human   607 LQKGFNELIPQHLLKPFDQ----KELELIIGGLDKIDLNDWKSNT----RLKH------------ 651

  Fly   420 AYEANNTCVA--NRLR--------FHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGS 474
                   |||  |.:|        |.||::..|  ||....||::   .|:.|.:....:.::|.
Human   652 -------CVADSNIVRWFWQAVETFDEERRARL--LQFVTGSTRV---PLQGFKALQGSTGAAGP 704

  Fly   475 SLGSLSTASS------KSALSFTDIYIDPF 498
            .|.::....:      |:...|..|.|.|:
Human   705 RLFTIHLIDANTDNLPKAHTCFNRIDIPPY 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	11/29 (38%)
		WW	103..132	CDD:459800	3/29 (10%)
		C2_Kibra	693..813	CDD:176062
SMURF1	NP_065162.1	C2_Smurf-like	14..138	CDD:176028
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	193..237		9/33 (27%)
		WW	236..267	CDD:197736	4/30 (13%)
		WW	307..339	CDD:197736	14/64 (22%)
		HECTc	399..754	CDD:238033	80/386 (21%)