DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and plekha7a

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001129715.1	Gene:	plekha7a / 571486	ZFINID:	ZDB-GENE-050419-75	Length:	1197	Species:	Danio rerio

Alignment Length:	1388	Identity:	252/1388 - (18%)
Similarity:	432/1388 - (31%)	Gaps:	490/1388 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYI 120
            |||........||:.::||...:.||||.||.  .:|......:..:||.||||.:......::|
Zfish    10 LPDNGSYGVCRDGRVFFIDDEARATTWLHPRT--GQPVNSGHMIRSDLPSGWEEGFTKEGASFFI 72

  Fly   121 NHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQ---RLLWAQEEYNHLKLA 182
            :|                  .|..:.::.....|:..:...|.::.|   |:|
Zfish    73 DH------------------NQRTTTFIHPVTGQISTENSDFRLQDQPGGRML------------ 107

  Fly   183 ASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSVGEKINA 247
            ...||..|.:|:                           |..|:.:..|.         |.| .:
Zfish   108 KQPSSTISEAST---------------------------TVTTSTVDSTS---------GSK-GS 135

  Fly   248 RENGCYDIAEVHAI--REEMLKVHKS---LVSGEKVREEL--MR------------SLVQIKNEL 293
            |.:|     .||:.  |:..:|.:.|   :|.|...:::.  ||            .|...|:
Zfish   136 RSSG-----RVHSFGKRDHAIKRNPSXPVVVRGWLYKQDSSGMRLWKRKWFVLADFCLFYYKD-- 193

  Fly   294 GRQQISEENSDLAS------------PFDRVC-----VASQTDL-----CGSSGENLNGGARFAE 336
                 |.|.|.|.|            |.|.:.     .|..|.:     ...:.|::||..|...
Zfish   194 -----SREESVLGSIPLPSYTIAPVGPEDHISRKYAFKAEHTGMRTYYFSADTQEDMNGWVRAMN 253

  Fly   337 MAKTKWQYAEWRKH-IKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSE 400
            .|      |..:.| :|:.:....|||.                :.||.|
Zfish   254 QA------ALMQTHTVKRDECGHPDHVN----------------VSEKLK--------------- 281

  Fly   401 EEKRVIHQTRH---------------KLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEA-- 448
              |:.:.||.|               .|.||.:|.:..           ..|.|:...::::|
Zfish   282 --KQAVPQTNHINSYVIPKPEVIQSDGLPEDKREGFVG-----------EVEIQVTPREMEQARG 333

  Fly   449 -LKSTKLLEERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDPFAVD---SPID---V 506
             ..:::::|..:.:..|.....::|.:...::||               |..|.   :||:   :
Zfish   334 KSPASRVVEVEVLAPGSTPPSRVASRAPSRAVST---------------PPVVQRNGTPIEQNGM 383

  Fly   507 VDLRR----RSQRLFQQHQQQRLHPVHP-VLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQ 566
            ...:|    .:|...|..::..|..|.. |..|::.....:|..|::...|||..| ||  |...
Zfish   384 PGCQRGATPSAQTPVQVQRRSTLEQVENWVKVQKEERHGLVSTESTVPRRTPPIHP-KY--GTMD 445

  Fly   567 TPQALKEEPTYANALPAPPAYTAPPPV-----------PISGVRARPYDLDSTVLDCMMLEAKLQ 620
            ..|:|   |..:...|..|.:..|...           .|.|...||...|:||......:.: |
Zfish   446 KYQSL---PKTSRQSPPAPHHQLPSEYKYSHDRLNHFQKIHGHTKRPTTHDNTVWQLFEWQQR-Q 506

  Fly   621 KLNMGTPLNLAVAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGD--------S 677
            :...|:|......|....|             :..|||.|...||.:||......|        :
Zfish   507 QFRHGSPFAPVYTPAPDYS-------------TAVSSTRNNPDVSRSVSVPPTLADIPPPGPPGA 558

  Fly   678 GVFEASRAHLPRKELAQVQIGLKYLKQEGVLVV---------------SLERAN----------- 716
            .:....|.|.|.:     ::.::.|:...::.|               ::||.:
Zfish   559 RLMSPRRPHTPAE-----RVTVRPLEDRPIVEVPPSNSPHRLRSYKSATIERRSMPPSAYITHTV 618

  Fly   717 NLLALWTASADNSQVYLRAALLPNSLTSIRTKAL-GDFQKPVFNDTFAVPITLDKLL--TKSLQV 778
            :..:|...:||::.::|:..|....|....|:|| |...|||......|.:||.:|.  .|.||.
Zfish   619 SAPSLRGKTADDTYMHLKKGLEYLDLKVSGTEALKGRPAKPVKVAESDVDVTLSRLCEQDKILQE 683

  Fly   779 TVVTMTGQK------EEIIGTVQISMAEFNPE----DSTLKWYNVLSSKFI-------------- 819
            ....::|.|      |.::......|.::..:    |.......:|....:
Zfish   684 LEFRLSGLKDDKDKLESVLDVSHQQMEQYKDQPSHTDKIAYQQRLLQEDLVHIRADISRVSTEME 748

  Fly   820 ----------PSFESL-DIPST----------------------------SAAAAAAAVAASNAP 845
                      .|.|.| |:..|                            |:......:...:..
Zfish   749 RAWDDYSGMEQSVEQLRDVLQTQMTLCTSPQEKNQLKRELWRMEDVMTGLSSTKETFKITVDSVK 813

  Fly   846 NPGNNREESSDESTITSSQTSTLTRNQAPCMELQEQMAAELLGLGPLNE--------PECSDDD- 901
            ||......|..|||:.|   ..:|.:.|.....|..:.:..|.|...||        |...:||
Zfish   814 NPERKLVPSVIESTVPS---RCMTPSAAEVRSPQRSLTSSPLSLPLDNEDLRNRHPVPNWEEDDA 875

  Fly   902 ----------DDDEEEELDDKQLVSDVGLMNSSSML-HAYLQNMKQEFADKETNTDRAYLPEKSR 955
                      |:|....:..        |...:|:: |..::.:|::..:::.:.:.:|    |.
Zfish   876 PPRPPLPLLYDEDTPPVVPP--------LPKETSVIRHTSVRGLKRQSDERKRDRESSY----SN 928

  Fly   956 GQSQLMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHTFQRGAAERRSLRFHSK 1020
            |     |.|...||....|....|            :..|.|......|.||......|.|.:..
Zfish   929 G-----DYRLELRSYLSEPELPVS------------AHGADHVDPGYLTLQRRGLSGSSSRINQY 976

  Fly  1021 APKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKAC-------ENKDPL 1078
            ..             .|..|..||            :::.::..|..|::.|       :...|.
Zfish   977 GV-------------ASCSLRRDL------------ELSTMERPKSALERLCSGEPQLEQQSQPQ 1016

  Fly  1079 VAAWAIENEEFQRLVARADPAKCPEERQLQKLLMKTAK------EIHKLRKTKVP---------- 1127
            ....::| |:.:|:            ::.|:.|::..|      |.|..|.:..|
Zfish  1017 RVRMSVE-EQLERM------------KRHQRALVRERKRNLSQGERHHSRASTRPVNSDPGSALF 1068

  Fly  1128 --------------KGCPDLVSFKEKITF---FTRKGLSVPELPSEFTLPEANPIEEEEEEEDEN 1175
                          :..|.:.|..|.:.|   .||: ||.|:   :..:|:....:|.:|:....
Zfish  1069 VEPHRPASDEWLTVRARPVMESELEPLDFEFDITRE-LSTPQ---KVWIPQRLIDDESDEDPSPE 1129

  Fly  1176 EFYNSAETAIAINTALVASSNRN 1198
            |....:.|...|.|.|..||.|:
Zfish  1130 EKETRSRTVAKIKTLLSKSSMRS 1152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	11/29 (38%)
		WW	103..132	CDD:278809	8/28 (29%)
		C2_Kibra	693..813	CDD:176062	29/158 (18%)
plekha7a	NP_001129715.1	WW	55..84	CDD:278809	9/46 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..148		16/103 (16%)
		PH_PEPP1_2_3	153..256	CDD:270068	21/115 (18%)
		PH	159..255	CDD:278594	19/102 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..384		8/50 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..467		14/49 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..577		16/86 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..928		18/112 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1032..1064		7/31 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900