Protein Alignment kibra and wwc3

DIOPT Version :9

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001103940.1
• Gene: wwc3 / 566492
• ZFINID: ZDB-GENE-070209-229
• Length: 1148
• Species: Danio rerio
• Alignment Length: 1250
• Identity: 368/1250 - (29%)
• Similarity: 591/1250 - (47%)
• Gaps: 251/1250 - (20%)

  Fly    47 QQQHHSDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESY 111
            :::..|:.|||.||:.|:|:||:.:||||..::|:|:||||..|||.||.||||||||:|||..|
Zfish     8 KRRESSELPLPPGWEEARDYDGRVFYIDHNTRQTSWIDPRDRITKPLTFADCVGDELPLGWEVVY 72

  Fly   112 DPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEE- 175
            |..:|.|||:|:.::||:|:||.:|:..||:||.:||..||:.|..|:||:.:|||||..||:|
Zfish    73 DQQVGVYYIDHINKTTQIENPRTQWRQEQERMLKEYLVVAQEALNAKKEMYQIKQQRLELAQQEM 137

  Fly   176 --YNHLKLAASRS--SLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMN 236
              :|.|....:||  |..|.|||.:::||:.::|::...|||:.:|||||..:..::.|.|.|:.
Zfish   138 QLFNQLTQDDNRSITSSHSGSSSNAKYDPDQIKAEIACRRERLSRLKQELAQMRQELQYKEMGVE 202

  Fly   237 TLYSVGEKINARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIK-------NELG 294
            ||..:..|:::.:.. |.:.|..||..|:..:.|::.:|||.|::|::||.::.       ||:.
Zfish   203 TLQEIDRKMSSSQTN-YKLDEAQAIFSELRSIKKAISTGEKERQDLIQSLAKLTLNFCDSINEVT 266

  Fly   295 RQQISEENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLA 359
            ..  :|..:|..|.........||||.|..|.  ...:..|:..|..|||.|.:|.:..:|.|||
Zfish   267 NN--AESLADSCSVQQYTDAGCQTDLMGEFGS--QESSLLADRVKLSWQYEEAKKKMSSIQHQLA 327

  Fly   360 DHVERIEPGQLESDK--DRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYE 422
            ........|:.|:|:  |.:.|::|||.||.:|..:|.:..|.:....:.:.:.:|:::::.|:.
Zfish   328 QLDSESWSGRAEADRDWDCLQLLREKETLLQELTLLSQQQHSSDTLLQLQEEKRRLQDEVQRAHS 392

  Fly   423 ANNTCVANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSL-----STA 482
            |.:.....|:...|::.:|:.:|:||.:.|..|..:|||.|: |..::||.||.|||     |.|
Zfish   393 AQSQGANQRILLQEKRNVLMRQLEEATRITTYLHSQLKSLSA-SNLTVSSSSSRGSLASSRGSLA 456

  Fly   483 SSK---SALSFTDIYIDP--FAVDSPIDVVDLRRRSQRLFQQHQQ------QRLHPVHPVLQQQQ 536
            ||:   |::||||||..|  ...:...||:|...|.....:.|..      :|.|.....|
Zfish   457 SSRGSLSSVSFTDIYGLPQYDRTEGSSDVLDPSFRYLLPLESHSSGSAYGPKRSHDTPQSL---- 517

  Fly   537 SAEVTLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALPAPPAYTAPPPVPIS----- 596
               .:||.|||||..:||:|||.                        .|.::||...|::
Zfish   518 ---TSLSSRSSLSSLSPPSSPMD------------------------TPYHSAPQDCPLAQMTEE 555

  Fly   597 ------------GVRARPYDLDSTVLD----------CMMLEAK------LQKLNMGTPLNLAVA 633
                        |:|.:......|.|.          ..:||.|      ||..:..|.:.|
Zfish   556 YMEVASRGLLAEGLRTQSQAQQHTTLSGDGEVGIAATAHLLEGKSHRDAALQGTHSSTGVTL--- 617

  Fly   634 PLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEA-SRAHLPRKE---LAQ 694
                            ...|.|.::...|.|||.|:.:.:|.||||||| ||:.....|   .||
Zfish   618 ----------------RCKSASRTSRRARRVSAGVNEDVLATDSGVFEAWSRSRTEESEEVSFAQ 666

  Fly   695 -----------VQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSLTSIRTK 748
                       :||||.|......|::.:.:..||..  .:..|..:|:::..:||...:...|.
Zfish   667 DVTVAVSEPVHIQIGLLYDSNSRFLLLHVLQMRNLSK--ASIRDRWKVFVKVHVLPMDSSRPCTY 729

  Fly   749 ALGDFQKP----VFNDTFAVPITLDKLLTKSLQVTVVTMTG-QKEEIIGTVQISMAE-FNPEDST 807
            .....|:|    .||::|.:|:::......:||.::.|:.. .:||::|:.|:|:.: ....:..
Zfish   730 YCCKAQEPQSLLSFNESFRIPLSVGGPGAHALQFSLSTLGPLAQEELLGSAQVSLTDCVGSTEML 794

  Fly   808 LKWYNV---LSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDE--STITSSQTST 867
            .:|..|   .:....|....|                 :.||...:.||..:|  ..:..|..|.
Zfish   795 FQWLKVQFHSTENHRPEHRRL-----------------SQPNRIMDEEEEKNEGQGKLEVSVVSH 842

  Fly   868 LTRNQAPCMELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDK----QLVS---------DVG 919
            |           |:|..||                ...||||:.|    :.||         |.|
Zfish   843 L-----------EEMKKEL----------------QRSEEELERKEEPGEAVSERSWQAESVDSG 880

  Fly   920 LMNSSSMLHAYLQNMKQE--------------------FADKETNTDRAYL------PEKSRGQ- 957
            ..||::.:....:::..|                    ..||.|||:..:.      |::..|:
Zfish   881 CSNSTAFVIPCPESLCGEGICLTSGRRCLQPAERNPIIKVDKATNTEGVFAEPMRMRPKERTGRW 945

  Fly   958 ---SQLMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHTFQRGAAERRSLRFHS 1019
               |..|....:.|||||:|.   ::::|.|||.||||||:.....:|  |.|...|||:||:..
Zfish   946 GHSSPFMRSSTIVRSQTFSPG---ARSQYVCRLYRSDSDSSTLPKKSP--FIRNTLERRTLRYKQ 1005

  Fly  1020 KAPKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACEN-KDPL-VAAW 1082
            ::.:|......|   ||||||||||||..::...|.:::|.|:.||..|::..:. :.|. :..|
Zfish  1006 QSHRSSLAEQPT---RTSLDLELDLQACRTRQRQLTEELAALRELKLRLEEPMQGPRGPADLPHW 1067

  Fly  1083 AIENEEFQRLV---ARADPAKCPEERQ---LQKLLMKTAKEIHKLRKTKVPKGCPDLVSFKEKIT 1141
            |:.:|.|:.|:   .|.......|:||   .::.|.|.:||:.::|.....:..| :.:||||:.
Zfish  1068 ALRDERFRNLLREAQRQSKQTRQEQRQEEAAERRLRKASKEVLQMRGQSHKEPLP-VQTFKEKMA 1131

  Fly  1142 FFTRKGLSVPELPSE 1156
            ||||...::|.||::
Zfish  1132 FFTRPRFNIPPLPAD 1146

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	15/29 (52%)
		WW	103..132	CDD:278809	15/28 (54%)
		C2_Kibra	693..813	CDD:176062	30/136 (22%)
wwc3	NP_001103940.1	WW	17..46	CDD:278809	14/28 (50%)
		WW	64..93	CDD:278809	15/28 (54%)
		C2_Kibra	677..800	CDD:176062	28/124 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592606
Domainoid	1	1.000	249	1.000	Domainoid score	I2092
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	520	1.000	Inparanoid score	I1228
OMA	1	1.010	-	-		QHG50236
OrthoDB	1	1.010	-	-		D181722at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26551
orthoMCL	1	0.900	-	-		OOG6_103792
Panther	1	1.100	-	-	O	PTHR14791
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.770