DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and trip12

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_005159283.1	Gene:	trip12 / 564866	ZFINID:	ZDB-GENE-041111-262	Length:	2096	Species:	Danio rerio

Alignment Length:	1291	Identity:	249/1291 - (19%)
Similarity:	396/1291 - (30%)	Gaps:	452/1291 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 PYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKR------EMFDVKQQRLLWAQEE 175
            |.::..| |..|..|..::..|..| |||...|.|..|.....      |.|.:..||
Zfish   606 PVFLEKL-QVIQFIDVAEQALTALE-MLSRRHSKAILQAGGLADCLLYLEFFSINAQR------- 661

  Fly   176 YNHLKLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYS 240
             |.|.:||   :.|.|.:....|          ...:.:..|.|.|||  .|....|........
Zfish   662 -NALAIAA---NCCQSITPDEFH----------FVADSLPLLTQRLTH--QDKKSVESTCLCFAR 710

  Fly   241 VGEKINARENGCYDIAEVHAIREEMLKVHKSLV-------SGEKVREELMRSLV-----QIKNEL 293
            :.:.....||....:|.    |:.:..:.:.||       ||..:....|.||:     .:..:|
Zfish   711 LVDNFQHEENLLQQVAS----RDLLTNIQQLLVLTPPVLSSGMFIMVVRMFSLMCSNCPCLAVQL 771

  Fly   294 GRQQISEENSDLASPFDRVCVAS------QTDLCGSSGENL------------------------ 328
            .:|.|:|....|      :|.||      |.||...|.:.|
Zfish   772 MKQNIAETLRFL------LCGASNGSCQEQIDLVPRSPQELYELTSLICELMPCLPREGIFAVDA 830

  Fly   329 ---NGGARFAEMAKTKWQYAE----WRKH-------IKKLQQQLADHVERIEPG----------- 368
               .|.|:..|.|  .||:.:    |..:       |:...|...|.:.....|
Zfish   831 MLKKGSAQTTEGA--IWQWRDDRGLWHPYNRIDSRIIETAHQNGEDEISLSTLGRVYTIDFNSMQ 893

  Fly   369 QLESDKDRILLIQEK-EKLLNDLNSISLKSRSEEEKRVIHQTRHKLEED--------------LK 418
            |:..|......||.| ..|.|......|:.|.|:.:..:      ::||              |.
Zfish   894 QINEDTGTARAIQRKPNPLANPNTGGHLEVRREDARAQL------MKEDPELAKCFIKTLFGVLY 952

  Fly   419 EAYEAN------NTCVANRLR--FHEEKQLLLDKLQE---------------------ALKSTKL 454
            |.|.::      :.|:...||  :..:.:||.|.|:.                     :|:..::
Zfish   953 EVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLRNHAVSSHIASMLSSQDLKIVVGSLQMAEI 1017

  Fly   455 LEERL-----------------KSFSSESTF------SISSGSS---LGSLSTASSKSALSFTDI 493
            |.::|                 |:.:....|      :.:||::   ..:::||::.:|.:.|..
Zfish  1018 LMQKLPDVFSVYFRREGVMHQVKNLAESEVFLTSPPKACTSGTASLCTTTITTATTTAASNVTPD 1082

  Fly   494 YIDPFAVDSPIDVVDLRRRSQRLFQQHQQQRL---HPVHP----------VLQQQQSAEVTLSPR 545
            ...|....|..|.:||..:. ||....:::||   .|..|          |..|.:|...|.||:
Zfish  1083 LGSPSFQHSMDDSLDLSPQG-RLSDVLKRKRLPKRGPRRPKYSPPRDDDKVDNQAKSPTTTQSPK 1146

  Fly   546 SSLSMETPPASPMKYNAGADQTPQALKEEPTYANALPAPPAYTAPPPVPISGV-RARPYDLDSTV 609
            ||..              |...|:...:..|.||:..:.|:.||    .:||: |..|.|..|..
Zfish  1147 SSFL--------------ASLNPKTWGKLGTQANSANSEPSRTA----GVSGLARVPPKDSVSNN 1193

  Fly   610 LDCMMLEAKLQKLNMGTPLNLAVAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVA 674
            .|.:....|.|.                                       ::.|....::|||.
Zfish  1194 RDKIKAWIKEQA---------------------------------------SKFVERYFNSESVD 1219

  Fly   675 GDSGVFEASRAHLPRKELAQVQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLP 739
            |.:.....    |.|...|..|:.|:  ...|  |..||..:::::....|:...|   .:.|:.
Zfish  1220 GSNPALNV----LQRLCTATEQLNLQ--MDSG--VECLEEISSIVSESDVSSFEIQ---HSGLVK 1273

  Fly   740 NSLTSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTV-VTMTGQKEEIIGTVQISMAEFNP 803
            ..|..:.:.:..|            .|:.|:.:.:.|.|.. ..:.||:..         ...:|
Zfish  1274 QLLLYLTSNSERD------------TISRDERIKRFLHVFFGCPIPGQEPP---------GRLDP 1317

  Fly   804 -EDSTL-----KWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITS 862
             |:..|     |..|.||.......:..|.||.:                ||....|.......:
Zfish  1318 TENGPLLALVHKMNNCLSQMEQFPVKVHDFPSGN----------------GNGSRGSQALKFFNT 1366

  Fly   863 SQTSTLTRNQAPCMELQE-------------QMAAE----LLGLGPLNEPECSDDDDDDEEEELD 910
            .|.....:....|..:::             ..|.|    :.|.|.:.| |..|.|||..::|:|
Zfish  1367 HQLKCQLQRHPDCTNVKQWKGGPVKIDPLALVQAIERYLVVRGYGRIRE-EDEDSDDDGSDDEID 1430

  Fly   911 DKQLVSDVGLMNSSSMLH-------------------AYLQNMKQEFADKETNTDRA-------- 948
            :.....   .:||.|:.|                   |..|...|...::|:..|.|
Zfish  1431 ESLAAQ---FLNSGSVRHRLQFYIGEHLLPYNMTVYQAVRQFSLQAEEERESTDDEANPLGRAGI 1492

  Fly   949 --------YLPEK------------SRGQSQLMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSD 993
                    |.|.:            .||::|   ..|.|.|..                |....|
Zfish  1493 WTKTHTVWYKPVREDEEGCKDAVGGKRGRAQ---TAPTKTSPR----------------NAKKQD 1538

  Fly   994 SAMHCGVAPHTFQRGAAERRSLRFHSKAPKSVTKLHHTHIPRTSLDLELDLQAQHS---KLYFLN 1055
            ...|.||.|     ..|...........|:.:|      ....|:::.|.|:..||   ..::|.
Zfish  1539 ELWHEGVCP-----SVANPLETYLICDPPEGIT------FDDPSMEVILLLRVLHSISRYWFYLY 1592

  Fly  1056 DQIAKLQNLKEVLQKACENKDPLVAAWAIENEEF--QRLVARADPAKCPEERQLQKLLMKTAKEI 1118
            |..|    .||:                |...||  .:|.|:|:       ||||..|:.....|
Zfish  1593 DNAA----CKEI----------------IPTGEFINSKLTAKAN-------RQLQDPLVIMTGNI 1630

  Fly  1119 HKLRKTKVPKGCPDLVSFKEK-----ITFFTRKGLSVPELPSEFTLPEANPIEEEE 1169
             ....|::.|.||....|..:     :|.|.|.......|.   |.||.|..:.::
Zfish  1631 -PTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLD---TNPEINQSDSQD 1682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809	4/14 (29%)
		C2_Kibra	693..813	CDD:176062	22/126 (17%)
trip12	XP_005159283.1	WWE	842..907	CDD:280915	11/66 (17%)
		HECTc	1693..2094	CDD:238033
		HECTc	1711..2090	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900