Protein Alignment kibra and magi2a

DIOPT Version :10

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001314782.1
• Gene: magi2a / 564112
• ZFINID: ZDB-GENE-050810-4
• Length: 1503
• Species: Danio rerio
• Alignment Length: 1015
• Identity: 213/1015 - (20%)
• Similarity: 361/1015 - (35%)
• Gaps: 273/1015 - (26%)

  Fly    55 PLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYY 119
            ||||.|::|....|:.|:|||..|.|:||||| ...|.:..|:|..:|||.|||:..||..|.||
Zfish   305 PLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPR-LAKKAKPPEECKENELPYGWEKIDDPIYGTYY 368

  Fly   120 INHLAQSTQLEDPRQEWK---TVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQE----EYN 177
            ::|:.:.||.|:|..|.|   ..|:||.|..||:.        .:..|.:::.|:.::    :.:
Zfish   369 VDHINRRTQFENPVLEAKRRLQHQQQMQSQGLSSL--------PLPAVYREKPLFTRDPTQLKGS 425

  Fly   178 HLKLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSVG 242
            .|.....:|::....:.:...:|:                  |...:.:.|.......:...:.|
Zfish   426 FLSTPLQKSNMGFGFTIIGGDEPD------------------EFLQVKSVIPDGPAAQDGKMATG 472

  Fly   243 EKINARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDLAS 307
            :.|....:.|. :...||   :::|:.:|:..|:.|      :||..:.........:..:.|.|
Zfish   473 DVIVYINDVCV-LGTTHA---DVVKLFQSVPIGQSV------TLVLCRGYPLPYDPEDAANTLLS 527

  Fly   308 P---FDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIEPGQ 369
            |   .||..:.:..:...|..|.::..|||.:..:|           ..:|....|  ..::.|.
Zfish   528 PLGLIDRPLLVNGRNSYDSYMEYISRTARFVDPLQT-----------TMVQPHPGD--THLDAGP 579

  Fly   370 LESDKDRILLIQEKEKLLNDLNSISLKSRSEE--EKRVIHQTR---------------HKLEEDL 417
            ||                   :|:|:.|....  |...|:..:               .::::.|
Zfish   580 LE-------------------DSVSMASSGAAGGELLTINMVKGADGFGFTIADSNGGQRVKQIL 625

  Fly   418 KEAYEANNTCVANRL-RFHEEKQLLLDKLQ--EALKSTKLLEERLKSFSSESTFSISSGSS---- 475
             ||......|..:.: ..:::..|.|...|  |.||...:        .:|:|..|..|.:
Zfish   626 -EAQGCPGLCEGDLIVEINQQPALTLSHTQVVELLKECPI--------GTEATLVIQRGGTGHFS 681

  Fly   476 --------------LGSLSTASSKSALSFTDIYI-----DPFAVDSPIDVVDLRRRSQRLFQQHQ 521
                          |.|.:|:.|..||..:..|:     ..|.:..| |..||..:|:.:::..|
Zfish   682 PWKTTKQVLEHWDPLSSPTTSLSVHALPHSAPYLHWPSGPEFDLAKP-DPYDLYEKSRAIYENRQ 745

  Fly   522 ---QQRLHPVHPVLQQQQSAEVTLSPRSS------LSMETP--PASPM---KYNAGADQTPQALK 572
               .:...|..|..:.|: .||.|..:.|      |..|.|  |.||.   |...||     .::
Zfish   746 PGLPRASLPADPSAEFQE-VEVHLRRQKSGFGFRILGGEEPGQPVSPKAQEKILIGA-----IIE 804

  Fly   573 EEPTYANALPAPPAYTAPPPVPISG--VRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAVAPL 635
            :.|...:....|    ....:.:.|  |..:|:   ..|:|.|...|:..::.:  .:...|.|.
Zfish   805 KSPADKDGRLRP----GDELISVDGIVVAGKPH---RYVIDLMHGAARTGQVKL--TVRRRVQPT 860

  Fly   636 -SPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRKELAQVQIGL 699
             .|..|........|....||...|.....::|.|..|....:|......|.....:...|.|..
Zfish   861 GEPFPENGRSPGSTQHSSPRSDFNSRMFCNNSAPSQNSAPSTTGSSPPDTAANQNAQPNDVSIQR 925

  Fly   700 KYLKQEG---VLVVSLERANNLLALWTASADNSQVYLRAALLPNSLTSI----------RTKALG 751
            |  :.||   |::.||.|..      ||:         ||.:|:.:..|          :.| :|
Zfish   926 K--ETEGFGFVIISSLNRPE------TAA---------AAAVPHKIGRIIEGSPADHCGKLK-VG 972

  Fly   752 DFQKPVFNDTFA-------VPITLDKLLTKSLQVTVVTMT------GQKEEIIGTVQISMAEFNP 803
            |....|.|.:..       |.:..|..|:.:|::.....|      |..|:     |..||:.:|
Zfish   973 DRILAVNNQSIVNMPHADIVKLIKDAGLSVTLRIIPQEETNSTPSAGSSEK-----QSPMAQPSP 1032

  Fly   804 EDSTLKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASN-----APNPGNNREESSDESTITSS 863
                                 :..|:|.....||.:|.||     ||.|      |..:..|:.:
Zfish  1033 ---------------------VCQPNTVNQTGAAPLANSNAQQNSAPQP------SPIKQPISEA 1070

  Fly   864 QTSTLTRNQA---PCMELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSS 925
            |.|.:|:|..   |....|:         .|..:|..:...|.....|:..:|.|.
Zfish  1071 QPSLVTQNSPANHPSSVTQQ---------NPQTQPVQTYSHDSSYRSEVKARQDVK--------- 1117

  Fly   926 MLHAYLQNMKQEFAD-KETNTDRAYLPEKSRGQSQLMDDR 964
                  .:::|.|.| ::...|..:.|.....|...:|.|
Zfish  1118 ------PDIRQPFTDYRQPPVDYRHPPVADYRQPPTLDYR 1151

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	15/29 (52%)
		WW	103..132	CDD:459800	14/28 (50%)
		C2_Kibra	693..813	CDD:176062	31/145 (21%)
magi2a	NP_001314782.1	PDZ0_MAGI-1_3-like	24..103	CDD:467212
		NK	122..286	CDD:450170
		WW	307..337	CDD:238122	16/30 (53%)
		WW	352..383	CDD:197736	15/30 (50%)
		PDZ1_MAGI-1_3-like	426..510	CDD:467213	16/111 (14%)
		PDZ2_MAGI-1_3-like	594..675	CDD:467214	15/89 (17%)
		PDZ3_MAGI-1_3-like	763..855	CDD:467215	22/106 (21%)
		PHA03247	<855..1180	CDD:223021	76/371 (20%)
		PDZ4_MAGI-1_3-like	918..1008	CDD:467216	24/107 (22%)
		PDZ5_MAGI-1_3-like	1181..1263	CDD:467217
		PHA03307	1209..>1434	CDD:223039