DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and hecw1b

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_021336549.1	Gene:	hecw1b / 563730	ZFINID:	ZDB-GENE-060503-2	Length:	1555	Species:	Danio rerio

Alignment Length:	881	Identity:	169/881 - (19%)
Similarity:	274/881 - (31%)	Gaps:	301/881 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 HH---SDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESY 111
            ||   .|.|||..|:...|..|:.:|:||||:.|||..|....|             |.|...|
Zfish   763 HHYPTIDEPLPPNWEARIDSHGRVFYVDHINRTTTWQRPTSAAT-------------PDGLRRS- 813

  Fly   112 DPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEY 176
                        ....|:|...:.::|:|..|.::..........|.|.........|     :.
Zfish   814 ------------GSVQQMEQLNRRYQTIQRTMATERREEESGSPRNDRTANTETDSPL-----QT 861

  Fly   177 NHLKLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSV 241
            |.|:    |.:.||.....        :..|:|....|       ..||:...:|....|
Zfish   862 NELR----RDTSCSPGHCQ--------KITLLLQSPAV-------KFITHPEFFTVLHAN----- 902

  Fly   242 GEKINARENGCYDI-AEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDL 305
                    .|.|.: .....::..:||:.:...:.|:.:..  |.||...|.....|:     :|
Zfish   903 --------YGAYRMFTNSSCLKHMVLKIRRDARNFERYQHN--RDLVTFLNRFADAQL-----EL 952

  Fly   306 ASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVER----IE 366
            ...::     .:||..|.|                                ...||..|    |:
Zfish   953 PRGWE-----IKTDPQGKS--------------------------------FFVDHNSRATTFID 980

  Fly   367 PGQLESDKDRILLIQEKEKLLNDLNSIS----LKSRSEEEKRVIHQTR--HKLEEDLKEAYEANN 425
            |        ||.|  :..:|.|.|....    |:|.|..|...:.:||  ..|      |...|:
Zfish   981 P--------RIPL--QNGRLPNHLTHRQHLQRLRSYSAGEASEVSRTRGVSLL------ARPGNS 1029

  Fly   426 TCVANRLRFHEEKQLLL--DKLQEALKST---KLLEERLKSFSSESTFSISSGSSLGSLSTASSK 485
            ...|.|.:..:|...|.  ||:...|:..   ::|:||..||:...:..    ..:..:.|..::
Zfish  1030 LVAAIRNQSQQEPVPLAYNDKIVAFLRQPNIFEVLQERQPSFARNHSLK----DKVHHIRTEGTQ 1090

  Fly   486 SALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQH--QQQRLHPVHPVLQQQQSAEVTLSPRSSL 548
            .        ::..:.|:  |:|.|    ..||::.  ....|...||        ....|||.|
Zfish  1091 R--------LEKLSCDA--DLVML----LSLFEEDIMSYVPLASFHP--------GFNFSPRCS- 1132

  Fly   549 SMETPPASPMKYNAGADQTPQALKEEPTYANALPAPPAYTAPPPVPISGVRAR---PYDLDSTVL 610
                |.:||              :..|.:....|..||............|||   ||..|
Zfish  1133 ----PGSSP--------------QNSPGFLERTPLVPACCLSGESSPGTQRARAPAPYRRD---- 1175

  Fly   611 DCMMLEAKLQKLNMGTPLNLAVAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAG 675
                .||||:..                          ...|...........:...|..:.:.
Zfish  1176 ----FEAKLRNF--------------------------YRKLEAKGYGQGPGKIKLIVRRDHLL- 1209

  Fly   676 DSGVFEASRAHLPRKELAQVQIGLKYLKQEGV----------LVVSLERANNLLALWTASADNS- 729
             .|.|....|: .||||.:.::.:.::.:||:          .::|.|..|....|:..||:::
Zfish  1210 -EGTFNQVMAY-SRKELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTY 1272

  Fly   730 --QVYLRAALLPNSLTSIR--TKALG-----------DFQKPVFNDTFAVPIT------LDKLLT 773
              |:...:|.:.|.|...|  .:.||           .|.:|.:.....:|..      ||:...
Zfish  1273 TVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPTDLSDLEYLDEEFH 1337

  Fly   774 KSLQ---------VTVVTMTGQKEEIIGTV----------QISMAEFNPE---DSTLKW------ 810
            :|||         |..:|.| ..||:.|.|          .:.:.|.|.:   :..:||
Zfish  1338 QSLQWMKENDITDVLDLTFT-VNEEVFGQVTERELKSGGTNVQVTEKNKKEYIERMVKWRVERGV 1401

  Fly   811 -----------YNVLSSKFIPSFESLDIPSTSAAAA 835
                       |.|:.|:.:..|::.::....|..|
Zfish  1402 VQQTQALVRGFYEVVDSRLVSVFDARELELVIAGTA 1437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	13/29 (45%)
		WW	103..132	CDD:278809	5/28 (18%)
		C2_Kibra	693..813	CDD:176062	35/190 (18%)
hecw1b	XP_021336549.1	HECW_N	73..192	CDD:318711
		C2_NEDL1-like	213..349	CDD:176073
		WW	771..803	CDD:197736	15/31 (48%)
		WW	952..983	CDD:197736	10/75 (13%)
		HECTc	1223..1552	CDD:214523	42/216 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900