Protein Alignment kibra and smurf2

DIOPT Version :9

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001107898.1
• Gene: smurf2 / 563633
• ZFINID: ZDB-GENE-030131-1830
• Length: 765
• Species: Danio rerio
• Alignment Length: 549
• Identity: 105/549 - (19%)
• Similarity: 189/549 - (34%)
• Gaps: 156/549 - (28%)

  Fly    37 QQQQHTHHQQQQQHHSDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGD 101
            :.|:|.::..:...|:...||:|::......|:.|::......:||.|||    .|:...:...:
Zfish   234 RSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPR----VPRDLSNVNCE 294

  Fly   102 E---LPMGWEESYDPNIGPYYINHLAQSTQLEDPR-------------QEWKTVQEQMLSDYLSA 150
            |   ||.|||.........|:::|..::||..|||             ...:...|...|.....
Zfish   295 ELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNPSPNGSRAAVEAQSSSRPGQ 359

  Fly   151 AQDQLEN-------------------KREM---FDVKQQRLLWAQEEYNHLKLAASRSSLCSSS- 192
            .::|.::                   ||::   ..:.:|.|...|.:..|.::..||..:...|
Zfish   360 LKEQAQSVVSPGNLPEDPECLTVPKYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESY 424

  Fly   193 SSMSRHDPELLRADLM-------------LARERVHQLKQELTH-----------------ITND 227
            ..:.:..|:.|...||             :|||.::.|..|:.:                 |..|
Zfish   425 RQVMKMRPKDLWKRLMVKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPD 489

  Fly   228 ISYTERGMNTLYSVGEKIN-ARENGCY-DIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIK 290
            .:.....::..:.||..:. |..:|.| |........:::|....:|...|.|..:|..|||.|.
Zfish   490 SAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWIL 554

  Fly   291 NELGRQQISEENSDLASPFDRV-CVASQTDLCGSSGENLN-----GGARFAEMAKTKWQ----YA 345
                       ::|:....|.. ||..     .:.||.:.     .|........||.:    |.
Zfish   555 -----------DNDITGVLDHTFCVEH-----NAYGEIIQHELKPNGKSIPVTQDTKKEYVRLYV 603

  Fly   346 EWRKHIKKLQQQ---LADHVERIEPGQL---ESDKDRILLIQEKEKL-LNDLNS----------- 392
            .|| .::.::.|   |......:.|..|   ..:|:..|::....|: :||..|
Zfish   604 NWR-FLRGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCGLGKIDINDWKSNTRLKHCTPDS 667

  Fly   393 -------ISLKSRSEEEKRVIHQ-------------------------TRHKLEEDLKEAYEANN 425
                   .:::|..||.:..:.|                         |.|:::.......:| :
Zfish   668 NIVKWFWRAVESYDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDASTNNLPKA-H 731

  Fly   426 TCVANRLRF--HEEKQLLLDKLQEALKST 452
            ||. ||:..  :|....|.|||..|::.|
Zfish   732 TCF-NRIDIPPYESYDKLYDKLLTAIEET 759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	8/29 (28%)
		WW	103..132	CDD:278809	9/28 (32%)
		C2_Kibra	693..813	CDD:176062
smurf2	NP_001107898.1	C2_Smurf-like	13..137	CDD:176028
		WW	159..188	CDD:278809
		WW	252..283	CDD:197736	8/30 (27%)
		WW	298..330	CDD:197736	11/31 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..375		3/33 (9%)
		HECTc	410..762	CDD:238033	69/369 (19%)
		HECTc	437..762	CDD:214523	64/342 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900