DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and yap1

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001132952.1	Gene:	yap1 / 561411	ZFINID:	ZDB-GENE-030131-9710	Length:	442	Species:	Danio rerio

Alignment Length:	441	Identity:	89/441 - (20%)
Similarity:	157/441 - (35%)	Gaps:	139/441 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PHHLR----------------------PQQQQQQHHHHHQQQQQQQHTHHQQQQQHHSDFPLPDG 59
            |||:|                      |.....||             ..|...:...|.|||.|
Zfish    80 PHHVRAHSSPASLQLGAVSPGALTSMGPANAPPQH-------------LRQSSYEIPDDMPLPPG 131

  Fly    60 WDIAKDFDGKTYYIDHINKKTTWLDPRDCY-------------TKPQTFEDCVGDELPMGWEESY 111
            |::||...|:.|:::|.::.|||.|||...             .:.|...:.....||.|||::.
Zfish   132 WEMAKTPSGQRYFLNHNDQTTTWQDPRKALLQMNQAAPASPVPVQQQNIMNPASGPLPDGWEQAI 196

  Fly   112 DPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEY 176
            ......|||||..::|...|||.:                        ..|.:.|||:..:....
Zfish   197 TSEGEIYYINHKNKTTSWLDPRLD------------------------PRFAMNQQRISQSAPVK 237

  Fly   177 NHLKLAAS-RSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDI--SYTERG--MN 236
            ...:|.:| :|.:.|.::.:......:.:..|.:.:|.:.|..|||. :.|.:  |..:.|  .|
Zfish   238 QGSQLPSSPQSGVMSGNNPIRLQQIHIEKERLRIKQELLRQRPQELA-LRNQLPTSMEQDGGTQN 301

  Fly   237 TLYSVGEKINAR-----------ENGCYDIAEVHAIREEMLK--VHKSLVSGEKVREELMRSLVQ 288
            .:.|.|...:||           .:|.|     |: |:|...  :..|..|..:..::.:.|:.:
Zfish   302 PVSSPGMGQDARNMTTNSSDPFLNSGTY-----HS-RDESTDSGLSMSSYSVPRTPDDFLNSVDE 360

  Fly   289 IK--NELGRQQISEENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHI 351
            ::  :.||...::.:.|......|.: ..:..||....||::               ..|..:.:
Zfish   361 METGDTLGPGSMATQPSRFPDYLDAI-PGTDVDLGTLEGESM---------------AVEGEELM 409

  Fly   352 KKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEE 402
            ..||:.|:            ||            :|||:.|:...::.::|
Zfish   410 PSLQEALS------------SD------------ILNDMESVLAATKIDKE 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	13/29 (45%)
		WW	103..132	CDD:278809	11/28 (39%)
		C2_Kibra	693..813	CDD:176062
yap1	NP_001132952.1	FAM181	<41..186	CDD:291891	26/118 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..89		4/8 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..116		3/31 (10%)
		WW	127..158	CDD:197736	14/30 (47%)
		WW	188..217	CDD:278809	11/28 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..254		4/23 (17%)
		Transactivation domain. /evidence=ECO:0000250\|UniProtKB:P46937	247..442		43/237 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..374		18/93 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900