DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and wwc1

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_689275.5	Gene:	wwc1 / 560785	ZFINID:	ZDB-GENE-091118-8	Length:	1112	Species:	Danio rerio

Alignment Length:	1206	Identity:	395/1206 - (32%)
Similarity:	615/1206 - (50%)	Gaps:	202/1206 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 DFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGP 117
            :.|||:||:.|:|||||.|||||||:.|:|:||||..|||.||.||:|||||:||||:|||::|.
Zfish     5 ELPLPEGWEEARDFDGKVYYIDHINQTTSWIDPRDRQTKPLTFADCIGDELPVGWEEAYDPHVGA 69

  Fly   118 YYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLA 182
            ||::|..:||||||||.:|:..||.||.|||:..|:.|..::|::.||:|||..||:||..|..|
Zfish    70 YYVDHNTKSTQLEDPRAQWQREQELMLHDYLNVVQEALSAQKEIYQVKEQRLRLAQQEYRQLNDA 134

  Fly   183 -----ASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSVG 242
                 :|::||.|.|||.|::|||:|:|:::.|:.||::||::|.::..::.|.|:|..||..:.
Zfish   135 WRDKSSSQTSLNSRSSSSSKYDPEILKAEIVTAKSRVNKLKRDLAYMKQELHYKEQGFETLKEID 199

  Fly   243 EKINARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIK----------NELGRQQ 297
            .|:::..:| |.:.|..||.:|:..:..::.||||.::||||.|..:|          ::|....
Zfish   200 HKVSSASHG-YKLHEAQAILKEVKSIKDAISSGEKEKQELMRKLAVLKDGFQLDYGSQSDLWASN 263

  Fly   298 ISEENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHV 362
            .|..||:|:.|.......||||:   ..:.::...:.||..:...:|.|.::.|..::.|:|...
Zfish   264 PSLANSNLSLPRLYSDAESQTDI---PAQFVSSSNKLAEKVRLSLKYEEAKRRIANIEVQIAKLD 325

  Fly   363 ERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTC 427
            ....||.|:.::||::||.|||:||.:|..:....|:..|...|...:.:||:||:.|.:..:..
Zfish   326 SEAWPGLLDPERDRLILINEKEELLKELQYVRPCKRAPNEAEKIESEKKRLEKDLQAARDNQSKA 390

  Fly   428 VANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSL---------STAS 483
            :..|||.|..:..|:.:|:|.::....|..:|||.|: ||.|.|||||.|||         |:..
Zfish   391 LTERLRLHYRRNKLVKELEETVRVASSLHTQLKSLSA-STLSCSSGSSRGSLTSSRGSLANSSLG 454

  Fly   484 SKSALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQHQQQRLHP------VHPVLQQQQSAEV-- 540
            |.|:|||||:|::...:..|    |.:.:...:.|:.......|      :|.......|.::
Zfish   455 STSSLSFTDVYLEQPELGDP----DFQNKLDSILQEGSTSGYRPSSSITTIHENEVSSSSVQIGG 515

  Fly   541 ---------------------TLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALPAP 584
                                 :||||||||..:||.||:                .|.|:.| :.
Zfish   516 GPGVGQRTQVLRLSETPHSMNSLSPRSSLSSLSPPCSPL----------------VTEASFL-SG 563

  Fly   585 PAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAVAPLSPISEKPSLLDLPQ 649
            ..::.|         |...|||   |...::|.:|::......||..              |..|
Zfish   564 EVFSGP---------ASQLDLD---LQTRLMELRLEEDQQQGQLNYQ--------------DNKQ 602

  Fly   650 EML----SRSSSTSNTR---------SVSAAVSNESVAGDSGVFEAS--RAHLPRKEL------- 692
            |.:    |...:.:.||         .|::|||:|||||||||:|.|  |..||.::|
Zfish   603 ESIMAVESSKDAVTQTRGSGPGSKKAGVTSAVSDESVAGDSGVYEPSEKRPGLPVEQLLAFDDGS 667

  Fly   693 ----AQVQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSLT---SIRTK-A 749
                ||:::||||..:|....|.:.:.:|..||  :...|..:|:|..:||.|.|   ..||. |
Zfish   668 SASSAQIKLGLKYEVKEKRFTVFVMQLSNYSAL--SLPANQNIYVRVVVLPCSETVRCLFRTHCA 730

  Fly   750 LGDFQKPV-FNDTFAVPITLDKLLTKSLQVTVVTMT-GQKEEIIGTVQISMA--EFNPEDSTLKW 810
            |.  |:|| ..:.|::.::...|..|:|::.|.|.: ..:|..:...|||:|  |::.|..| ||
Zfish   731 LP--QEPVELKEAFSLQVSSTALRQKTLRIDVCTTSKSGREHCLAGAQISLADEEYSEEWCT-KW 792

  Fly   811 YNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQTSTLTRNQAPC 875
            ||:|:..::|..:                        |..:|   .|.......|...:.|.|.|
Zfish   793 YNLLNCTYMPEMD------------------------GKQKE---TEMPALQELTPASSENAASC 830

  Fly   876 ME--LQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSSMLHAYLQNMKQEF 938
            ||  ..|...||.|. |.:...|...|.::.||...||.|...:      ...|.|....:..|.
Zfish   831 MENVPLEDWPAETLE-GDVFVDEEGSDGEEGEEFYPDDCQWEQE------EEPLKAGPTTVIAEK 888

  Fly   939 ADKETNTD------RAYLPEKSR----GQSQLMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSD 993
            .:|||:.|      ....|::.|    .|:..|....:.||:||:|.   .:::|.||:||||||
Zfish   889 VNKETSMDGLPHSTSVVRPKERRHDVHQQNPFMRGNTIIRSKTFSPG---PQSQYICRINRSDSD 950

  Fly   994 SAMHCGVAPHTFQRGAAERRSLRFHSKAPKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQI 1058
            |:.....:|  |.|.|:||||:|. .|.|..|..|  ..:.|||||||||||...::...|.:::
Zfish   951 SSTLSKKSP--FVRNASERRSVRM-KKPPMQVKGL--DGLLRTSLDLELDLQVTRTRHSRLTEEL 1010

  Fly  1059 AKLQNLKEVLQKACENKDPLVAAWAIENEEFQRLVARADPAKCPE---ERQLQKLLMKTAKEIHK 1120
            ..|:.|||.::||.:....::..|..|:|.|..|:..|:.....|   |::::|::...||::||
Zfish  1011 RVLRELKEQMEKARQQGQHVLPTWVQEDERFCLLLKHAERQTQEEQLQEKRVEKMMRAAAKDVHK 1075

  Fly  1121 LRKTKVPKGCPDLVSFKEKITFFTRKGLSVPELPSE 1156
            :|...: |..|.:.||:||:.||||..::||:||::
Zfish  1076 IRGQSL-KEVPGVQSFREKMAFFTRAKINVPDLPAD 1110

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	20/29 (69%)
		WW	103..132	CDD:278809	18/28 (64%)
		C2_Kibra	693..813	CDD:176062	42/127 (33%)
wwc1	XP_689275.5	WW	9..39	CDD:238122	20/29 (69%)
		WW	55..84	CDD:278809	18/28 (64%)
		C2_Kibra	672..795	CDD:176062	42/127 (33%)
		PHA03281	902..>1102	CDD:165538	74/208 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592605
Domainoid	1	1.000	249	1.000	Domainoid score	I2092
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	520	1.000	Inparanoid score	I1228
OMA	1	1.010	-	-		QHG50236
OrthoDB	1	1.010	-	-		D181722at33208
OrthoFinder	1	1.000	-	-		FOG0003726
OrthoInspector	1	1.000	-	-		otm26551
orthoMCL	1	0.900	-	-		OOG6_103792
Panther	1	1.100	-	-	O	PTHR14791
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4620
SonicParanoid	1	1.000	-	-		X1418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800