Protein Alignment kibra and herc5.1

DIOPT Version :9

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_017211386.1
• Gene: herc5.1 / 559981
• ZFINID: ZDB-GENE-090311-56
• Length: 884
• Species: Danio rerio
• Alignment Length: 676
• Identity: 132/676 - (19%)
• Similarity: 239/676 - (35%)
• Gaps: 226/676 - (33%)

  Fly   369 QLESDKDRILLIQEKEKLLN---DLNSISLKSRSEEEKRVIHQTRHK---LEEDLKEAYEA---- 423
            |.|..||....|::.:|:.:   .||...||:|.:..    :||..:   |:..|.|:..|
Zfish   266 QCECGKDPRKAIKDLKKVFSSAASLNGSFLKTRHDGH----YQTSEEYCGLDFGLVESSIATLSR 326

  Fly   424 NNTCVANRLRFHEEKQLLLDKL------QEALKSTKLLEERLKSFSSESTFSISSGSSLGSLSTA 482
            |...::..|:..:|.  ||..|      :|:|:...||.|.:....||....::  .:|.|....
Zfish   327 NERLISTVLKVLQES--LLPTLNPNPTGEESLRLYILLPELISHLKSEQKAELT--EALASKILN 387

  Fly   483 SSKSALSFTDIYIDPFAVDSPIDVVDLRRRS----------------------------QRLFQ- 518
            .|.:||...:||......|...::|.|.:::                            ||::|
Zfish   388 LSPAALRVLEIYWSKLPDDWLKNLVKLFKKASAKFFGRIIVENVNNVAKTHMLKFVEILQRVYQV 452

  Fly   519 -----QHQQQRLHPVHPV-----LQQQQSAEVTLS-PRSSLSMETPPASPMKYNAGADQTPQALK 572
                 ::.::|...:|.|     :.|..:|:|..: |..:|:.:. .|...:.|| .::|.:.|.
Zfish   453 CCSANRNIKKRYFIIHEVNNLLDVLQTMNADVNNNWPWFNLTGQI-HALEAQRNA-YEETFRKLT 515

  Fly   573 EEPTYANALPAPPAYTAPPPVPISGVRARPYD--LDSTVLDCMMLEAKLQKLNMGTPLNLA---- 631
            ..|...| |.|..:|          :|.|.:.  .:.||....:||..|..||.||..:|.
Zfish   516 SFPCIFN-LEAKCSY----------MRNRVWKGRFELTVRRTALLEDCLCLLNPGTQQHLRDKWL 569

  Fly   632 -------VAPLSPISEKPSLLDLPQEMLSRSSS----TSNTRSV--------------------S 665
                   |:..:.:.::...|::.:|:...:|.    ..|...:                    .
Zfish   570 SILFTENVSKRTDVHKRDFFLNVFKELCDPASQLFMYNDNETMIWFPAKLTVEKKKYFLFGILCG 634

  Fly   666 AAVSNESVAGDSGVFEASRAHLP-----RKELAQVQIGLK-YLKQEGV----LVVSLERANNLL- 719
            .|.:|.||           .:||     .|:|..::..|: :::...|    |...||.:|::|
Zfish   635 LAFNNSSV-----------VNLPFPLALFKKLLNIKPSLEDFIEFNPVHGRSLQYILEYSNDVLE 688

  Fly   720 -------ALWTAS------ADNSQVYLRAALLPNSLTSIRTKALGDFQKPVFNDTFAVPITLDKL 771
                   .:|:.|      |:..|         :..||.|||.:.::...:||.  :|....::.
Zfish   689 ESSLPLTIIWSGSELDLDPAEPEQ---------HITTSNRTKFVDEYVDHIFNQ--SVKEAFEEF 742

  Fly   772 ---LTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPEDSTLKWYNVLSSK---------------- 817
               ..:..:..:|.|. :.||:.| |.:...|::        :|:|...
Zfish   743 RRGFFRGCEKRLVEMF-EPEELRG-VLVGNEEYD--------WNILKQNTTYEGVFNADHPVIIS 797

  Fly   818 ------------------FIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQ 864
                              |:..||.:.|...||........|       |:.|:...|
Zfish   798 FWEVFDDLTPNEKKSFLLFLTGFERVPILGMSAVKMRVTHLA-------NSTEDHLPE------- 848

  Fly   865 TSTLTRN---QAPCMELQEQMAAELL 887
              |||.:   |.|..|.:|.:.|:::
Zfish   849 --TLTCHSLLQLPKYEKRETLRAKVI 872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809
		C2_Kibra	693..813	CDD:176062	26/141 (18%)
herc5.1	XP_017211386.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900