DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and WWC3

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_056506.2	Gene:	WWC3 / 55841	HGNCID:	29237	Length:	1092	Species:	Homo sapiens

Alignment Length:	1189	Identity:	345/1189 - (29%)
Similarity:	555/1189 - (46%)	Gaps:	251/1189 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 INHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHL-KL-- 181
            ::|:.:.||:||||::|:..||:||.:||..||:.|..|:|::.:||||...|||||..| |:
Human     1 MDHINKLTQIEDPREQWRREQERMLKEYLIVAQEALNAKKEIYQIKQQRFELAQEEYQQLHKMCE 65

  Fly   182 --AASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSVGEK 244
              :.|.:|..|..|:.:::||..::|::...|:|:.:||:|||.:..::.|.|:|:.||..:..|
Human    66 DDSRSYASSFSGYSTNTKYDPHQIKAEIASRRDRLSRLKRELTQMKQELQYKEKGVETLQEIDRK 130

  Fly   245 INARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENS------ 303
            :::.... |.:.|..||..|:..:.|::.:|||.|.:||.||.::.:.. :...|..:|
Human   131 MSSTHTS-YKLDEAQAIMSELRTIKKAICTGEKERRDLMHSLAKLTDSF-KNSCSVTDSLVDFPH 193

  Fly   304 ------DLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHV 362
                  |...|.......||||:.|..  ..:...|..:..:..|||.|.||.:..:|||||...
Human   194 HVGVPGDAGVPQQFCDAGSQTDIIGEF--VFDDKTRLVDRVRLNWQYEEARKRVANIQQQLARLD 256

  Fly   363 ERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTC 427
            ....|...|:|:||:.||:|||.||.:|..|..:.||..:...:.:.|.:|||:|:.|...:...
Human   257 NESWPSTAEADRDRLQLIKEKEALLQELQLIIAQRRSAGDVARLEEERERLEEELRRARATSAQG 321

  Fly   428 VANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSL-----STASSK-- 485
            ...|:...|::..||.:|:||.:.|..|:.:|||..: ||.::|||||.|||     |.|||:
Human   322 ATERILLQEKRNCLLMQLEEATRLTSYLQSQLKSLCA-STLTVSSGSSRGSLASSRGSLASSRGS 385

  Fly   486 -SALSFTDIY----------------------IDPFAVDSPIDVVDLRRRSQRLFQQ-------H 520
             |::||||||                      .|....|:|             |.:       |
Human   386 LSSVSFTDIYGLPQYEKPDAEGSQLLRFDLIPFDSLGRDAP-------------FSEPPGPSGFH 437

  Fly   521 QQQRLHPVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTP--QALKEEP--TYANAL 581
            :|:|      .|...||. .:||.|||||..:||:||:       .||  .|.::.|  ..|::.
Human   438 KQRR------SLDTPQSL-ASLSSRSSLSSLSPPSSPL-------DTPFLPASRDSPLAQLADSC 488

  Fly   582 PAP--------------------PAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGT 626
            ..|                    |...|..|..:.|....|::                   .|.
Human   489 EGPGLGALDRLRAHASAMGDEDLPGMAALQPHGVPGDGEGPHE-------------------RGP 534

  Fly   627 PLNLAVAPLS-PISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFE-ASRAHLPR 689
            |      |.| |:....:|.:...:.|.|     ..|.:||.:|:.|:|.|||||| .::.:...
Human   535 P------PASAPVGGTVTLREDSAKRLER-----RARRISACLSDYSLASDSGVFEPLTKRNEDA 588

  Fly   690 KELA----------QVQIGLKYLKQEG--VLVVSLERANNLLALWTASADNSQVYLRAAL----- 737
            :|.|          |:.:||  |:..|  .|:|.:.:..|...|  |..::.:|::|..|
Human   589 EEPAYGDTASNGDPQIHVGL--LRDSGSECLLVHVLQLKNPAGL--AVKEDCKVHIRVYLPPLDS 649

  Fly   738 -LPNSLTSIRTKALGDFQKP-VFNDTFAVPITLDKLLTKSLQVTVVTMTGQ-KEEIIGTVQISMA 799
             .||:..|   ||| :||.| |||:.|.:|:....|..||||:.|.::|.| :||::|..||::|
Human   650 GTPNTYCS---KAL-EFQVPLVFNEVFRIPVHSSALTLKSLQLYVCSVTPQLQEELLGIAQINLA 710

  Fly   800 EFNP-EDSTLKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSS 863
            :::. .:..|:|::|      ..|.|.: ||.:..|..|  ..|:|.:|.:....|..    |.:
Human   711 DYDSLSEMQLRWHSV------QVFTSSE-PSRTREAGCA--GESSARDPAHTISISGK----TDA 762

  Fly   864 QTSTLTRNQAPCMELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVS---DVGLMNSSS 925
            .|..|.|..|....::.::|.|...|....|.....:..:::.|.:.::...:   |.|..|.:.
Human   763 VTVLLARTTAQLQAVERELAEERAKLEYTEEEVLEMERKEEQAEAISERSWQADSVDSGCSNCTQ 827

  Fly   926 MLHAYLQN--------MKQEFA------------------DKETNTDRAYLPEKSRGQSQLMDDR 964
            ....|.:.        :...||                  ||||||:..:|.|    .:.|:.:|
Human   828 TSPPYPEPCCMGIDSILGHPFAAQAGPYSPEKFQPSPLKVDKETNTEDLFLEE----AASLVKER 888

  Fly   965 P--------------VKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHTFQRGAAERRSL 1015
            |              :.|||||:|.   ::::|.|||.||||||:.....:|  |.|...|||:|
Human   889 PSRRARGSPFVRSGTIVRSQTFSPG---ARSQYVCRLYRSDSDSSTLPRKSP--FVRNTLERRTL 948

  Fly  1016 RFHSKAPKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACENKDPLVA 1080
            |:......|:.:|    :.||||||||||||..::...||:::..|:.|::.|:.|.......:.
Human   949 RYKQSCRSSLAEL----MARTSLDLELDLQASRTRQRQLNEELCALRELRQRLEDAQLRGQTDLP 1009

  Fly  1081 AWAIENEEFQRLVARAD------PAKCPEERQLQKLLMKTAKEIHKLR--KTKVPKGCPDLVSFK 1137
            .|.:.:|..:.|:..|:      ......|:..:|:|.|.:|||::||  ..|.|   ..:.:|:
Human  1010 PWVLRDERLRGLLREAERQTRQTKLDYRHEQAAEKMLKKASKEIYQLRGQSHKEP---IQVQTFR 1071

  Fly  1138 EKITFFTRKGLSVPELPSE 1156
            |||.||||..:::|.||::
Human  1072 EKIAFFTRPRINIPPLPAD 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809	4/11 (36%)
		C2_Kibra	693..813	CDD:176062	44/140 (31%)
WWC3	NP_056506.2	THOC7	<4..119	CDD:283305	44/114 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..384		12/20 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..488		25/92 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..544		10/58 (17%)
		C2_Kibra	602..725	CDD:176062	43/130 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156963
Domainoid	1	1.000	262	1.000	Domainoid score	I1950
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	542	1.000	Inparanoid score	I1181
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50236
OrthoDB	1	1.010	-	-		D181722at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41793
orthoMCL	1	0.900	-	-		OOG6_103792
Panther	1	1.100	-	-	O	PTHR14791
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.770