DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and LOC556872

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_021334149.1	Gene:	LOC556872 / 556872	-ID:	-	Length:	1472	Species:	Danio rerio

Alignment Length:	1346	Identity:	261/1346 - (19%)
Similarity:	427/1346 - (31%)	Gaps:	420/1346 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 DGWDIAKDFDGKTYYIDHINK--KTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYI 120
            :.|::.....|..||.||..|  .::||:.|                     ..|.|....|.||
Zfish   285 ENWEMMYSDSGNAYYKDHHLKPSSSSWLNRR---------------------AHSRDNVCMPEYI 328

  Fly   121 NHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASR 185
            :|......|.|.:.:...|.|         ..||....|. |.| ..||:.....:....:..||
Zfish   329 SHSCIWQSLTDLQSQCVQVAE---------FTDQPSELRG-FSV-HTRLVKGARGFGFNIVGGSR 382

  Fly   186 SSLCSSSSSMSRHDPELLR-ADLML-----------ARERVHQLKQELTHITNDISYTERGMNTL 238
            ........|::...|..|. ||:::           .::.|..||......|.|| ...||...|
Zfish   383 RREFLQIYSITPGGPSTLNTADILVYINDTCVLGYSHKDVVEMLKAIPIGHTVDI-MVRRGYPML 446

  Fly   239 YSVGEKINARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENS 303
            |:        ..||..::.......:....|  |......:.:....|...:..|      ..||
Zfish   447 YN--------SEGCPKMSNPRLTASQNQSPH--LPPPTTTQPQAQAPLPYAQLHL------NHNS 495

  Fly   304 DLASPFDRVCV------ASQTDLCG--------------SSGENLNG-GARFAEMAKTKWQYAEW 347
            ...:.|||...      ||:..|..              ||.:..|| |:.|....:|
Zfish   496 PPWADFDRGSSRNLRVRASRFSLDANGNSPPFASPPRPPSSYQGSNGYGSGFLRPPRT------- 553

  Fly   348 RKHIKKLQQ-QLADHVERIEPGQLESDKDRILLI-QEKEKLLNDLNSISLKSRSEEEKRVIHQTR 410
            .:.|::||. :||.          :||.:.:..| ..:...:.:.|:.||   |......:|..:
Zfish   554 ARSIRRLQSAELAS----------QSDSEVVSAIGSHRASFIRNHNNNSL---STPPPLRLHSFK 605

  Fly   411 HKLEEDLKEAYEANNTCVANRLRF-HEE--------------KQLLLDKLQEA-LKSTKLLEERL 459
            .. |.||    .::.....:||.. |.|              :...|.|.|.: |.....:....
Zfish   606 SS-ESDL----SSSTPPPISRLPLPHTELSPGPVSFSPGGGRRYSHLRKPQNSMLTPPSSVHSDG 665

  Fly   460 KSFSSESTFSISSGSSLGSLSTASSKSALSFTDI-------YIDPFAV----------------- 500
            ..|:...|.|.||||...|:.:..:.||:..:.:       .:.|.|:
Zfish   666 PYFTFNGTASASSGSPNSSIPSPGALSAVIGSGVGGMAAGGELVPVALAKCERGSNMGFSVTAGG 730

  Fly   501 -----------------------DSPIDV--VDLRRRS----QRLFQQHQQQRLHPVHPVLQQQQ 536
                                   |:.:.:  .|::..|    ||:.|:|.::
Zfish   731 HGGRQTLVKKVWDHRQCNGLQSGDAVVKINGADVQSLSFAQVQRILQEHTKK------------- 782

  Fly   537 SAEVTL-----------SPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALPAPPAYTAP 590
             .||.|           || ||:...|||..    .:.:|.........|...|:|..|    :|
Zfish   783 -GEVILLVYRGPSNYSNSP-SSVRRLTPPPP----RSASDSEVPFTDSMPLSRNSLTPP----SP 837

  Fly   591 PPVPISGVRARPYDLDSTVLDCMMLEAK--LQKLNMGTPLNLAVAPLSPISEK---PSLLDLPQE 650
            ..|..|.|::..: |||..: .:.||.:  :...:.||.|    :|.....||   |:|.....|
Zfish   838 ALVRSSLVQSTSF-LDSVPV-TLTLEPRDWMSSEDGGTVL----SPRVKTEEKEQPPALRGYEVE 896

  Fly   651 MLSR----------SSSTSNTRSVS--------------AAVSNESVAGD--SGVFEASRAHLPR 689
            :..:          |....|.::||              ||.|.:...||  ..|...|..:||.
Zfish   897 LKRKPGEGFGFVIASQDVENVKAVSLLPHRFVTVRRGSPAARSGQIRPGDRLEAVDGRSVVNLPH 961

  Fly   690 KELAQVQIGLKYLKQEGVLVVSLERANNLLALW---TASADNSQVYLRAALLPNSLTSIRTKALG 751
            :||||:                |.||.|.|.|.   .|||.:|:   ||...|:.......|:
Zfish   962 RELAQI----------------LRRAGNTLRLTIVPRASAHSSE---RADYDPDYKNRKTHKS-- 1005

  Fly   752 DFQKPVFNDTFAVPITLDKLLTK---SLQVTVVTMTGQKEEIIGTVQISMAEFNPEDSTLKWYNV 813
               ||..:.|....:.|::..|.   ||:       |..|..:|...:.:.|..|...
Zfish  1006 ---KPKQDATRYYSVELERGPTGFGFSLR-------GGSEYNMGLYVLGLMEGGPASR------- 1053

  Fly   814 LSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNN------------REESSDESTITSSQTS 866
             |.|...|.:.::|...|||....:.|.......|:.            .:...|..|..||...
Zfish  1054 -SHKIQVSDQLVEINGDSAAGMTHSQAVEQIRTGGSRIHLVFKRGNGYVPDYDRDHITAVSSSPQ 1117

  Fly   867 TLTRNQAPCMELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSSMLHAYL 931
            .|..|.|.....:.|..|    ...|.:||.::....:..|.       ||.|...|.:.|....
Zfish  1118 PLQSNLAAVSHHRPQRDA----TSSLQKPEKTNRGWKEPRER-------SDGGDRESPARLKGDR 1171

  Fly   932 QNMKQEFADKE---------TNTDRAYLPEKSRGQSQLMDDRPVKRSQTFTPSEAFSKNRYNCRL 987
            |..::...|.|         .||.|.:..|..:.:....:.|.:::          ...|...|.
Zfish  1172 QGRRRRSRDDERRRRSYSLPRNTPRRHSDESMKVEKVERNGREMEK----------GNKRSVDRP 1226

  Fly   988 NRSDSDSAMHCGVAPHTFQRGAAERRSLRFHSKAPKSVTKLHHTHIPRTSL--------DLELDL 1044
            .||.|:..:.             ||:.....||..:::.|  | .:|:..|        :.|.|.
Zfish  1227 KRSKSEERVR-------------ERKREGDESKNTQTINK--H-RLPQPKLQWEENEEEEEEWDG 1275

  Fly  1045 QAQHSKLYFLNDQIAKLQNLKEVLQKACENKDPLVAAWAIENEEFQRLVARAD---PAKCPEERQ 1106
            :.:       .:...:.:.||:..:               |.||...|.:.:|   .::...:..
Zfish  1276 ETE-------QEWTRERERLKDKKR---------------EREEIASLDSESDGELESENESKMN 1318

  Fly  1107 LQKLLMKTAKEIHKLRKTKVPKGCPDL---------VSFKEKITFFTRKGLSVPELPSEFTLPEA 1162
            ::.|..:|.|:.|:           |:         .||.:::.:     |.:..||.:   .::
Zfish  1319 VEVLEWETNKKTHQ-----------DISEELNREQDTSFHKRLPY-----LGIRVLPPD---TQS 1364

  Fly  1163 NPI-----EEEEEEEDENEFYNSAETAIAINTALVASSNRNKNLSE 1203
            .|:     ...||...:|||..:....:....:..|.|....::||
Zfish  1365 RPLRRISGHSLEEPVGKNEFNRTPFAFLTTEQSDYAESESGASVSE 1410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	9/30 (30%)
		WW	103..132	CDD:278809	7/28 (25%)
		C2_Kibra	693..813	CDD:176062	28/125 (22%)
LOC556872	XP_021334149.1	PDZ_signaling	24..88	CDD:238492
		NK	111..>190	CDD:327404
		PDZ_signaling	365..440	CDD:238492	15/75 (20%)
		PDZ	722..791	CDD:238080	10/82 (12%)
		PDZ_signaling	893..980	CDD:238492	24/102 (24%)
		PDZ_signaling	1017..1093	CDD:238492	18/90 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900