DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and PLEKHA5

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001243399.1	Gene:	PLEKHA5 / 54477	HGNCID:	30036	Length:	1282	Species:	Homo sapiens

Alignment Length:	1463	Identity:	257/1463 - (17%)
Similarity:	490/1463 - (33%)	Gaps:	466/1463 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCV------GDELPMGWEESYDPN 114
            ||..|.......|:.::|:...|.||||       .|.|.|..|      ..:||.||||:|...
Human    12 LPRSWTYGITRGGRVFFINEEAKSTTWL-------HPVTGEAVVTGHRRQSTDLPTGWEEAYTFE 69

  Fly   115 IGPYYINH----------------------------LAQSTQLEDPRQEWKTVQE----QMLSDY 147
            ...|||||                            :|..|..|...:....:.|    .:.|||
Human    70 GARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPISMINEASNYNVTSDY 134

  Fly   148 ----------LSAAQDQLEN--KREMFDVKQQ------RLLWA-QEEYNHLKLAASR----SSLC 189
                      .|.|..::.|  ||.. .:|:.      |..|. :::...:||...|    |.||
Human   135 AVHPMSPVGRTSRASKKVHNFGKRSN-SIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLC 198

  Fly   190 SSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISY--TERGMNTLYSVGEKINARENGC 252
            .......:.  |.:...::|...::..|..| .||....::  ....|.|.|.           |
Human   199 LFYYRDEKE--EGILGSILLPSFQIALLTSE-DHINRKYAFKAAHPNMRTYYF-----------C 249

  Fly   253 YDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDLAS----PFDRVC 313
            .|..      :||....|:::....|:.|.::   :|.......:|:.||:....    |..||.
Human   250 TDTG------KEMELWMKAMLDAALVQTEPVK---RITFNFRVDKITSENAPTKETNNIPNHRVL 305

  Fly   314 VASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRIL 378
            :                        |.:.|..:..|.:.|::::.|...|:.  |..:..:||
Human   306 I------------------------KPEIQNNQKNKEMSKIEEKKALEAEKY--GFQKDGQDR-- 342

  Fly   379 LIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVANRLRFH------EE 437
                   .|..:||:.|.|                   |...||:.:.|.|..:.:.      .|
Human   343 -------PLTKINSVKLNS-------------------LPSEYESGSACPAQTVHYRPINLSSSE 381

  Fly   438 KQLL---------------------LDKLQEALKSTKLLEERLK----SFSSESTFSISSGSSL- 476
            .:::                     .|::.:...|.:.||:.:|    ....|.|..:.|..:|
Human   382 NKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLP 446

  Fly   477 GSLSTASSKSALSFTDIY----------------IDPFAVDSPIDV-VDLRRRSQR------LFQ 518
            .::.:..::....:.:.|                :.|...|..:.. .:.:|||.|      |::
Human   447 RNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYE 511

  Fly   519 QHQQQRLH-----PVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYA 578
            ..|:|..:     |.|..|    |:..|:...|..:|.:.|.||   :.|:....|....:.||.
Human   512 WQQRQFYNKQSTLPRHSTL----SSPKTMVNISDQTMHSIPTSP---SHGSIAAYQGYSPQRTYR 569

  Fly   579 NALPAP---------PAYTA--PPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAV 632
            :.:.:|         ..:.|  |..|.:...|:.|..|....:....|:.|       ||..|.:
Human   570 SEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGK-------TPEELTL 627

  Fly   633 APLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRKELAQVQI 697
            .          |:.|.::....||...:|.:....:..|             ||.|:.|:
Human   628 L----------LIKLRRQQAELSSIREHTLAQLMQLKLE-------------AHSPKNEI----- 664

  Fly   698 GLKYLKQEGVLVVSLERANN--LLALWTASADNS-------QVYLRAALLPNSLTSIRTKALGDF 753
             |.:..|...:.:..:...|  ::.:.....:||       |.:||.....:.....:.:..|
Human   665 -LSHHLQRNTIYLDHQMKENEPIITMVHTMIENSALRPQLYQQFLRQKSKISLYCLSQDEGRG-- 726

  Fly   754 QKPVFNDTFAVPITLDKLLTKSLQVTV-VTMTGQKEEIIGTVQISMAEFNPEDSTLKWYNVLSSK 817
                         ||.|...:.:.:.. ::...::::::..::..:.:.:.|..||:      ..
Human   727 -------------TLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLE------QA 772

  Fly   818 FIPSFESLDIPSTSAAAAAAAVAASNAPNPG---NNREESSDESTITSSQTS--------TLTRN 871
            .:.:.:.:::.:.:.||....|...:....|   ..||.|...:.:..:...        |:|||
Human   773 LLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRN 837

  Fly   872 QAPCMELQEQMAAELLGLGPLNEPECSDDDDDDEEEEL-------------DDKQLVSDVGLMNS 923
            |     :|||    |..||.: :.|.:.......::||             ..::..:::|::.|
Human   838 Q-----MQEQ----LDHLGEV-QTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGS 892

  Fly   924 SSMLHAYLQNMKQEFADKETNTDRAY-----------LPEK-------SRGQSQLMDDRPVKRSQ 970
            ........:|.::|.........|:|           ||..       |||...|.:::.:.:.|
Human   893 KPFSTVKYKNEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKMYQVQ 957

  Fly   971 TFTPSEAFSKNRYNC----RLNRSDSD-----------------------------SAMHCGVAP 1002
                  .:.:|..:|    ||.:|:.:                             |....||.|
Human   958 ------GYPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVP 1016

  Fly  1003 HTFQRGAAE-------------RRSLRFHSKAPKSVTK---LHHTHIPRTSLDLELDLQAQHSKL 1051
            ...:....|             ::.:...::.|:|..:   |..:..||.:::.:::...:|
Human  1017 PRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRH--- 1078

  Fly  1052 YFLNDQIAKLQNLKEVLQK-ACENKDPLVAAWAIENEEFQRLVARADPAKCPEERQLQKLLMKT- 1114
                 |.|.|:..|:.|.. ...::.||.:...:.:..|     |....:..::::|...:.:.
Human  1079 -----QQACLREKKKGLNVIGASDQSPLQSPSNLRDNPF-----RTTQTRRRDDKELDTAIREND 1133

  Fly  1115 --------AKEIHKLRKTKVPKGCPDLVSFKEKITFFTRKGLSVP-ELPSEFTLPE---ANPIEE 1167
                    |.||.:|::|:     |..|.|.:::    :|..::. |:..|   ||   .|.:|.
Human  1134 VKPDHETPATEIVQLKETE-----PQNVDFSKEL----KKTENISYEMLFE---PEPNGVNSVEM 1186

  Fly  1168 EEEEEDENE------FYNSAETAIAINTALVASSNRNKNLSEHPHRATSGAVPKIPAPVVTPAAT 1226
            .::|.::::      |....||..|           |....|||...|..:|.:....|::..:|
Human  1187 MDKERNKDKMPEDVTFSPQDETQTA-----------NHKPEEHPEENTKNSVDEQEETVISYEST 1240

  Fly  1227 PAATPAATPAATSAATP----AATPVVSPAAQP 1255
            |..:......|..:.:|    :|:||  |:.||
Human  1241 PEVSRGNQTMAVKSLSPSPESSASPV--PSTQP 1271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	9/29 (31%)
		WW	103..132	CDD:278809	15/56 (27%)
		C2_Kibra	693..813	CDD:176062	15/129 (12%)
PLEKHA5	NP_001243399.1	WW	12..41	CDD:278809	10/35 (29%)
		WW	58..87	CDD:278809	12/28 (43%)
		PH_PEPP1_2_3	164..267	CDD:270068	22/122 (18%)
		PH	170..266	CDD:278594	22/115 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900