DRSC/TRiP Functional Genomics Resources

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Protein Alignment kibra and Wwc2

DIOPT Version :9

Sequence 1:NP_001034055.1 Gene:kibra / 41783 FlyBaseID:FBgn0262127 Length:1288 Species:Drosophila melanogaster
Sequence 2:NP_598552.2 Gene:Wwc2 / 52357 MGIID:1261872 Length:1187 Species:Mus musculus


Alignment Length:1264 Identity:398/1264 - (31%)
Similarity:621/1264 - (49%) Gaps:251/1264 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 PLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYY 119
            |||.||:.|:|:|||.:||||..::|:|:||||..|||.:|.||||||||.|||..:||.||.||
Mouse    11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQIGAYY 75

  Fly   120 INHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHL----- 179
            |:|:.::||:||||::|:..||:||.||||.|||.|..::|::.||:|||..|.:||..|     
Mouse    76 IDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQRLALALDEYVRLNDAYK 140

  Fly   180 KLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSVGEK 244
            :.::|.:||.|.|||.:::||::|:|::...:.||.:||:||:|:..::.|.::|..||..:.||
Mouse   141 EKSSSHTSLFSGSSSSTKYDPDILKAEISTTQLRVKKLKRELSHMKQELLYKQQGFETLQQIDEK 205

  Fly   245 INARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQ----------IS 299
            ::..::| |::.|..||..|:..:.|::.||||.:::||:||.:::......|          .|
Mouse   206 MSGGQSG-YELNEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERFHLDQNMGSSEPDLRSS 269

  Fly   300 EENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVER 364
            ..||.|:.....:...|||.:.|..|  :...:..||..:...||.|.::.:..|:.:|:.....
Mouse   270 PVNSHLSLSRQTLDAGSQTSISGDIG--VRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLDGE 332

  Fly   365 IEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVA 429
            ..||.|:.:|::::||.|||:||.:|..|:.:.||:||...:...|..|||:|..|..:.:..:.
Mouse   333 AWPGALDIEKEKLMLINEKEELLKELQFITPQKRSQEELERLEAERQHLEEELMAARGSPSRALT 397

  Fly   430 NRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSL---------STASSK 485
            .||:..|:::.||.||:|..|.|..|..:|:|.|| ||.|:|||||||||         |:..|.
Mouse   398 ERLKLEEKRKELLQKLEETTKLTTSLYSQLQSLSS-STLSMSSGSSLGSLASSRGSLNTSSRGSL 461

  Fly   486 SALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQHQQQRLHPVHPV------------------- 531
            ::||.:::|     ..|..|.:|...:.:..|...::....|..|:                   
Mouse   462 NSLSSSELY-----YSSQGDQMDTDYQYKLDFLLQEKGGYIPSGPITTIHENEVVKSPSQPGQSG 521

  Fly   532 --------------LQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALP 582
                          |.:...:..:||.|||||..:||.||:..:                 :..|
Mouse   522 LCGVGVTASSHTTPLTEASKSVASLSSRSSLSSLSPPGSPLVLD-----------------SVFP 569

  Fly   583 APPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAV------APLSPISEK 641
            .....|:|...|.        |.:    ||   |...:..::|...|.|:      ....|:.|.
Mouse   570 GSSHDTSPHQFPT--------DFE----DC---ELSRRFADVGLGENQALLDSDSGGASQPLLED 619

  Fly   642 PSLLDLPQEMLSRSSST---------------SNTRSVSAAVSNESVAGDSGVFEASRAH----- 686
            ..|.|.|.|:|...::.               ..|..||||.|:|||||||||:|||...     
Mouse   620 KGLSDCPGELLCEGATDVEKSLPKRRGLHLRGDKTTRVSAAASDESVAGDSGVYEASMKQPGEME 684

  Fly   687 -LPRK-------ELAQVQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSL- 742
             :|..       |.|||||||:|..:....:|.:.:..||.|.  :...:|:||.|.||||:|. 
Mouse   685 DVPYSEEDVTIVETAQVQIGLRYDTKSSSFMVIIAQLRNLHAF--SIPHSSKVYFRVALLPSSAD 747

  Fly   743 --TSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMT-GQKEEIIGTVQISMAE--FN 802
              ...|||.....:..::||.|.|.::...|..|:|:|.:.:.: .::||.:...|||:|:  |:
Mouse   748 VSCLFRTKVHPPTESVLYNDVFRVAVSQAALQQKTLRVDLCSASKHRREECLAGTQISLADLPFS 812

  Fly   803 PEDSTLKWYNVLSSKFI------------------PSFESLDIPSTSA-----AAAAAAVAASNA 844
            .|...| |||:|.||.:                  |..:.:|:.:.||     :|...||....|
Mouse   813 NEIFML-WYNLLPSKQMPCKKNEDGNEEPGARSQQPMLDPIDLDAVSALLARTSAELLAVEQELA 876

  Fly   845 P------------NPGNN-----REESSD-----ESTITSSQTSTLTRNQAPCMELQEQMAAELL 887
            .            .||.:     ||.|.:     ||.:..::.|..|.:..||..          
Mouse   877 QEEEEEELRPERRGPGRDCLTMLREASDEPAALRESGVPLAEGSRCTEDPKPCPR---------- 931

  Fly   888 GLGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSSMLHAYLQNMKQEFADKETNTDR----- 947
              || ...:|.      :|...|..||.|.:..:                 .|||||||.     
Mouse   932 --GP-ETSQCR------KEPAEDPGQLPSGLPTL-----------------VDKETNTDEVVDSN 970

  Fly   948 -AYLPEK----SRGQSQLMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHT-FQ 1006
             |..|:.    |..|...:.:..:.|||||:|.|   :::|.||||||||||:.   :|..: |.
Mouse   971 MAVRPKDRSSLSSRQHPFVRNSVIVRSQTFSPGE---RSQYICRLNRSDSDSST---LAKKSLFV 1029

  Fly  1007 RGAAERRSLRFHSKAPKSVTKLHHTHIP-RTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQK 1070
            |.:.||||||......:...:......| ||||||||||||..::...|||::..|:.|::.|::
Mouse  1030 RNSTERRSLRVKRAVCQPTLRRTAQECPVRTSLDLELDLQASLTRQSRLNDELQALRGLRQKLEE 1094

  Fly  1071 ACENKDPLVAAWAIENEEFQRLVARAD-PAKCPEERQLQ-----KLLMKTAKEIHKLRK--TKVP 1127
            .....:..:....:|:|.||:|:.:|: .|:..:|.|.|     :|:.:.:|::.:||:  .|.|
Mouse  1095 LKAQGETDLPPGVLEDERFQKLLKQAEKQAEQTKEEQKQDLNAERLMRQVSKDVCRLREQSQKEP 1159

  Fly  1128 KGCPDLVSFKEKITFFTRKGLSVPELPSE 1156
            :   .:.||:|||.:|||..:|:|.||::
Mouse  1160 R---QVQSFREKIAYFTRAKISIPSLPAD 1185

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kibraNP_001034055.1 WW 57..87 CDD:238122 16/29 (55%)
WW 103..132 CDD:278809 16/28 (57%)
C2_Kibra 693..813 CDD:176062 43/125 (34%)
Wwc2NP_598552.2 WW 12..41 CDD:278809 15/28 (54%)
WW 59..88 CDD:278809 16/28 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 438..464 11/25 (44%)
C2_Kibra 699..822 CDD:176062 43/125 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 830..849 1/18 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 874..963 24/124 (19%)
Phage_Nu1 <1088..>1146 CDD:294991 13/57 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167847367
Domainoid 1 1.000 257 1.000 Domainoid score I2005
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 531 1.000 Inparanoid score I1201
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG50236
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003726
OrthoInspector 1 1.000 - - otm43845
orthoMCL 1 0.900 - - OOG6_103792
Panther 1 1.100 - - O PTHR14791
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4620
SonicParanoid 1 1.000 - - X1418
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.790

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