DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and HERC5

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_011530324.2	Gene:	HERC5 / 51191	HGNCID:	24368	Length:	1100	Species:	Homo sapiens

Alignment Length:	876	Identity:	163/876 - (18%)
Similarity:	260/876 - (29%)	Gaps:	307/876 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   514 QRLFQQHQQQRLH-----------PVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQT 567
            ||..:.|..|.|.           |.|..|.|..:. ....|..|||::.|  .|.::
Human    12 QRFLESHSVQELRWPLPARGHFLSPAHRPLPQPTTC-CLWPPAKSLSLQFP--FPFRF------- 66

  Fly   568 PQALKEEPTYANAL-PAPPAYTAPPP------------------VPISGVRARP-YDLDSTVLDC 612
             :.||   |..|.: ..|....||||                  ||.....||. :.|      |
Human    67 -RPLK---TTTNIMFRFPLELQAPPPNSTWGAWRPGRGSVAEAAVPRRHAAARSWFPL------C 121

  Fly   613 MMLEAKLQKLNMGTPLNLAVAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDS 677
            ......:..|:.||..:|    |||:...|.  ....|..||..|..|.||.:...:....|...
Human   122 SATPEAVGALSPGTRRSL----LSPLGLGPR--KAAMERRSRRKSRRNGRSTAGKAAATQPAKSP 180

  Fly   678 GV---FEASRAHLPRKELAQVQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLP 739
            |.   ...|.|.|.|..|.:|::..:.....|.|.| |||....:.:....|.:.     .|..|
Human   181 GAQLWLFPSAAGLHRALLRRVEVTRQLCCSPGRLAV-LERGGAGVQVHQLLAGSG-----GARTP 239

  Fly   740 NSLTSIRTKALGDFQKPVFNDTFA----------VPITLDKLLTKSLQVTVVTMTGQKEEIIGTV 794
            ..:      .||...|....|..|          .|...|....|.|:...:.   |:::||
Human   240 KCI------KLGKNMKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHLRFESIL---QEKKII--- 292

  Fly   795 QISMAEF-----NPEDSTLKWYNVLSSKF-----IPSFESLDIPSTSAAAAAAAVAASNAPN--- 846
            ||:..::     :.......|...|..:.     .||..:..|....|....|.::|..|.:
Human   293 QITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMAL 357

  Fly   847 --PGN--------------NREESSDESTIT--------------SSQTSTLTR----------- 870
              .||              ...||.|:.::.              .|.::.||:
Human   358 SMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGK 422

  Fly   871 -----NQAPCMELQEQMAAELLG------------------------------------------ 888
                 :.:...||:..:.|||:|
Human   423 HGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQ 487

  Fly   889 LGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSSML-----HAYLQNMKQEFADKETNTDRA 948
            |.|| ..:.|..::...|....:|:|:...| .|.|.:|     ::|: |:|:........|.:.
Human   488 LMPL-PVKVSSSEELKLESHTSEKELIMIAG-GNQSILLWIKKENSYV-NLKRTIPTLNEGTVKR 549

  Fly   949 YLP--EKSRGQSQLMDDRPVKRSQTFTPSEAFSKNRYN------CRLNRSDSDSAMHCGVAPHTF 1005
            ::.  |..|.||...:.:.:..|..........|.|..      ..||:           |.:.|
Human   550 WIADVETKRWQSTKREIQEIFSSPACLTGSFLRKRRTTEMMPVYLDLNK-----------ARNIF 603

  Fly  1006 QRGAAE---------------RRSLRFHSKAPKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLN 1055
            :....:               .:.|.|||.             |:.:|:           ::||.
Human   604 KELTQKDWITNMITTCLKDNLLKRLPFHSP-------------PQEALE-----------IFFLL 644

  Fly  1056 DQ--IAKLQNLKEVL-----QKACENKDP----LVAAWA-IENEEFQRLVARADPA--------- 1099
            .:  :..:.|..|.|     :..|:..|.    |...|| ::...|.:||.....|
Human   645 PECPMMHISNNWESLVVPFAKVVCKMSDQSSLVLEEYWATLQESTFSKLVQMFKTAVICQLDYWD 709

  Fly  1100 KCPEERQLQKLLMKTAKEIHKLRKTKVPKGCPDLVSFKEKITFFTRKGLSVPELPSEFTLPEA-- 1162
            :..||....:.|::..|::|:.:|.|.                :.|......|..|||.|...
Human   710 ESAEENGNVQALLEMLKKLHRSKKHKA----------------YLRSAAIEEERESEFALRPTFD 758

  Fly  1163 -------------NPIEEEEEEEDENEFYNS 1180
                         |.:.:.|.|:...|.:.|
Human   759 LTVRRNHLIEDVLNQLSQFENEDLRKELWVS 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809
		C2_Kibra	693..813	CDD:176062	25/134 (19%)
HERC5	XP_011530324.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900