Protein Alignment kibra and Magi2

DIOPT Version :10

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_006535806.1
• Gene: Magi2 / 50791
• MGIID: 1354953
• Length: 1414
• Species: Mus musculus
• Alignment Length: 857
• Identity: 172/857 - (20%)
• Similarity: 305/857 - (35%)
• Gaps: 244/857 - (28%)

  Fly    11 SQHHLHPHHLRPQQQQQQHHHHHQQQQQQQHTHHQQQQQHHSDFPLPDGWDIAKDFDGKTYYIDH 75
            ||.:..|.:.:|:          :.:.|...|...:.:::....||||.|::|....|:.|:|||
Mouse   268 SQPYPAPVYSQPE----------ELKDQMDDTKPTKPEENEDSDPLPDNWEMAYTEKGEVYFIDH 322

  Fly    76 INKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDP--RQEWKT 138
            ..|.|:||||| ...|.:..|:|..:|||.|||:..||..|.||::|:.:.||.|:|  ..:.|.
Mouse   323 NTKTTSWLDPR-LAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKL 386

  Fly   139 VQEQMLSDYLSAAQDQLENKRE--MFDVKQQRLLWAQEEYNHLKLAASRSSLCSSSSSMSRHDP- 200
            .|..|....|.|...|....||  :|.....:|     :...|.....:|::....:.:...:|
Mouse   387 QQHNMPHTELGAKPLQAPGFREKPLFTRDASQL-----KGTFLSTTLKKSNMGFGFTIIGGDEPD 446

  Fly   201 ELLRADLML-----ARERVHQLKQELTHITNDI---SYTERGMNTLYS---VGEKINA------- 247
            |.|:...::     |::...:....:.:| |::   .:|...:..|:.   :|:.:|.
Mouse   447 EFLQVKSVIPDGPAAQDGKMETGDVIVYI-NEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYP 510

  Fly   248 ----RENGCYDIAEVHAIREEMLKVHKSLVSG----EKVREELMRSLVQIKNELGRQQIS----E 300
                .|:....:....||.|....|   :|:|    |...|.:.|:...:.:...|...|    .
Mouse   511 LPFDPEDPANSMVPPLAIMERPPPV---MVNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMP 572

  Fly   301 ENSDLASPF------DRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQ--- 356
            .:..|...:      |.|.:||             .||..||:....         |.|..|
Mouse   573 ADGQLDGTYPPPVHDDNVSMAS-------------SGATQAELMTLT---------IVKGAQGFG 615

  Fly   357 -QLADHV--ERIE--------PGQLESDKDRILLIQEKEKLLNDLNSIS----LKS--RSEEEKR 404
             .:||..  :|::        ||..|.|    |:::..::.:.:|:...    ||.  ...|...
Mouse   616 FTIADSPTGQRVKQILDIQGCPGLCEGD----LIVEINQQNVQNLSHTEVVDILKDCPVGSETSL 676

  Fly   405 VIHQ----TRHKLEEDLKEAYEANNT--------CVANRLRF----------------------- 434
            :||:    :..|..:.:.:.:|...:        .|...|.|
Mouse   677 IIHRGGFFSPWKTPKPMMDRWENQGSPQTSLSAPAVPQNLPFPPALHRSSFPDSTEAFDPRKPDP 741

  Fly   435 ---HEEKQLLLDKLQEALKST-----------KLLEERLKSFSSESTFSISSGSSLGSLSTASSK 485
               :|:.:.:.:..|:....|           |.|:..|:...|...|.|..|...|......:.
Mouse   742 YELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAV 806

  Fly   486 SALSFTD-----------IYID--PFAVDSPIDVVDLRRRSQRLFQQHQQQRLHPVHPVLQQQQS 537
            .|:...|           :|:|  |.|..:...|:||...:.|                     :
Mouse   807 IAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAAR---------------------N 850

  Fly   538 AEVTLSPRSSLSMETPPASPMKYNAGADQT----PQALKEEPTYANALPAPPAYTAPPP------ 592
            .:|.|:.|..:.....|......:.|:..|    |::  :..||:|:..|.|:..|.||
Mouse   851 GQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRS--DYATYSNSNHAAPSSNASPPEGFASH 913

  Fly   593 -------------------VPISGVRARPYD-------------LDSTVLD-CMMLEA--KLQKL 622
                               |.||.:. ||..             :|.:..| |..|:.  ::..:
Mouse   914 SLQTSDVVIHRKENEGFGFVIISSLN-RPESGATITVPHKIGRIIDGSPADRCAKLKVGDRILAV 977

  Fly   623 NMGTPLNLAVAPLSPISE----KPSLLDLPQEML-SRSSSTSNTRSVSAAVSNESVAGDSGVFEA 682
            |..:.:|:..|.:..:.:    ..:|..:|||.| |.:|:.|:.:....|..:..:|..|.:.:.
Mouse   978 NGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQHSPLAQQSPLAQP 1042

  Fly   683 SRAHLPRKELAQ 694
            |.| .|...:||
Mouse  1043 SPA-TPNSPVAQ 1053

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	15/29 (52%)
		WW	103..132	CDD:459800	14/28 (50%)
		C2_Kibra	693..813	CDD:176062	2/2 (100%)
Magi2	XP_006535806.1	PDZ0_MAGI-1_3-like	14..99	CDD:467212
		NK	118..290	CDD:450170	5/31 (16%)
		WW	304..334	CDD:238122	16/30 (53%)
		WW	349..380	CDD:197736	15/30 (50%)
		PDZ1_MAGI-1_3-like	423..507	CDD:467213	12/84 (14%)
		PDZ2_MAGI-1_3-like	600..681	CDD:467214	19/93 (20%)
		PDZ3_MAGI-1_3-like	775..859	CDD:467215	19/104 (18%)
		PDZ4_MAGI-1_3-like	919..1007	CDD:467216	13/88 (15%)
		PDZ5_MAGI-1_3-like	1137..1219	CDD:467217
		PHA03307	<1255..>1407	CDD:223039