DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and Magi1

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_038964101.1	Gene:	Magi1 / 500261	RGDID:	1586025	Length:	1491	Species:	Rattus norvegicus

Alignment Length:	1304	Identity:	260/1304 - (19%)
Similarity:	427/1304 - (32%)	Gaps:	387/1304 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 PLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQ-TFEDCVGD-------------ELPM 105
            |||:.|::|...:|:.|:|||..|.|:||||| |..|.| ..|:|..|             |||.
  Rat   301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPR-CLNKQQKPLEECEDDEEGVHTEELDSELELPA 364

  Fly   106 GWEESYDPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLL 170
            |||:..||..|.||::|:.:.||.|:|..|.|..::      |...|.|.:::::    .||...
  Rat   365 GWEKIEDPVYGVYYVDHINRKTQYENPVLEAKRKRQ------LEQQQQQQQHQQQ----PQQPQP 419

  Fly   171 WAQEEY--NHLKLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTH---------I 224
            ...||:  :|    ||.....:.|...|..:|         |||...|.|...|.         |
  Rat   420 PQPEEWTEDH----ASVVPPVAPSHPPSNPEP---------AREAPLQGKPFFTRNPSELKGKFI 471

  Fly   225 TNDISYTERG---------------------------MNTLYSVGEKINARENGCYDIAEVHAIR 262
            ...:..:.||                           ::.....|:.|.:..:.|. :...||
  Rat   472 HTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV-LGHTHA-- 533

  Fly   263 EEMLKVHKSLVSGEKVREELMR-------------SLVQIKNELGRQQI---SEEN--------- 302
             :::|:.:|:..|..|..||.|             |||.....|.::.|   .:|.
  Rat   534 -QVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSS 597

  Fly   303 ----------------SDLAS------PFDRVCVAS----QTDLC------GSSGENL------- 328
                            :|:||      |.|.|.:||    |.:|.      |..|...
  Rat   598 KTGKVSNMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPG 662

  Fly   329 NGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSI 393
            .||.|..::.                                  |..|...::|.:.::
  Rat   663 GGGQRVKQIV----------------------------------DSPRCRGLKEGDLIV------ 687

  Fly   394 SLKSRSEEEKRVIHQTRHKLEED-LKEAYEANNTCVANRLRFHEEKQLLLDK--LQEALKSTKLL 455
                  |..||.:....|....| |.|..:.:            |..||:.:  |....||.|..
  Rat   688 ------EVNKRNVQALTHNQVVDMLIECPKGS------------EVTLLVQRGGLPVPKKSPKSQ 734

  Fly   456 EERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQH 520
            ....|...:.|..|:   |||.||.|||...:......| .|..|.:|.......::....|:..
  Rat   735 PLERKDSQNSSQHSV---SSLRSLHTASPSHSAQVLPEY-PPADVPAPDQTDSSGQKKPDPFKIW 795

  Fly   521 QQQRLHPVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTPQ-------ALKEEPTYA 578
            .|.|        ...::..::.||.|.||...........|.|..|.|.       ..::|..:.
  Rat   796 AQSR--------SMYENRPMSPSPASGLSKGERDREINSTNFGECQIPDYQEQDIFLWRKETGFG 852

  Fly   579 NAL-----PAPPAYTAPPPVPISGV----RARPYD----LDST---------VLDCMMLEAKLQK 621
            ..:     |..|.|.. ..||:...    |.|..|    :|.|         |:..|...||...
  Rat   853 FRILGGNEPGEPIYIG-HIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGH 916

  Fly   622 LNMGTPLNLAVAPLSPISEKPS----------LLDLPQEMLSRSSSTSNTRSVSAAVSNES---- 672
            :|:.....:........:|.||          ...|.:|..:...|.::..:||:...:.|
  Rat   917 VNLTVRRKVVFTVPKAENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGS 981

  Fly   673 -VAGDSGVFEASRAHLPRKELAQVQIGLKYLKQEG---VLVVSLERANNLLALWTASADNSQVYL 733
             ..|.|||..|        .|....:.::..:.||   |:|.|:.|..    ..|..|.|:.|
  Rat   982 GGGGGSGVVSA--------VLQPYDVEIRRGENEGFGFVIVSSVSRPE----AGTTFAGNACV-- 1032

  Fly   734 RAALLPNSLTSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMTGQK-EEIIGTVQIS 797
               .:|:.:..|...:..|....:            |:..:.|.|...::|.:. .:|:..::
  Rat  1033 ---AMPHKIGRIIEGSPADRCGKL------------KVGDRILAVNGCSITNKSHSDIVNLIK-- 1080

  Fly   798 MAEFNPEDSTLKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITS 862
                       :..|.::.:.||..||.:....:.|...|.:..::||    :::.:.:..|.|.
  Rat  1081 -----------EAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHAP----SQQGTQETRTTTK 1130

  Fly   863 SQTSTLTRNQAPCMELQEQ--------MAAELLGLGPLNEPECSDD------DDDDEEEELDDKQ 913
            .:..:....:.| ...|||        ..|:..|.......|.:.|      .:|...|.....:
  Rat  1131 PKPDSQFEFKGP-QATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMR 1194

  Fly   914 LVSDVGLMNSSSMLHAYLQNMKQ----EFADKETNTDRAYLPEKSRGQSQLMDDRPVKRSQTFTP 974
            :..::..:|..:     .:|||.    |.........|.:|   .||...:.:..|  .|....|
  Rat  1195 IGDEILEINGET-----TKNMKHSRAIELIKNGGRRVRLFL---RRGDGSVPEYDP--SSDRNGP 1249

  Fly   975 SEAFSKNRYNCRLNRSD--SDSAMHCGVAPHTFQRGA-AERRSLRFHSKAPKSVTKLHHTHIPRT 1036
            |.. ::.....||...|  |..|:.....|...:... ||:|:   |:|.||.    :..|
  Rat  1250 STG-AQGVPEVRLGPPDHRSHPALESSYPPDLHKSSQHAEKRA---HAKDPKG----NREH---- 1302

  Fly  1037 SLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACENKDPLVAAWAIENEEFQRLVARADPAKC 1101
                    ..|.::.:..|....|..:      .||..||.....|.....|:  ........:.
  Rat  1303 --------SGQPNEHHTWNGTSRKPDS------GACRPKDRPPDTWREAQPEW--TATNGPKRRS 1351

  Fly  1102 PEERQ---------LQKLLMKTAKEIHKLRKTKVPKGCPDLVSFKEKITFFTRKGLSVPELPSEF 1157
            ||:|:         |::      :|.|:.|:...|:...:....:.|.:..:|:..|:..|..:.
  Rat  1352 PEKRREGTRSADNTLER------REKHEKRREMSPERKRERSPTRRKDSSPSRRRRSLERLLDQR 1410

  Fly  1158 TLPE 1161
            ..||
  Rat  1411 RSPE 1414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	14/29 (48%)
		WW	103..132	CDD:278809	14/28 (50%)
		C2_Kibra	693..813	CDD:176062	18/123 (15%)
Magi1	XP_038964101.1	NK	122..293	CDD:418433
		WW	302..331	CDD:395320	13/28 (46%)
		WW	362..393	CDD:197736	15/30 (50%)
		PDZ	469..555	CDD:214570	14/89 (16%)
		PDZ	640..723	CDD:214570	19/140 (14%)
		MAGI_u5	724..806	CDD:406953	22/93 (24%)
		PDZ_signaling	847..922	CDD:238492	16/75 (21%)
		PDZ_signaling	996..1091	CDD:238492	19/128 (15%)
		PDZ	1152..1234	CDD:214570	14/89 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I11983
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900