DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kibra and Wwc2

DIOPT Version :9

Sequence 1:NP_001034055.1 Gene:kibra / 41783 FlyBaseID:FBgn0262127 Length:1288 Species:Drosophila melanogaster
Sequence 2:NP_001102581.1 Gene:Wwc2 / 498630 RGDID:1559427 Length:1194 Species:Rattus norvegicus


Alignment Length:1252 Identity:388/1252 - (30%)
Similarity:617/1252 - (49%) Gaps:220/1252 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 PLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYY 119
            |||.||:.|:|:|||.:||||..::|:|:||||..|||.:|.||||||||.|||..:||.||.||
  Rat    11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQIGAYY 75

  Fly   120 INHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHL----- 179
            |:|:.::||:||||::|:..||:||.||||.|||.|..::|::.||:|||..|.:||..|     
  Rat    76 IDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQRLALALDEYVRLNDAYK 140

  Fly   180 KLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSVGEK 244
            :.::|.:||.|.|||.:::||::|:|::...|.||.:||:||:.:..::.|.::|..||..:.||
  Rat   141 EKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQELLYKQQGFETLQQIDEK 205

  Fly   245 INARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQ----------IS 299
            ::..::| |:::|..||..|:..:.|::.||||.:::||:||.:::......|          .|
  Rat   206 MSGGQSG-YELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERFHLDQNMGSSEPDLRCS 269

  Fly   300 EENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVER 364
            ..||.|:.....:...|||.:.|..|  :...:..||..:...||.|.::.:..|:.:|:.....
  Rat   270 PVNSHLSLSRQTLDAGSQTSISGDIG--VRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLDGE 332

  Fly   365 IEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVA 429
            ..||.|:.:|::::||.|||:||.:|..|:.:.|:::|...:...|.:|||:|..|....:..:|
  Rat   333 AWPGALDVEKEKLMLINEKEELLKELQFITPQKRTQDELERLEAERQRLEEELVAARGLPSRALA 397

  Fly   430 NRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSL---------STASSK 485
            .||:..|:::.||.||:|..|.|..|..:|||.|| ||.|:|||||||||         |:..|.
  Rat   398 ERLKLEEKRKELLQKLEETTKLTTYLYSQLKSLSS-STLSMSSGSSLGSLASSRGSLNTSSRGSL 461

  Fly   486 SALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQHQQQRLHP------VH--------------- 529
            ::||.:|:|     ..|..|.:|...:.:..|...::....|      :|               
  Rat   462 NSLSSSDLY-----YSSQGDQMDTDYQYKLDFLLQEKGGYIPSGPITTIHENEVVKSPSQPGQSG 521

  Fly   530 ------------PVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALP 582
                        |.|.:...:..:||.|||||..:||.||:.    .|.|               
  Rat   522 LCGLGVAATSHTPPLTEASKSVTSLSSRSSLSSLSPPGSPLV----LDST--------------- 567

  Fly   583 APPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAV------APLSPISEK 641
                      .|.|.....|:...:.:.||   |......::|...|..:      .|...:.|.
  Rat   568 ----------FPGSSHDTSPHQFTADLEDC---ELSRHFADIGLGENQVLLDSDSGGPSQSLLED 619

  Fly   642 PSLLDLPQEMLSRSSST---------------SNTRSVSAAVSNESVAGDSGVFEASRAH----- 686
            ..|.:....:|...|:.               ..|..||||.|:|||||||||:|||...     
  Rat   620 KDLDECTGGLLYEGSADVEKSLPKRRGLHLRGDKTARVSAAASDESVAGDSGVYEASVKQPGEIE 684

  Fly   687 -LPRK-------ELAQVQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSL- 742
             :|.:       |.|||||||:|..:....:|.:.:..||.|.  :...:|:||.|.|:||:|. 
  Rat   685 DIPYREEDVTIVETAQVQIGLRYDTKSSSFMVIIAQLRNLHAF--SIPHSSKVYFRVAVLPSSAD 747

  Fly   743 --TSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMT-GQKEEIIGTVQISMAE--FN 802
              ...|||.....:..::||.|.|.|:...|..|:|:|.:.::: .::||.:...|||:|:  |:
  Rat   748 VSCLFRTKVHPPTESVLYNDVFRVAISQVVLQQKTLRVDLCSVSKRRREECLAGTQISLADLPFS 812

  Fly   803 PEDSTLKWYNVLSSKFI------------------PSFESLDIPSTSAAAAAAAVAASNAPNPGN 849
            .|...| |||:|.||.|                  |:.:|.|:.:.||..|..:...........
  Rat   813 NEIFML-WYNLLPSKQIPCKKKEEGGGQPGAQSPQPALDSADLDAVSALLARTSAELLAVEQELA 876

  Fly   850 NREESSDESTITSSQTSTLTRNQAP---CMELQEQMAAELL------------GLGPLNEPECSD 899
            ..||..:|..:.       ..::.|   |:.:..:.:||.:            |..|.:...|:.
  Rat   877 QEEEEEEEEELR-------PEHRGPGEDCLTMLREASAETVAAKESGVHLAEGGHCPEDPSPCTR 934

  Fly   900 DDDDDEEEELDDKQLVSDVGLMNSSSMLHAYLQNMKQEFADKETNTDRAY---LPEKSRGQSQLM 961
            ......::...:|....|.|...::          .....|||||||.|.   :..:.:.:|.|.
  Rat   935 GPGTSRDQCRKEKGRTEDPGQPATA----------VPTLVDKETNTDEAVDSNIAVRPKDRSSLS 989

  Fly   962 DDR-------PVKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHT-FQRGAAERRSLRFH 1018
            ...       .:.|||||:|.|   :::|.||||||||||:.   :|..: |.|.:.||||||..
  Rat   990 SQHHPFVRSSVIVRSQTFSPGE---RSQYICRLNRSDSDSST---LAKKSLFVRNSTERRSLRVK 1048

  Fly  1019 SKAPKSVTKLHHTHIP-RTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACENKDPLVAAW 1082
            ....:...:......| ||||||||||||..::...|||::..|:.|::.|::.....:..:...
  Rat  1049 RAVCQPTLRRTAQECPVRTSLDLELDLQASLTRQSRLNDELQALRGLQQKLEELKAQGETDLPPG 1113

  Fly  1083 AIENEEFQRLVARAD-PAKCPEERQLQ-----KLLMKTAKEIHKLRK--TKVPKGCPDLVSFKEK 1139
            .:.:|.||:|:.:|: .|:..:|.|.|     :|:.:.:|::.:||:  .|.|:   .:.||:||
  Rat  1114 MLGDERFQKLLKQAEKQAEQTKEEQKQDLNAERLMRQVSKDVCRLREQSQKEPR---QVQSFREK 1175

  Fly  1140 ITFFTRKGLSVPELPSE 1156
            |.:|||..:|:|.||::
  Rat  1176 IAYFTRAKISIPSLPAD 1192

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kibraNP_001034055.1 WW 57..87 CDD:238122 16/29 (55%)
WW 103..132 CDD:278809 16/28 (57%)
C2_Kibra 693..813 CDD:176062 43/125 (34%)
Wwc2NP_001102581.1 WW 12..41 CDD:278809 15/28 (54%)
WW 59..88 CDD:278809 16/28 (57%)
DUF342 <283..385 CDD:302792 31/103 (30%)
YlqD 351..>420 CDD:287979 24/68 (35%)
C2_Kibra 699..822 CDD:176062 43/125 (34%)
Phage_Nu1 <1095..>1153 CDD:294991 12/57 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166350921
Domainoid 1 1.000 258 1.000 Domainoid score I1933
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 538 1.000 Inparanoid score I1149
OMA 1 1.010 - - QHG50236
OrthoDB 1 1.010 - - D181722at33208
OrthoFinder 1 1.000 - - FOG0003726
OrthoInspector 1 1.000 - - otm45932
orthoMCL 1 0.900 - - OOG6_103792
Panther 1 1.100 - - O PTHR14791
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1418
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.770

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