Protein Alignment kibra and Wwc2

DIOPT Version :10

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001102581.1
• Gene: Wwc2 / 498630
• RGDID: 1559427
• Length: 1194
• Species: Rattus norvegicus
• Alignment Length: 1252
• Identity: 388/1252 - (30%)
• Similarity: 619/1252 - (49%)
• Gaps: 220/1252 - (17%)

  Fly    55 PLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYY 119
            |||.||:.|:|:|||.:||||..::|:|:||||..|||.:|.||||||||.|||..:||.||.||
  Rat    11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQIGAYY 75

  Fly   120 INHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHL----- 179
            |:|:.::||:||||::|:..||:||.||||.|||.|..::|::.||:|||..|.:||..|
  Rat    76 IDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQRLALALDEYVRLNDAYK 140

  Fly   180 KLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSVGEK 244
            :.::|.:||.|.|||.:::||::|:|::...|.||.:||:||:.:..::.|.::|..||..:.||
  Rat   141 EKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQELLYKQQGFETLQQIDEK 205

  Fly   245 INARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQ----------IS 299
            ::..::| |:::|..||..|:..:.|::.||||.:::||:||.:::......|          .|
  Rat   206 MSGGQSG-YELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERFHLDQNMGSSEPDLRCS 269

  Fly   300 EENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVER 364
            ..||.|:.....:...|||.:.|..|  :...:..||..:...||.|.::.:..|:.:|:.....
  Rat   270 PVNSHLSLSRQTLDAGSQTSISGDIG--VRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLDGE 332

  Fly   365 IEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVA 429
            ..||.|:.:|::::||.|||:||.:|..|:.:.|:::|...:...|.:|||:|..|....:..:|
  Rat   333 AWPGALDVEKEKLMLINEKEELLKELQFITPQKRTQDELERLEAERQRLEEELVAARGLPSRALA 397

  Fly   430 NRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSL---------STASSK 485
            .||:..|:::.||.||:|..|.|..|..:|||.|| ||.|:|||||||||         |:..|.
  Rat   398 ERLKLEEKRKELLQKLEETTKLTTYLYSQLKSLSS-STLSMSSGSSLGSLASSRGSLNTSSRGSL 461

  Fly   486 SALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQ-------------HQQQRL------------ 525
            ::||.:|:|..  :....:| .|.:.:...|.|:             |:.:.:
  Rat   462 NSLSSSDLYYS--SQGDQMD-TDYQYKLDFLLQEKGGYIPSGPITTIHENEVVKSPSQPGQSGLC 523

  Fly   526 --------HPVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALP 582
                    |.  |.|.:...:..:||.|||||..:||.||:.    .|.|
  Rat   524 GLGVAATSHT--PPLTEASKSVTSLSSRSSLSSLSPPGSPLV----LDST--------------- 567

  Fly   583 APPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAV------APLSPISEK 641
                      .|.|.....|:...:.:.||   |......::|...|..:      .|...:.|.
  Rat   568 ----------FPGSSHDTSPHQFTADLEDC---ELSRHFADIGLGENQVLLDSDSGGPSQSLLED 619

  Fly   642 PSLLDLPQEMLSRSSST---------------SNTRSVSAAVSNESVAGDSGVFEASRAH----- 686
            ..|.:....:|...|:.               ..|..||||.|:|||||||||:|||...
  Rat   620 KDLDECTGGLLYEGSADVEKSLPKRRGLHLRGDKTARVSAAASDESVAGDSGVYEASVKQPGEIE 684

  Fly   687 -LPRK-------ELAQVQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSL- 742
             :|.:       |.|||||||:|..:....:|.:.:..||.|.  :...:|:||.|.|:||:|.
  Rat   685 DIPYREEDVTIVETAQVQIGLRYDTKSSSFMVIIAQLRNLHAF--SIPHSSKVYFRVAVLPSSAD 747

  Fly   743 --TSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMT-GQKEEIIGTVQISMAE--FN 802
              ...|||.....:..::||.|.|.|:...|..|:|:|.:.::: .::||.:...|||:|:  |:
  Rat   748 VSCLFRTKVHPPTESVLYNDVFRVAISQVVLQQKTLRVDLCSVSKRRREECLAGTQISLADLPFS 812

  Fly   803 PEDSTLKWYNVLSSKFI------------------PSFESLDIPSTSAAAAAAAVAASNAPNPGN 849
            .|...| |||:|.||.|                  |:.:|.|:.:.||..|..:...........
  Rat   813 NEIFML-WYNLLPSKQIPCKKKEEGGGQPGAQSPQPALDSADLDAVSALLARTSAELLAVEQELA 876

  Fly   850 NREESSDESTITSSQTSTLTRNQAP---CMELQEQMAAELL------------GLGPLNEPECSD 899
            ..||..:|..:.       ..::.|   |:.:..:.:||.:            |..|.:...|:.
  Rat   877 QEEEEEEEEELR-------PEHRGPGEDCLTMLREASAETVAAKESGVHLAEGGHCPEDPSPCTR 934

  Fly   900 DDDDDEEEELDDKQLVSDVGLMNSSSMLHAYLQNMKQEFADKETNTDRAY---LPEKSRGQSQLM 961
            ......::...:|....|.|...::          .....|||||||.|.   :..:.:.:|.|.
  Rat   935 GPGTSRDQCRKEKGRTEDPGQPATA----------VPTLVDKETNTDEAVDSNIAVRPKDRSSLS 989

  Fly   962 DDR-------PVKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHT-FQRGAAERRSLRFH 1018
            ...       .:.|||||:|.|   :::|.||||||||||:.   :|..: |.|.:.||||||..
  Rat   990 SQHHPFVRSSVIVRSQTFSPGE---RSQYICRLNRSDSDSST---LAKKSLFVRNSTERRSLRVK 1048

  Fly  1019 SKAPKSVTKLHHTHIP-RTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACENKDPLVAAW 1082
            ....:...:......| ||||||||||||..::...|||::..|:.|::.|::.....:..:...
  Rat  1049 RAVCQPTLRRTAQECPVRTSLDLELDLQASLTRQSRLNDELQALRGLQQKLEELKAQGETDLPPG 1113

  Fly  1083 AIENEEFQRLVARAD-PAKCPEERQLQ-----KLLMKTAKEIHKLRK--TKVPKGCPDLVSFKEK 1139
            .:.:|.||:|:.:|: .|:..:|.|.|     :|:.:.:|::.:||:  .|.|:   .:.||:||
  Rat  1114 MLGDERFQKLLKQAEKQAEQTKEEQKQDLNAERLMRQVSKDVCRLREQSQKEPR---QVQSFREK 1175

  Fly  1140 ITFFTRKGLSVPELPSE 1156
            |.:|||..:|:|.||::
  Rat  1176 IAYFTRAKISIPSLPAD 1192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	16/29 (55%)
		WW	103..132	CDD:459800	16/28 (57%)
		C2_Kibra	693..813	CDD:176062	43/125 (34%)
Wwc2	NP_001102581.1	WW	12..41	CDD:459800	15/28 (54%)
		WW	59..88	CDD:459800	16/28 (57%)
		SMC_prok_B	<162..>418	CDD:274008	77/258 (30%)
		C2_Kibra	699..822	CDD:176062	43/125 (34%)
		ATP-synt_Fo_b	<1081..1168	CDD:473877	21/89 (24%)