Protein Alignment kibra and wwc2

DIOPT Version :9

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001004872.1
• Gene: wwc2 / 448191
• XenbaseID: XB-GENE-1001637
• Length: 1171
• Species: Xenopus tropicalis
• Alignment Length: 1262
• Identity: 407/1262 - (32%)
• Similarity: 632/1262 - (50%)
• Gaps: 254/1262 - (20%)

  Fly    51 HSDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNI 115
            :...||||||:.|:|:|||.:||||.:::|:|:||||..|||.:|.||||:|||.|||.||||.|
 Frog     6 NGQLPLPDGWEEARDYDGKVFYIDHNSRQTSWIDPRDRLTKPLSFADCVGNELPWGWESSYDPQI 70

  Fly   116 GPYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHL- 179
            |.|:|||:.|:||:||||:.|:..||:||.|||..|||.|..::|::.:|:|||..|.:||..|
 Frog    71 GVYFINHINQTTQIEDPRKLWRNEQERMLKDYLMVAQDALSTQKELYHIKEQRLALALDEYVRLN 135

  Fly   180 ----KLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYS 240
                :.::||:||.|.|||.:::||::|:|::...:.||.:||:||:.:..::.|.|:|..||..
 Frog   136 DAYKEKSSSRTSLFSGSSSSTKYDPDILKAEISTTKVRVKKLKRELSQMKQELLYKEQGFETLQR 200

  Fly   241 VGEKINARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKNEL------GRQQ-- 297
            :.:|::..::| |::.|...|..|:..:.|::.:|||.:::||:|||::|...      ||.:
 Frog   201 IDQKMSGGQSG-YELREAKDILSELKSIRKAISTGEKEKQDLMQSLVKLKERFHLEEARGRSEPD 264

  Fly   298 --ISEENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLAD 360
              .:..||.|:.....:...||||:.|..|  :...:..||..:...||.|.::.:..|:.:||.
 Frog   265 LRSNLANSHLSLSRQTLDAGSQTDISGDIG--VRSRSNLAEKVRLSLQYEEAKRSMANLKIELAK 327

  Fly   361 HVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANN 425
            ......||.|:.:|::::||.|||:||.:|..::.:.|::.|...:...|.:|||:|.....:.:
 Frog   328 LDSEAWPGALDVEKEKLMLINEKEELLKELQFVTTRRRTQGEIERLEGERRRLEEELLSVKSSPS 392

  Fly   426 TCVANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSL---------ST 481
            ..:|.:|:..|:|:.|:.||:|..||...|..:|||.|: ||.|:|||||:|||         |:
 Frog   393 KALAEQLKIQEKKKELVKKLEEVTKSATYLHSQLKSLSA-STLSVSSGSSIGSLASSRGSLNTSS 456

  Fly   482 ASSKSALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQ-------------HQQQRLHPVH---- 529
            ..|.::||.||:|   :..:.|...:|.:.:...|.|:             |:.:.:| .|
 Frog   457 RGSLNSLSSTDLY---YNQNEPAADLDYQYKLDFLLQEKSGYIPCGPITTIHENEVVH-CHERID 517

  Fly   530 ----PVLQQQ-QSAE-----VTLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALPAP 584
                |..||. |.|:     .:||..||||..:||.|
 Frog   518 YTNSPTAQQDTQDAKPPKSVTSLSSLSSLSSLSPPGS---------------------------- 554

  Fly   585 PAYTAPPPVPISGVRARPYDL---DS--TVLDCMMLEAKLQKLNMGTPLNL--AVAPLS-PISEK 641
                  ||| :.||    :.|   ||  |..:...|......:|:...|.|  :||..| .::|:
 Frog   555 ------PPV-LEGV----FSLCTQDSLRTGFEISELPESFADMNLHENLQLMESVAGESQALAER 608

  Fly   642 PSLLDLPQEMLSRSSSTS--------------------NTRSVSAAVSNESVAGDSGVFEASRAH 686
            .|    ..|.|...||.|                    ....||||||:|||||||||:|.| ..
 Frog   609 KS----TGEGLRHQSSASQEGRTDIEFPRKNPDRVQEEKAMCVSAAVSDESVAGDSGVYEPS-VK 668

  Fly   687 LPRKE-----------LAQVQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPN 740
            .|.::           .||.|:.|:|.......|:.:.:|.|.|:.   ....|::|.|.|:||:
 Frog   669 PPGEDPVFNDDYSILGAAQAQLILRYDSGNSSFVIIIVKARNNLSY---VQFGSRIYFRVAVLPS 730

  Fly   741 SLTS---IRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTM-TGQKEEIIGTVQISMAEF 801
            |..:   .|||.....:..:||:.|.|.|:...|..|:|:|.:.:: ...:|:.:...|||:|:|
 Frog   731 SNDTSCLFRTKVYPATESVLFNELFRVSISQTTLQQKTLRVDMCSVGKTHREDCLAGTQISLADF 795

  Fly   802 N-PEDSTLKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQT 865
            : ..|...:||.:|.|:.||.                             .:|..::|.:::|.|
 Frog   796 SFSNDVHTQWYTLLPSRTIPL-----------------------------HKEQLEKSVLSASNT 831

  Fly   866 STLTRNQAPCMELQEQMAAELLGLGPLNEPECSDDDDDDEE-------------------EELDD 911
            .|...:......|.|:.:|||..:    |.|.:.:|||.|:                   ||.:.
 Frog   832 QTAALDLDAVSALLERTSAELEAV----EQELAQEDDDQEQLCPGDDWPEMAPEESFSTLEEHEA 892

  Fly   912 KQLVSD----VGLMNSS-----------------SMLHAYLQNMKQEFADKETNTDRAYLPE--- 952
            ..|:|.    |.|..||                 |::....|.......||||||:.| |.|
 Frog   893 DLLLSGEYYAVPLQLSSETTEKSEELYGETSNWDSVVSPLPQAELPTLVDKETNTEEA-LQENLS 956

  Fly   953 ---KSRG-----QSQLMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHTFQRGA 1009
               |.|.     |...:.:..:.|||||:|.|   ||:|.||||||||||:.....:|  |.|.|
 Frog   957 VRPKERANLGSRQRPFVRNSMIVRSQTFSPGE---KNQYICRLNRSDSDSSTLAKKSP--FIRNA 1016

  Fly  1010 AERRSLRFHSKAPKSVTK--LHHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKAC 1072
            .||||||......:.:|:  :|... .||||||||||||..::...|||::..|::||:.|::..
 Frog  1017 NERRSLRVKRPICQPMTRRTVHECR-ERTSLDLELDLQASLTRQSRLNDELQSLRDLKQRLEEMK 1080

  Fly  1073 ENKDPLVAAWAIENEEFQRLVARAD-PAKCPEERQLQ-----KLLMKTAKEIHKLRK--TKVPKG 1129
            ...:..:....:|:|.||||:.:|: .|:..:|.|.|     ||:.|.:|::.:||:  .|||.
 Frog  1081 ARGETELPTCVLEDERFQRLLKQAEKQAEQSKEEQKQGLNAEKLMRKASKDVCRLREQSQKVPL- 1144

  Fly  1130 CPDLVSFKEKITFFTRKGLSVPELPSE 1156
              .:.||:||||:|||..:|:|.|.::
 Frog  1145 --QVQSFREKITYFTRAKISIPSLSAD 1169

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	17/29 (59%)
		WW	103..132	CDD:278809	19/28 (68%)
		C2_Kibra	693..813	CDD:176062	37/124 (30%)
wwc2	NP_001004872.1	WW	11..40	CDD:278809	16/28 (57%)
		WW	58..87	CDD:278809	19/28 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..552		11/30 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	603..637		7/37 (19%)
		C2_Kibra	686..808	CDD:176062	37/124 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	232	1.000	Domainoid score	I2362
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	501	1.000	Inparanoid score	I1326
OMA	1	1.010	-	-		QHG50236
OrthoDB	1	1.010	-	-		D181722at33208
OrthoFinder	1	1.000	-	-		FOG0003726
OrthoInspector	1	1.000	-	-		otm49020
Panther	1	1.100	-	-	O	PTHR14791
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080