DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kibra and CG5087

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster

Alignment Length:	241	Identity:	51/241 - (21%)
Similarity:	90/241 - (37%)	Gaps:	50/241 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 SYDPNIG-PYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQD-QLENKREMFDVKQQRLLWA 172
            |..||.| ..|:..|...|.|:.|:.....:....::.|::...: ::..::..|.:....||
  Fly   511 SLGPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLNDYVLL-- 573

  Fly   173 QEEY--NHLKLAASRSSLCSSSSSMSRHDPELLRADLMLARER----------VHQLKQELTHIT 225
              .|  |::.......:|.:.:.::.:|...|....|||...|          .|.|..|:...|
  Fly   574 --TYFLNNILYKLINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLIPEVKPST 636

  Fly   226 --NDISYTERGMNTLYSVGEKINARENGCYDIAEV-HAI-REEMLKVHKSLVSGEKVREELMRS- 285
              ||:              ||  |:.|....:|:: |.| .|:.:|:.:..|..||....|..|
  Fly   637 FINDL--------------EK--AKRNAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESA 685

  Fly   286 -------LVQIKN----ELGRQQISEENSDLASPFDRVCVASQTDL 320
                   |:.|..    |.|.:|::.:.:.......||...:|..|
  Fly   686 CASPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGL 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809	8/22 (36%)
		C2_Kibra	693..813	CDD:176062
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	8/38 (21%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	4/14 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900