Protein Alignment kibra and Smurf

DIOPT Version :10

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_523779.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Alignment Length: 574
• Identity: 118/574 - (20%)
• Similarity: 189/574 - (32%)
• Gaps: 176/574 - (30%)

  Fly    18 HHLRPQQQQQQHHHHHQQQQQQQHTHHQQQQ---QH---HSDFPLPDGWDIAKDFDGKTYYIDHI 76
            :.:|..||.|.:.:|........|.....:.   ||   .:..|||.||:..|...|:.|::||.
  Fly   519 YEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTLDAIGPLPSGWEQRKTASGRVYFVDHN 583

  Fly    77 NKKTTWLDPR---------DCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQ------- 125
            |:.|.:.|||         ...|.|.|.....|...|        |:..|...:..|.
  Fly   584 NRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAP--------PSATPATPSAAAAVPPQATP 640

  Fly   126 ---------STQLEDPRQEWKTVQEQML--SDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHL 179
                     :|....|.:....:.:.:|  :|.|...:..|..|......:.|.:   |.:..|.
  Fly   641 ASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQTM---QPQSGHC 702

  Fly   180 KLAASRSSLCSSS----SSMSRHDPELLRADLM-------------LARERVHQLKQE------- 220
            :|..||:.:...|    ..|...|   :|..||             :|||.:|.|.:|
  Fly   703 RLEVSRNEIFEESYRLIMKMRAKD---MRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYG 764

  Fly   221 LTHITNDISYT-----ERGMNT-----LYSVGEKINAR--ENGCYDIAEVHAIREEMLKVHKSLV 273
            |...:.|..||     :.|:|.     .:.||..:...  ...|.|........:::|....:|.
  Fly   765 LFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLG 829

  Fly   274 SGEKVREELMRSLVQI--KNELG--RQQISEENSDLASPFDRVCVASQTDLCGSSGENLNGGARF 334
            ..|.|..:|.|||..:  .|..|  ....|.||:.    |..:.|          .|...|||..
  Fly   830 DIEGVDPDLHRSLTWMLESNISGIIESTFSVENNS----FGALVV----------HELKPGGASI 880

  Fly   335 AEMAKTKWQYAEW---RKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKL---------- 386
            ....:.|.:|.:.   .:.::.::||..    .::.|..|.....:|...::.:|
  Fly   881 PVTEENKREYVKLYVNYRFMRGIEQQFL----ALQKGFCELIPSHLLRPFDERELELVIGGISSI 941

  Fly   387 -LND-LNSISLKSRSEEEKRV-------------------------------------------- 405
             :|| .|:..||..:.|..:|
  Fly   942 DVNDWRNNTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVG 1006

  Fly   406 -----IHQTRHKLEEDLKEAYEANNTCVANRLRF--HEEKQLLLDKLQEALKST 452
                 ||.|.....::|.:|:    ||. ||:..  :|..|||.|||.:|::.|
  Fly  1007 PRLFTIHLTADVPTQNLPKAH----TCF-NRIDLPPYETYQLLCDKLTQAVEET 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	13/38 (34%)
		WW	103..132	CDD:459800	5/44 (11%)
		C2_Kibra	693..813	CDD:176062
Smurf	NP_523779.1	C2_Smurf-like	14..135	CDD:176028
		PRP40	155..>283	CDD:227435
		WW	169..198	CDD:459800
		WW	514..546	CDD:197736	6/26 (23%)
		WW	562..594	CDD:197736	14/31 (45%)
		HECTc	702..1058	CDD:238033	77/380 (20%)