DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and Smurf

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster

Alignment Length:	574	Identity:	118/574 - (20%)
Similarity:	189/574 - (32%)	Gaps:	176/574 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 HHLRPQQQQQQHHHHHQQQQQQQHTHHQQQQ---QH---HSDFPLPDGWDIAKDFDGKTYYIDHI 76
            :.:|..||.|.:.:|........|.....:.   ||   .:..|||.||:..|...|:.|::||.
  Fly   519 YEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTLDAIGPLPSGWEQRKTASGRVYFVDHN 583

  Fly    77 NKKTTWLDPR---------DCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQ------- 125
            |:.|.:.|||         ...|.|.|.....|...|        |:..|...:..|.
  Fly   584 NRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAP--------PSATPATPSAAAAVPPQATP 640

  Fly   126 ---------STQLEDPRQEWKTVQEQML--SDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHL 179
                     :|....|.:....:.:.:|  :|.|...:..|..|......:.|.:   |.:..|.
  Fly   641 ASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQTM---QPQSGHC 702

  Fly   180 KLAASRSSLCSSS----SSMSRHDPELLRADLM-------------LARERVHQLKQE------- 220
            :|..||:.:...|    ..|...|   :|..||             :|||.:|.|.:|
  Fly   703 RLEVSRNEIFEESYRLIMKMRAKD---MRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYG 764

  Fly   221 LTHITNDISYT-----ERGMNT-----LYSVGEKINAR--ENGCYDIAEVHAIREEMLKVHKSLV 273
            |...:.|..||     :.|:|.     .:.||..:...  ...|.|........:::|....:|.
  Fly   765 LFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLG 829

  Fly   274 SGEKVREELMRSLVQI--KNELG--RQQISEENSDLASPFDRVCVASQTDLCGSSGENLNGGARF 334
            ..|.|..:|.|||..:  .|..|  ....|.||:.    |..:.|          .|...|||..
  Fly   830 DIEGVDPDLHRSLTWMLESNISGIIESTFSVENNS----FGALVV----------HELKPGGASI 880

  Fly   335 AEMAKTKWQYAEW---RKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKL---------- 386
            ....:.|.:|.:.   .:.::.::||..    .::.|..|.....:|...::.:|
  Fly   881 PVTEENKREYVKLYVNYRFMRGIEQQFL----ALQKGFCELIPSHLLRPFDERELELVIGGISSI 941

  Fly   387 -LND-LNSISLKSRSEEEKRV-------------------------------------------- 405
             :|| .|:..||..:.|..:|
  Fly   942 DVNDWRNNTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVG 1006

  Fly   406 -----IHQTRHKLEEDLKEAYEANNTCVANRLRF--HEEKQLLLDKLQEALKST 452
                 ||.|.....::|.:|:    ||. ||:..  :|..|||.|||.:|::.|
  Fly  1007 PRLFTIHLTADVPTQNLPKAH----TCF-NRIDLPPYETYQLLCDKLTQAVEET 1055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	13/38 (34%)
		WW	103..132	CDD:278809	5/44 (11%)
		C2_Kibra	693..813	CDD:176062
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736	6/26 (23%)
		WW	562..594	CDD:197736	14/31 (45%)
		HECTc	702..1058	CDD:238033	77/380 (20%)
		HECTc	726..1058	CDD:214523	72/356 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900