DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and Hectd1

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_006240148.1	Gene:	Hectd1 / 362736	RGDID:	1561653	Length:	2610	Species:	Rattus norvegicus

Alignment Length:	1437	Identity:	256/1437 - (17%)
Similarity:	451/1437 - (31%)	Gaps:	492/1437 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 TFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQD----- 153
            |.|..:|.|...||.......:          .::||..:|:.:|:...:..|:..|.:.
  Rat   801 TAETSLGSEFVTGWTGKRGRKL----------KSKLEKTKQKVRTMARDLYDDHFKAVESMPRGV 855

  Fly   154 ---------QLENKREMFDVKQ-------QRLLWAQEEYNHLKLAASRSS-----LCSSSSSMSR 197
                     |||:..|:...:|       .|.|......|.:.|....|:     :|||.
  Rat   856 VVTLRNIATQLESSWELHTNRQCIEGENTWRDLMKTALENLIVLLKDESTISPYEMCSSG----- 915

  Fly   198 HDPELLRADLMLARERVH-QLKQELTHITNDISYTERGMNTLYSVGEKINARENGCYDIAEVHAI 261
                |::|.|.:....:. .:||:.:.:...|:.    ..|.:|..|...:|..... |.::.|:
  Rat   916 ----LVQALLTVLNSSIDLDMKQDCSQLVERINV----FKTAFSESEDDESRPAVAL-IRKLIAV 971

  Fly   262 RE--EMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDLCGSS 324
            .|  |.|.:|.....|.....:::...::.:.|             .:|       .:|.|...:
  Rat   972 LESIERLPLHLYDTPGSTYNLQILTRRLRFRLE-------------RAP-------GETALIDRT 1016

  Fly   325 GENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIEP-GQLESDKDRILLIQEKEKLLN 388
            |..|                                   ::|| ..:||.:..:|.:..|:....
  Rat  1017 GRML-----------------------------------KMEPLATVESLEQYLLKMVAKQWYDF 1046

  Fly   389 DLNSISLKSRSEEEKRVIHQTRHKLEE---------DLKEAYEANNTCVANR--LRFHEEKQLLL 442
            |.:|.....:..|.:..|.:.:|..:|         :.|.|||..|......  :...|.:.|..
  Rat  1047 DRSSFVFVRKLREGQNFIFRHQHDFDENGIIYWIGTNAKTAYEWVNPAAYGLVVVTSSEGRNLPY 1111

  Fly   443 DKLQEALKSTKLLEERLKSFSSESTFSISSG------------------SSLGSLSTASSKSALS 489
            .:|::.|...........:....:.|:|..|                  |:|.:.....||...:
  Rat  1112 GRLEDILSRDNSALNCHSNDDKNAWFAIDLGVWVIPSAYTLRHARGYGRSALRNWVFQVSKDGQN 1176

  Fly   490 FTDIY--IDPFAVDS-------PIDVVDLRR---RSQRLFQ--QHQQQRLH-----------PVH 529
            :|.:|  :|..:::.       |:|.....:   |..||.|  ::...:.|           .|:
  Rat  1177 WTSLYTHVDDCSLNEPGSTATWPLDPAKDEKQGWRHVRLKQMGKNASGQTHYLSLSGFELYGTVN 1241

  Fly   530 PVLQQQ-----QSAEVTLSPRSSLSMETPPASPMKYNA-GA-------------DQTPQA----- 570
            .|.:.|     :.||..|..:..|..    :..:||.. ||             |.:||.
  Rat  1242 GVCEDQLGKAAKEAEANLRRQRRLVR----SQVLKYMVPGARVIRGLDWKWRDQDGSPQGEGTVT 1302

  Fly   571 -----------------------------LKEEPTYANALPAPPAYTAPPPVPISGVRARPYDLD 606
                                         ||..|.|     .|....:|.||            .
  Rat  1303 GELHNGWIDVTWDAGGSNSYRMGAEGKFDLKLAPGY-----DPDTVASPKPV------------S 1350

  Fly   607 STVLDCMMLEAKLQKLNMGTPLNLA---------------VAPLSPIS------EKPSLLDLPQE 650
            |||.......:.|.|.|.....:.|               ||..|.||      |:.|.:.:...
  Rat  1351 STVSGTTQSWSSLVKNNCPDKTSAAAGSSSRKGSSSSVCSVASSSDISLGSTKTERRSEIVMEHS 1415

  Fly   651 MLS----------------------RSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRKELA 693
            ::|                      .|||:::|.:::|...:|:.....|...:.||   ..|.:
  Rat  1416 IVSGADVHEPIVVLSSAENVPQTEVGSSSSASTSTLTAETGSENAERKLGPDSSVRA---PGESS 1477

  Fly   694 QVQIGLKYLKQEGVLVVS-------------LERANNLL---ALWTASADNSQVYLRAALLPNSL 742
            .:.:|:..:....|..||             ...|:|.|   :|..|.|..|.    :|.:|| |
  Rat  1478 AISMGIVSVSSPDVSSVSELTNKEAASQRPLSSSASNRLSVSSLLAAGAPMSS----SASVPN-L 1537

  Fly   743 TSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPEDST 807
            :|..|.:|..|.:.|.|..                         :......:.:|.:..:...:|
  Rat  1538 SSRETSSLESFVRRVANIA-------------------------RTNATNNMNLSRSSSDNNTNT 1577

  Fly   808 LKWYNVLSSKFIP-----SFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQTST 867
            | ..||:|:...|     ||.:|..|.|::....:..:.:::.|........|...:::::.|::
  Rat  1578 L-GRNVMSTATSPLMGAQSFPNLTTPGTTSTVTMSTSSVTSSSNVATATTVLSVGQSLSNTLTTS 1641

  Fly   868 LTRNQAPCMELQE---------------QMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVSD 917
            ||...:.....||               .:.|||.....|.||   |::||:.|::..:.|...:
  Rat  1642 LTSTSSESDTGQEAEYSLYDFLDSCRASTLLAELDDDEDLPEP---DEEDDENEDDNQEDQEYEE 1703

  Fly   918 VGLMNSSSMLHAYLQNMKQEFADKETNTDRAYLPEKSRGQSQLMDDRPVKRSQTFTPSEAFSKNR 982
            |.::...|     ||......:|...:...:.||:...|..    .||:...:         :..
  Rat  1704 VMILRRPS-----LQRRAGSRSDVTHHAVTSQLPQVPSGAG----SRPIGEQE---------EEE 1750

  Fly   983 YNCRLNRS---DSD-------SAMHCGVAPHTFQRGAAERRSLRF------HSK---------AP 1022
            |..:..|.   |.|       ||:.....|...:....:...|..      ||:         :|
  Rat  1751 YETKGGRRRTWDDDYVLKRQFSALVPAFDPRPGRTNVQQTTDLEIPPPGTPHSELLEEVECTPSP 1815

  Fly  1023 KSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQ---NLK-----------------EV 1067
            :....|..|.: .|:.::||.|....|.:::...::.:|.   |:|                 |:
  Rat  1816 RLALTLKVTGL-GTTREVELPLSNFRSTIFYYVQKLLQLSCNGNVKSDKLRRIWEPTYTIMYREM 1879

  Fly  1068 LQKACENKDPLVAAWAIE-------------NEEFQRLVARADPAKCPEERQLQKLLMKTAKEIH 1119
            .....|.::..:..|:||             |:....|...||.|.....:     |..|.|.|.
  Rat  1880 KDSDKEKENGKMGCWSIEHVEQYLGTDELPKNDLITYLQKNADAAFLRHWK-----LTGTNKSIR 1939

  Fly  1120 KLRKTKVPKGCPDLV-SFKEKITFFTRKGLS-----------VPELPSEFTLPEA------NPI- 1165
            |.|      .|..|: ::|:.....||.||:           :..|..|  .|:|      ||.
  Rat  1940 KNR------NCSQLIAAYKDFCEHGTRSGLNQGASSSLQSSDILNLTKE--QPQAKAGNGQNPCG 1996

  Fly  1166 -----------------------EEEEEEEDENEFYNSAETAIAINTALVASSNRNKNLSEHPHR 1207
                                   :|:.:|:.:..|.....|:..|.|.::..       .|.|..
  Rat  1997 VEDVLQLLRILYIVASDPYSRISQEDGDEQPQFTFPPDEFTSKKITTKILQQ-------IEEPLA 2054

  Fly  1208 ATSGAVP 1214
            ..|||:|
  Rat  2055 LASGALP 2061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809	4/28 (14%)
		C2_Kibra	693..813	CDD:176062	24/135 (18%)
Hectd1	XP_006240148.1	Ank_2	366..457	CDD:289560
		ANK repeat	366..393	CDD:293786
		ANK	369..479	CDD:238125
		ANK repeat	396..426	CDD:293786
		ANK repeat	428..457	CDD:293786
		F5_F8_type_C	1107..1240	CDD:304887	20/132 (15%)
		MIB_HERC2	1277..1335	CDD:284184	7/57 (12%)
		HECTc	2131..2608	CDD:238033
		HECTc	2155..2607	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900