DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and Ube3a

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001178766.1	Gene:	Ube3a / 361585	RGDID:	1306361	Length:	868	Species:	Rattus norvegicus

Alignment Length:	918	Identity:	175/918 - (19%)
Similarity:	313/918 - (34%)	Gaps:	290/918 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 YYINHLAQSTQLE---DPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHL 179
            |..|....|...|   :.::|:|.|      |||:.     |...|:::..::|     |:|:.|
  Rat    94 YLENSKGASNNSEIKMNKKEEFKEV------DYLTE-----EKVYEIYEFCRER-----EDYSPL 142

  Fly   180 -----KLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELT------HITNDISYTER 233
                 ::.:|..:|..|...:.:|..|.|::......::....|::..      ...::.|.:..
  Rat   143 IRVIGRIFSSAEALVQSFRKVKQHTKEELKSLQEKDEDKDEDEKEKAACSAAAMEEDSEASSSRM 207

  Fly   234 GMNTLYSVGEKINARENGCYDI-AEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIK------- 290
            |.:   |.|:. |.::.|..|: .::.|||    :|:.||:|.||:....:.:||.:.
  Rat   208 GDS---SQGDN-NVQKLGPDDVTVDIDAIR----RVYSSLLSDEKIETAFLNALVYLSPNVECDL 264

  Fly   291 ----------NELGRQQISEENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEM-------A 338
                      |.|....|..||.:|.||                        .:.||       |
  Rat   265 TYHNVYTRDPNYLNLFIIVMENRNLHSP------------------------EYLEMALPLFCKA 305

  Fly   339 KTKWQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRI---LLIQE--KEKLLNDLNSISLKSR 398
            .:|...|...|.|:...:..||.:.|:    :|:.:..|   ::..|  ...|:||.::|...|:
  Rat   306 MSKLPLAAQGKLIRLWSKYSADQIRRM----METFQQLITYKVISNEFNSRNLVNDDDAIVAASK 366

  Fly   399 SEEEKRVIH--------QTRHKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALKSTKLL 455
            .  .|.|.:        .|.|. |||.:|.             ..|..:|.|.:|        |.
  Rat   367 C--LKMVYYANVVGGDVDTNHN-EEDDEEP-------------IPESSELTLQEL--------LG 407

  Fly   456 EERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQH 520
            |||.......                             :||...:..:..:|. |:....|::.
  Rat   408 EERRNKKGPR-----------------------------VDPLETEIGVKTLDC-RKPLISFEEF 442

  Fly   521 QQQRLHPVHPVLQQQQS-AEVTLSPRSSLSMETPP--ASPMKYNAGA--DQTPQALKEEP-TYAN 579
            ..:   |::.||:..:. ....:...:..|..|.|  .:.:..|.|.  |...:...|.. |...
  Rat   443 INE---PLNDVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLY 504

  Fly   580 ALPAPPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAVAPLSPIS-EKPS 643
            :|             :.|.:..||           |..|:::.::   ::.|:..|..|: |.|:
  Rat   505 SL-------------VQGQQLNPY-----------LRLKVRRDHI---IDDALVRLEMIAMENPA 542

  Fly   644 LLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRKELAQVQIGLKYLKQEGVL 708
              ||.:::.               |..|   |:.||.|...:    ||..|:.:  :.:....:.
  Rat   543 --DLKKQLY---------------VEFE---GEQGVDEGGVS----KEFFQLVV--EEIFNPDIG 581

  Fly   709 VVSLERANNLLALWTASADNS------QVYLRAALLPNSLTSIR------TKALGDFQKPVFNDT 761
            :.:.:.|..|.....:|.:..      .:.|..|:..|.:..:.      .|.:|  :|..|.|.
  Rat   582 MFTYDEATRLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMG--KKGTFCDL 644

  Fly   762 -FAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEF--NPEDSTLKWYNVLSSKFIPSFE 823
             .:.||     |.:||:..:......:::::.|.|||..:.  ||....||             |
  Rat   645 GDSHPI-----LYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLK-------------E 691

  Fly   824 SLD-IPSTSAAAAAAAVAASNAPNPGNNREE------------SSDESTITSSQTSTLTRNQAPC 875
            :.| ||.|:                 .||:|            |.::......:...:..|::|.
  Rat   692 NGDKIPITN-----------------ENRKEFVSLYSDYILNKSVEKQFKAFRRGFHMVTNESPL 739

  Fly   876 MELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSSMLHAYLQNMKQEFAD 940
            ..|......|||..|..|    .|....:|..|.|.......|.:.....::|::....|:.|..
  Rat   740 KYLFRPEEIELLICGSRN----LDFQALEETTEYDGGYTRESVVIREFWEIVHSFTDEQKRLFLQ 800

  Fly   941 KETNTDRA 948
            ..|.||||
  Rat   801 FTTGTDRA 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809	4/16 (25%)
		C2_Kibra	693..813	CDD:176062	25/134 (19%)
Ube3a	NP_001178766.1	AZUL	27..81	CDD:406862
Ube3a	NP_001178766.1	HECTc	516..866	CDD:238033	72/363 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900