DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and Ufd4

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster

Alignment Length:	1374	Identity:	262/1374 - (19%)
Similarity:	445/1374 - (32%)	Gaps:	389/1374 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 HHSDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEE---SY 111
            |..||          |.:|..:||....|...|::|........|..:  |..||.|..|   |.
  Fly  1126 HSFDF----------DEEGLLFYIGSNAKTCDWVNPAQYGLVQVTSSE--GKTLPYGKLEDILSR 1178

  Fly   112 DPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEY 176
            |         .::.:...:|.::.|..:.   |..|:......|.:.|.          :.:...
  Fly  1179 D---------SISLNCHTKDNKKAWFAID---LGVYIIPTAYTLRHARG----------YGRSAL 1221

  Fly   177 NHLKLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSV 241
            .:..|..|:..  |:.:::|.|                          .:|.|..|.|....:.:
  Fly  1222 RNWLLQGSKDG--STWTTLSTH--------------------------VDDKSLVEPGSTATWPI 1258

  Fly   242 G---------EKINARENGCYDIAEVHAIREEMLKVHKSLVS-----GEKVREELMRSLVQIKNE 292
            .         ..|..::||.....:.|.:.....:::..:|.     |:.|:|      .:.|..
  Fly  1259 NCATDDSVWYRHIRIQQNGRNASGQTHYLSLSGFEIYGRVVGVADDIGKSVKE------AEAKTR 1317

  Fly   293 LGRQQISEENSDLASPFDRVCVA-----SQTDLCGS---SGENLNGGARFAEMAKTKWQYAEWRK 349
            ..|:||..:...:.:. .||...     .:.|.|..   :||..||           |...:|..
  Fly  1318 RERRQIRAQLKHMTTG-ARVIRGVDWRWEEQDGCAEGTITGEIHNG-----------WIDVKWDH 1370

  Fly   350 HIK---------KLQQQLAD--HVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSR-SEEE 402
            .::         |...:|||  ::...:..|                   .:.|.|..:: ||:.
  Fly  1371 GVRNSYRMGAEGKYDLKLADCEYLSAFDGNQ-------------------SMGSASTAAKPSEKG 1416

  Fly   403 KRVIHQTRHKLEEDLKEAYE--------ANNTCVANRLRFHEEKQLLLDKLQEALKSTKLLEERL 459
            ...:...:......|.||.|        :|.|..|:.|.:.:..:.:.:.:..:.| |:::..:|
  Fly  1417 GNTLTSRKSSSTPSLPEATEKNQNPEGASNQTVSADNLAWKQTVETIAENVFASAK-TQIISNQL 1480

  Fly   460 KSFSSESTFSISSGSSLGSLSTASSKSALS------FTDIYIDPFAVDSPIDVVDLRRRSQRLFQ 518
                              :::|:||:.|.:      ...::.|..:..||:        |:.|..
  Fly  1481 ------------------AMNTSSSREARAKHKESGTNQMHKDNISGPSPL--------SRELEH 1519

  Fly   519 QHQQQRLHPVHPVLQQQQSAEV-TLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALP 582
            ......::...|.:.....::: |:|...||:      ...|.|.....||.....|...|:...
  Fly  1520 ISDLSAINNSMPAINSSNVSDLATISENLSLT------ELSKENICRVLTPSYKPAESVTASQSS 1578

  Fly   583 APPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLN------LAVAPLSPISEK 641
            :.|...:..|            .::.:.:...:|.. .|:|....:|      ||....|.|:..
  Fly  1579 SHPDVQSSSP------------RENDIKNISNIEEN-NKMNANNSVNKISKDLLANLRTSNIAGC 1630

  Fly   642 PSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLP----RKELAQVQIGLKYL 702
            |.:..|..|.|.......:...:...:||..::.|:  |.....::|    :...||..|.....
  Fly  1631 PPVTQLSTEALEMIDKMRDGVDMIRNMSNSILSTDT--FPVPCTNVPVGGKKTPKAQALINPDNA 1693

  Fly   703 KQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSLTSIRTKALGDFQKPVFNDTFAVP-- 765
            .|:.::|.|.|       ..|.|:....|.|:.|..||::.||    :...::|:.|:..:||
  Fly  1694 NQKQIIVTSEE-------FPTKSSKKPSVTLKPAQQPNAVLSI----VDIKEQPISNENVSVPSQ 1747

  Fly   766 --ITLDKLLTKSLQVT-----VVTMTGQKEEI-------------IGTVQISMAEFNPED----- 805
              |::..|.|.|....     |.|.||..|..             |...||..||.|..:
  Fly  1748 MSISVPNLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDNQIMNAEANVNEHGDQN 1812

  Fly   806 -----------STLKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASN----AP-NPGNNREES 854
                       |.:|.  .|||.|....       .|.|.:..:::::|    || ||.|.....
  Fly  1813 ASGSFLGHSVTSLVKL--ALSSNFHSGL-------LSTAQSYPSLSSNNSENIAPSNPSNTSAGQ 1868

  Fly   855 SDESTITSSQTSTLT-----RNQAPCMELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQL 914
            ...|||..:.|.:||     ..|....:..|...|..| ||.|::.:..|:|:|:||.| |:.:
  Fly  1869 QSASTINHTLTMSLTSTSSDSEQVSLEDFLESCRAPAL-LGDLDDEDDMDEDNDEEENE-DEYE- 1930

  Fly   915 VSDVGLMNSSSMLHAYLQNMKQEFADKETNTDRAYLPEKSRGQSQLMDDRPVKRSQTFTPSEAFS 979
              :||    :::|...:......|.|.|...:|.....|.:.    .||..|.:.|......||.
  Fly  1931 --EVG----NTLLQVMVSRNLLTFMDDEAMENRLVGVTKRKS----WDDEFVLKRQFSALIPAFD 1985

  Fly   980 KNRYNCRLNR-SDSDSAMHCGVAPHTFQRGAAERRSLRFHSKAPKSVTKLHHT---HIPRTSLDL 1040
            .......:|: ||.:.:......|...|.|..|.      .:.|....||...   .||...:||
  Fly  1986 PRPGRTNVNQTSDLEISPLGAELPKPQQSGGPET------IEQPLLGLKLRGPGIGGIPEVEIDL 2044

  Fly  1041 ELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACENK-DPLVAAWAIENEEFQRLVARADPAKCPEE 1104
            .             |......:.::|:||.:..|| |.....|    |....:|.|   ...||
  Fly  2045 S-------------NTDWTIFRAVQELLQCSQLNKLDKFRKIW----EPTYTIVYR---EVSPE- 2088

  Fly  1105 RQLQKLLMKTAKEIHKLRKTKVPKGCPDLVSFKEKITFFTRKGLSV--PELPSEF---------- 1157
                      |:|...|...:.|: .||:.|         :.|.|.  |..|...
  Fly  2089 ----------AQESTCLESEEFPQ-TPDVSS---------KSGASTLSPNSPMHIGFNVADNNLC 2133

  Fly  1158 -------TLPEANPIEEEEEEED----------ENEFYNSAET---AIAINTALVASSNRNKNLS 1202
                   .|.:.|.:.:.|.:.|          |:.|.:...|   ...|...||.:||...|..
  Fly  2134 SVDDVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWC 2198

  Fly  1203 EHPHRATSGAVPKIPAPVVTPAATPAATPAATPAATSAATPAATPVVSPAAQPDAKPADAPIPVA 1267
            |:.:::             .|...|..|.......||..  |:..:|...:|.|.......||:.
  Fly  2199 ENLNQS-------------CPFLFPFETRQLYFNCTSFG--ASRSIVCLQSQRDVTVERQRIPIM 2248

  Fly  1268 SNDAEQQRF 1276
            |...:...|
  Fly  2249 SPRRDDHEF 2257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	7/29 (24%)
		WW	103..132	CDD:278809	6/31 (19%)
		C2_Kibra	693..813	CDD:176062	37/157 (24%)
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041	22/174 (13%)
		MIB_HERC2	1333..1389	CDD:310955	11/67 (16%)
		DamX	1576..>1725	CDD:330571	32/170 (19%)
		HECTc	2265..2725	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900