DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kibra and CG4238

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster

Alignment Length:	426	Identity:	83/426 - (19%)
Similarity:	127/426 - (29%)	Gaps:	159/426 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   892 LNEPECSDDD-------------------DDDEEEELDDKQLVSDVGLMNSSSMLHA-----YLQ 932
            :.:..||.:|                   ..|.....|...|||.:   |...::||     ...
  Fly     1 MGQMHCSPEDASLRSDLVLIRSFVVYKGRPPDHATRFDISMLVSHI---NVGGVMHAATGGKTFP 62

  Fly   933 NMKQEFADKETNTDRAYLPEKSRGQSQLMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMH 997
            .:|.:....|           |.|.|.|......:|.....|.:       ..||.|    :|:|
  Fly    63 TLKVKLCFGE-----------SMGISSLSSCGDPERLPELPPLD-------EQRLQR----AALH 105

  Fly   998 CGVAPHTFQRGAAERRSLRFHSKAPKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLND------ 1056
                   .|:....|..|:.|        :|.| |..|. |.:|:   |....:|:|.|
  Fly   106 -------LQQKLILREWLKDH--------RLQH-HYQRL-LAVEV---ASLEDVYWLEDSRASKI 150

  Fly  1057 -----QI------------AKLQNLK----EVLQKACENKDPLVAAW--------AIENEEFQRL 1092
                 |:            |:|..||    ..:.|:.:::|    ||        ::.......|
  Fly   151 LGKDWQLWSGARQNLPTSKAQLDALKAQLWSTVVKSSQHQD----AWTWGGMLVVSVSVAGLVTL 211

  Fly  1093 VARADPAKCPEERQLQKLLMKTAKEIHKLRKTKVPKGCPDLVSFKEK----------ITFFTRKG 1147
            .|...|:..||.|. ..|...|.|.:       :|..|.....:|:.          :.||.|.|
  Fly   212 AAMTQPSLAPEARH-SLLQYVTGKYL-------LPANCKVQWDWKDPASVGGTMCFVVRFFQRNG 268

  Fly  1148 LSVPELPSEFTLPEAN-------PIEEEEEEEDENEFYNSAETAIAINTA-------LVASSNRN 1198
            ...|...::....|..       .|.|.....|.|. .|.|:....:.||       |:.:|
  Fly   269 QPYPICDTDHFFVEVTEGTRKVVTISELGSSTDPNN-ANIAKVKFTVRTAGQYKISVLIGAS--- 329

  Fly  1199 KNLSEHPHRATS--------GAVPKIPAPVVTPAAT 1226
                   |.|.|        ||:....:..:.||:|
  Fly   330 -------HIAGSPFLRSFLPGAIDARRSRFIRPAST 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809
		C2_Kibra	693..813	CDD:176062
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	22/108 (20%)
		Filamin	238..336	CDD:279024	22/108 (20%)
		HECTc	615..975	CDD:238033
		HECTc	642..974	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900