Protein Alignment kibra and Hecw2

DIOPT Version :10

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001001883.1
• Gene: Hecw2 / 329152
• MGIID: 2685817
• Length: 1578
• Species: Mus musculus
• Alignment Length: 418
• Identity: 75/418 - (17%)
• Similarity: 137/418 - (32%)
• Gaps: 161/418 - (38%)

  Fly    33 HQQQQQQQHTHHQQQQQHHSD------------FPLPDGWDIAKDFDGKTYYIDHINKKTTWLDP 85
            |...:.::.|||.::.||:.|            ..||.||::..|..||.:::||.::.||::||
Mouse   958 HMITKVRRDTHHFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDP 1022

  Fly    86 RDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQ-----------------LEDPR 133
            |                ||:   :|..|.....:..||.:...                 |..|.
Mouse  1023 R----------------LPL---QSSRPTSALVHRQHLTRQRSHSAGEVGEDSRHAGPPVLPRPS 1068

  Fly   134 QEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASRSSLCSSSSSMSRH 198
            ..:.||......|.:..|.    |.:.:..::|..:|...:|                      .
Mouse  1069 STFNTVSRPQYQDMVPVAY----NDKIVAFLRQPNILEILQE----------------------R 1107

  Fly   199 DPELLRADLMLARERVHQLKQE----LTHITNDISYTERGMNTLYSVGEKINARENGCYDIAEVH 259
            .|:|.|...:  ||::..::.|    |..:::|.                         |:..:.
Mouse  1108 QPDLARNHSL--REKIQFIRTEGTPGLVRLSSDA-------------------------DLVMLL 1145

  Fly   260 AIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDLCGSS 324
            ::.||      .::|.......|..|..|          |...|.::||
Mouse  1146 SLFEE------EIMSYVPPHALLHPSYCQ----------SPRGSPVSSP---------------- 1178

  Fly   325 GENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIE-------PGQLESDKDRILLIQE 382
             :|..|..|....|...::        :..:.:|.:...::|       ||:|:       ||..
Mouse  1179 -QNSPGTQRANARAPAPYK--------RDFEAKLRNFYRKLETKGYGQGPGKLK-------LIIR 1227

  Fly   383 KEKLLND-LNSISLKSRSEEEKRVIHQT 409
            ::.||.| .|.|...||.:.::..::.|
Mouse  1228 RDHLLEDAFNQIMGYSRKDLQRNKLYVT 1255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	12/29 (41%)
		WW	103..132	CDD:459800	7/45 (16%)
		C2_Kibra	693..813	CDD:176062
Hecw2	NP_001001883.1	HECW_N	45..162	CDD:465177
		C2_NEDL1-like	185..320	CDD:176073
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..453
		DMP1	<344..700	CDD:462128
		NESP55	<463..639	CDD:115071
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..802
		Interaction with TP73. /evidence=ECO:0000250	737..1074		29/134 (22%)
		WW	815..844	CDD:459800
		HECW1_helix	921..987	CDD:465766	7/28 (25%)
		WW	993..1024	CDD:197736	14/46 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1030..1075		6/44 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1167..1193		9/52 (17%)
		HECTc	1222..1576	CDD:238033	11/41 (27%)