DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kibra and Hecw2

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001001883.1	Gene:	Hecw2 / 329152	MGIID:	2685817	Length:	1578	Species:	Mus musculus

Alignment Length:	418	Identity:	75/418 - (17%)
Similarity:	137/418 - (32%)	Gaps:	161/418 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 HQQQQQQQHTHHQQQQQHHSD------------FPLPDGWDIAKDFDGKTYYIDHINKKTTWLDP 85
            |...:.::.|||.::.||:.|            ..||.||::..|..||.:::||.::.||::||
Mouse   958 HMITKVRRDTHHFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDP 1022

  Fly    86 RDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQ-----------------LEDPR 133
            |                ||:   :|..|.....:..||.:...                 |..|.
Mouse  1023 R----------------LPL---QSSRPTSALVHRQHLTRQRSHSAGEVGEDSRHAGPPVLPRPS 1068

  Fly   134 QEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASRSSLCSSSSSMSRH 198
            ..:.||......|.:..|.    |.:.:..::|..:|...:|                      .
Mouse  1069 STFNTVSRPQYQDMVPVAY----NDKIVAFLRQPNILEILQE----------------------R 1107

  Fly   199 DPELLRADLMLARERVHQLKQE----LTHITNDISYTERGMNTLYSVGEKINARENGCYDIAEVH 259
            .|:|.|...:  ||::..::.|    |..:::|.                         |:..:.
Mouse  1108 QPDLARNHSL--REKIQFIRTEGTPGLVRLSSDA-------------------------DLVMLL 1145

  Fly   260 AIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDLCGSS 324
            ::.||      .::|.......|..|..|          |...|.::||
Mouse  1146 SLFEE------EIMSYVPPHALLHPSYCQ----------SPRGSPVSSP---------------- 1178

  Fly   325 GENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIE-------PGQLESDKDRILLIQE 382
             :|..|..|....|...::        :..:.:|.:...::|       ||:|:       ||..
Mouse  1179 -QNSPGTQRANARAPAPYK--------RDFEAKLRNFYRKLETKGYGQGPGKLK-------LIIR 1227

  Fly   383 KEKLLND-LNSISLKSRSEEEKRVIHQT 409
            ::.||.| .|.|...||.:.::..::.|
Mouse  1228 RDHLLEDAFNQIMGYSRKDLQRNKLYVT 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	12/29 (41%)
		WW	103..132	CDD:278809	7/45 (16%)
		C2_Kibra	693..813	CDD:176062
Hecw2	NP_001001883.1	HECW_N	45..164	CDD:374632
		C2_NEDL1-like	185..320	CDD:176073
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..453
		DMP1	<344..700	CDD:369294
		NESP55	<463..639	CDD:115071
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..802
		Interaction with TP73. /evidence=ECO:0000250	737..1074		29/134 (22%)
		WW	815..844	CDD:366073
		HECW1_helix	921..987	CDD:375862	7/28 (25%)
		WW	993..1022	CDD:366073	11/28 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1030..1075		6/44 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1167..1193		9/52 (17%)
		HECTc	1222..1576	CDD:238033	11/41 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900