DRSC/TRiP Functional Genomics Resources

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Protein Alignment kibra and HUWE1

DIOPT Version :9

Sequence 1:NP_001034055.1 Gene:kibra / 41783 FlyBaseID:FBgn0262127 Length:1288 Species:Drosophila melanogaster
Sequence 2:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster


Alignment Length:1327 Identity:233/1327 - (17%)
Similarity:419/1327 - (31%) Gaps:430/1327 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 QQQQQHHSDF-------PLPDGWDIAK--------DFDGKTYYIDHINK-KTTWLDPRDCYTKPQ 93
            |.:|:..:|.       |.|:..:||:        .|..::.....:.| |.|:|.....:|.|.
  Fly  1219 QTRQRRINDLISNITKVPTPEAREIARILSSILVNGFSHESILPKPVPKLKLTFLICSVGFTGPM 1283

  Fly    94 TFED------------CVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLS- 145
            .|:|            |..:.|...:|..|    ....:::::|..:.:    :|.::::.|.| 
  Fly  1284 LFDDKRSAFHLMISQFCAENGLKAFFEMFY----WALSLDNVSQKFEFD----QWASMEDLMQSH 1340

  Fly   146 ------------DYLSAAQDQLE---NKREMFD-------------------------------V 164
                        ::|.|....||   |.|.|.|                               :
  Fly  1341 EDDKRDCPEGTGEFLDAWLQLLEKMVNPRAMLDSPYTMSPRLNYMPDSVPFEPVFYLIHIHQLAM 1405

  Fly   165 KQQRLLWAQEEYNHLKLAASRSSLCSSSSSMSRHDPELLRADLMLAR----------ERVHQLKQ 219
            :..|.:||:.                   .:..:.|.:....:::.:          :|.|...:
  Fly  1406 QALRRIWARR-------------------PIPNYGPSMFETMILILKHLIKSHQTLLDRYHTRMK 1451

  Fly   220 ELTHITNDISYTERGMN-----TLYSVGEKINARENGCYDIAEVHAIREEMLKVHKSLVSGEKVR 279
            |:......|..|:.|:|     ||..:|            ....|.|  |.|:.:.||       
  Fly  1452 EIKFENLYIRSTDDGLNADHIKTLTDMG------------FMHYHVI--EALRTNASL------- 1495

  Fly   280 EELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDL---CGSSGENLNGGARFAEMAKTK 341
            ||....|:.............::|..|.|......||..|:   ..:.||:..  ::.:....:.
  Fly  1496 EEATDYLLNNPEASSLSTTGGQSSSSAPPPPPPPSASTMDIDVDVPADGESTQ--SKSSTSPNSS 1558

  Fly   342 WQYAEWRKHIKKLQQQLADH------------VERIEPGQLESDKDRILLIQEKEKLLNDLNSIS 394
            :.|    ||:|.:...:.|.            :|.| |..:.|..|.|.::..:...||      
  Fly  1559 YDY----KHLKLMPSLIFDRFCDEAISRAFEFMEAI-PDTVNSAADLIAVLYRRHNHLN------ 1612

  Fly   395 LKSRSEEEKRVIHQTRHKLE--EDLKEAYEANNTCVANRLRFHE-EKQLLLDKLQEALK-STKLL 455
                  ::..|.:..|:.::  :...:.:|...|..:...|..| ...:...:|...|| ||.||
  Fly  1613 ------KQVFVTNFVRNIIQWVDFTLQLFEPAKTTGSKASRLEECLTGMTATRLFVRLKTSTLLL 1671

  Fly   456 EERLKSFSSESTFSISSGSSLGSL------------------STASSKSALSFTDIYIDPFAVDS 502
            ||...........:|::..::.||                  :|...::.:        |..|.:
  Fly  1672 EENYSDLHRPLVEAITAQDAMVSLVKLLDCMSQWMLEQSTETNTGQQRATV--------PRWVQN 1728

  Fly   503 PIDVVDLRRRSQRLFQQHQQQRLHPVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQT 567
            .:|::|               .:..:..:||::.:....    ||.......||..|:||.::..
  Fly  1729 LVDLID---------------AIDSISHILQRKANMRAV----SSDVWRWYDASTGKWNAYSEAN 1774

  Fly   568 PQALK------EEPTYAN----------------------------ALPAPPAYTA-PPPVPISG 597
            .:.::      |...|.|                            ||....|.|: ..||.:..
  Fly  1775 NELIRNAYAAGERWLYINIGRQRCTVSLNCMTQVSEASGTHRPVCPALKLSEAITSLNNPVALHK 1839

  Fly   598 --------VRARPYDLDSTVLDCMMLEAK-----------LQKLNMGTPLNLAVA---PLSPISE 640
                    ||..| |...||....::..:           .|..|...|...|.:   |.:..|.
  Fly  1840 VEHILNRVVRTAP-DGSGTVHSDELISLRQLVNFTDGQQPQQSENSANPSEEATSEDGPAAANSG 1903

  Fly   641 KPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRKE----LAQVQIGLKY 701
            .|     |..|.:||.:...:.:.:||..|:|.:|.|       ..:|::.    |.:.|:||..
  Fly  1904 SP-----PATMTTRSKTRQKSAAAAAAAKNKSQSGGS-------PPIPKRTQKIILNEEQVGLSK 1956

  Fly   702 L---KQEGVLVVSLERANNLL-----------ALWTASADNSQVYLR---AALLPNSLTSIRTKA 749
            .   :..|.:|..|:.::.:|           |..|.:.||:||::|   ..:|.:...:.....
  Fly  1957 FDCGRIIGSIVDLLQPSHQMLNETKLSLLRLCARLTRNYDNAQVFIRRGGVRMLLHLQQACSFMG 2021

  Fly   750 LGDFQKPVFNDTFAVPITLDKLLTK--SLQVTVVTMTGQKEEIIGTVQISMA-EFNPEDSTLKWY 811
            ...:...:.......|..|.:.:.:  .::...:...|.::.|....|:|.| ..||:.......
  Fly  2022 FPTYANIILRHVLEAPPVLQEAMERVLGMRAAGIVPVGHRDLIYVLTQVSSAVSRNPQIFVAAAK 2086

  Fly   812 NVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQTSTLTRNQAPCM 876
            .:|..:::.:..|    :|.|..|...|.:.....|             |::.......||.|  
  Fly  2087 EMLKGEYLINTNS----TTLADDARVMVKSKFGQQP-------------TAAAGGATPHNQTP-- 2132

  Fly   877 ELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSSMLHAYLQNM----KQE 937
                            ..|..:.|      |..||.|:.|.|.::  ..:||..:|..    ...
  Fly  2133 ----------------TPPPAAKD------ELKDDPQVQSSVAVL--KELLHGLVQPCWHYGGTG 2173

  Fly   938 FADKETNTDRAYLPEKSRGQSQ-LMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSDSA------ 995
            ..|:.........|::..|.:| ..||....|.|. ||:...||.:     :.|...:|      
  Fly  2174 SLDRGQGAAELLQPDQPPGTAQGCHDDELYFRFQE-TPAPVSSKKQ-----SSSGGGAAAAGQTG 2232

  Fly   996 ------------MHCGVAPHTFQRGAAERRSL---------RFHSKAPKSVTKLHHTHIPRTS-- 1037
                        .|...:.||..:....|.:|         .:.|..|:.:  |.|.:.|..|  
  Fly  2233 QATEKFEPCCCTWHIPTSGHTHAKPTISRATLLKLLADSTRAYQSLVPRVL--LSHVYTPADSPL 2295

  Fly  1038 ------------LDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACENKD----PLVAAWAIEN 1086
                        ||..|.:..:|        .:.::..:..||  .|...|    |.|.....  
  Fly  2296 ISAPQQTFLGVLLDRFLPITQRH--------HVPEVSTMTRVL--ICSLSDCYQQPGVQVHVA-- 2348

  Fly  1087 EEFQRLVAR--ADPAKCPEERQLQKLL 1111
            ||....|||  |.|....:..:||.|:
  Fly  2349 EELHAAVARALAQPDSAEKHTRLQVLM 2375

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kibraNP_001034055.1 WW 57..87 CDD:238122 8/38 (21%)
WW 103..132 CDD:278809 4/28 (14%)
C2_Kibra 693..813 CDD:176062 24/139 (17%)
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366 13/59 (22%)
WWE 1756..1828 CDD:128922 10/71 (14%)
40S_SA_C 3575..3651 CDD:292740
DUF4414 3675..3779 CDD:291075
HECTc 4796..5149 CDD:238033
HECTc 4820..5148 CDD:214523
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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