Protein Alignment kibra and smurf1

DIOPT Version :10

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001001943.1
• Gene: smurf1 / 321695
• ZFINID: ZDB-GENE-040426-2744
• Length: 731
• Species: Danio rerio
• Alignment Length: 566
• Identity: 122/566 - (21%)
• Similarity: 201/566 - (35%)
• Gaps: 146/566 - (25%)

  Fly    22 PQQQQQQHHHHHQQQQQQQHTHHQQQQQH-HSDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDP 85
            |.|:|:......:.|..:.|||..|.:.| |....||:|::......|:.|::......:||.||
Zfish   200 PNQEQRLQAQRIRNQDSRGHTHTPQNRPHGHQSPDLPEGYEQRTTVQGQVYFLHTQTGVSTWHDP 264

  Fly    86 RDCYTKPQTFEDCVGDE---LPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDY 147
            |    .|:.......:|   ||.|.|.....:...|:::|..::||..|||......|...:.:.
Zfish   265 R----IPRDLNSVSCEELGPLPPGREIRSTVSGRIYFVDHNNRTTQFTDPRLHHIMSQHSQVKES 325

  Fly   148 LSAAQDQLENKREMFD----------------VKQQRLLWAQEEYNHLKLAASRSSLCSSS-SSM 195
            ..|...|:|...|..|                |.:..|...|.:..|.::..||..:...| ..:
Zfish   326 SQALPVQMEVGMEEGDGELPVRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQI 390

  Fly   196 SRHDPELLRADLM-------------LARERVHQLKQELTH-----------------ITNDISY 230
            .:..|:.|:..||             :|||.::.|..|:.:                 |..|.|.
Zfish   391 MKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSI 455

  Fly   231 TERGMNTLYSVGEKINARE------NGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQI 289
            ....::..:.||..:....      ||.:.:    ...:::|.....|...|.|..||.:|||.|
Zfish   456 NPDHLSYFHFVGRIMGLAVFHGHYINGGFTL----PFYKQLLGKPIQLCDLETVDPELHKSLVWI 516

  Fly   290 KNELGRQQISEENSDLASPFDRV-CVAS-------QTDLCGSSGENLNGGARFAEMAKTKW--QY 344
            .          || |:.|..|.. ||..       |.:| ..:|:|:    ...|..|.::  .|
Zfish   517 L----------EN-DITSVLDHTFCVEHNAFGKFLQHEL-KPNGKNI----PVTEENKKEYVRLY 565

  Fly   345 AEWRKHIKKLQQQ---LADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVI 406
            ..|| .::.::.|   |......:.|..|....|.    :|.|.::..|..|.|..
Zfish   566 VNWR-FMRGIEAQFLALQKGFNELIPQHLLKPFDN----KELELIIGGLGKIDLND--------- 616

  Fly   407 HQTRHKLEEDLKEAYEANNT---CVA--NRLR--------FHEEKQLLLDKLQEALKSTKLLEER 458
                          ::||..   |||  |.::        |.||::..|  ||....||::   .
Zfish   617 --------------WKANTRLKHCVADSNIVKWFWQAVESFDEERRGRL--LQFVTGSTRV---P 662

  Fly   459 LKSFSSESTFSISSGSSLGSLSTASS------KSALSFTDIYIDPF 498
            |:.|.:....:.|:|..|.::....:      |:...|..|.|.|:
Zfish   663 LQGFKALQGSTGSAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPY 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	8/29 (28%)
		WW	103..132	CDD:459800	8/28 (29%)
		C2_Kibra	693..813	CDD:176062
smurf1	NP_001001943.1	C2_Smurf-like	14..138	CDD:176028
		WW	234..266	CDD:197736	10/35 (29%)
		WW	280..312	CDD:197736	10/31 (32%)
		HECTc	373..728	CDD:238033	79/389 (20%)