DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and CG42797

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	1062	Identity:	209/1062 - (19%)
Similarity:	345/1062 - (32%)	Gaps:	341/1062 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   423 ANNTCVANR-------LRFHEEKQLLLDKLQEALKSTKLLEERLKS-----FSSESTFSISSGSS 475
            |::.|:|:|       :|..:|:|...|..:|        ||..:.     ...|:.:...:|:.
  Fly    15 ASSACLADRSPVDPIAVRLQQEEQAEGDDEEE--------EEEEEDDDDDPKEEEAFYEARNGNE 71

  Fly   476 LGSLSTASSKSALSFT-DIYIDPFAVD--SPIDVVDLRRRSQRLFQ-QHQQQRLHPVHPVLQQQQ 536
            ...|..| .:|||:.| |:::....|:  .|    .|..|:|.:.: :.|||:|...  .|.|..
  Fly    72 SDELEQA-FQSALTLTNDVHVSVSEVEEHEP----PLASRNQEVAEVEEQQQQLGAC--ALPQPS 129

  Fly   537 SAEVTLS-----PR------SSLSMETP----PASPM-KYNA-----GADQTPQALKEEPTYANA 580
            .|.:|.|     ||      |:.|.|||    ..||. .||.     |........:.:
  Fly   130 EASLTGSKETREPRHHQTLLSTKSCETPANNATLSPTNSYNGSIGSDGGSSVGGGARRK------ 188

  Fly   581 LPAPPAYTAPP----PVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAVAPLSPISEK 641
                 ::|..|    ..|:||.:.:......|        ..|...| |...||.||       :
  Fly   189 -----SWTLSPQSGGSTPLSGAKKKTKTGAPT--------TTLSNAN-GDGFNLWVA-------R 232

  Fly   642 PSLLDLPQEMLSRSSSTSNTRSV-------SAAVSNESVAGDSGVFEASRAHLPRKELAQVQIGL 699
            .....:|.||:...|.......|       :|||  ||:.|.:...:|| ||:.|::..|..
  Fly   233 ECFETVPAEMVDTLSMAEVDEEVDEEEDEEAAAV--ESLLGAAAALQAS-AHVQRRQQQQHH--- 291

  Fly   700 KYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSLTSIRTKALGDFQKPVFNDTFAV 764
            ::|:|.     |..:...|...|...|....:.|:                ||    ||.  |.:
  Fly   292 QHLRQP-----SPPQHRPLERSWPPRAVGRDLKLQ----------------GD----VFQ--FDI 329

  Fly   765 PITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNP-------EDSTLKWYNVLSSKFIPSF 822
            ..|.::|..:..|       |........:......|.|       .||   :.|.:|::.:|..
  Fly   330 LDTDERLAEEMAQ-------GSGSSNNSPLATPPVRFKPLLKKKIGPDS---YINTISTQKVPVH 384

  Fly   823 ESLDIPSTSAAAAAAAVAASNAPNP----------------GNNREESSDESTI----------T 861
            :|.:.|:..:::|..  ::|::||.                .|.:..||:|...          .
  Fly   385 QSYEFPTFPSSSAVG--SSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQASPRLLLSPKRPR 447

  Fly   862 SSQTSTLTRNQAPC-MELQEQMAAELLGLG---------PLNEPECSDDDDDDEEEELDDKQLVS 916
            |..:...||:.:|. :.|..:..:...|.|         |...|..        ..:...::|:.
  Fly   448 SPPSGCSTRSASPLDISLSPEQHSPTRGRGVGGALQDAVPPGTPTF--------HGQRPQQRLLK 504

  Fly   917 DVG--------------------LMNSSSMLHAYLQNMKQEFA------------DKETNTDRAY 949
            .||                    .....:..||.||.:....:            ...:..|..|
  Fly   505 RVGGGAGAGATGGATGSPLVCPPTPTHHARRHARLQAVTANSSLASGGAIPSDPPAVSSQLDYIY 569

  Fly   950 LPEKSRGQSQLMDDRPVKRSQTFTPS---------EAFSKNRYNCRLNR------SDSDSAMHCG 999
            |.:..:.|.|...|..|..|.|..||         .|.:.......|..      |.|..|...|
  Fly   570 LQDGGQEQGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSGSSGAGAAG 634

  Fly  1000 VAP-------------------HT-----FQR-GAAERRSLRFHSKAPKSVTKLHHTHIPRTSLD 1039
            ..|                   ||     :|| |||.       |..|.. .:.||..
  Fly   635 EPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAP-------SGGPAG-REQHHRQ------- 684

  Fly  1040 LELDLQAQHSKLYFLND-QIAKLQNLKEVLQKACENKDPLV------------------------ 1079
             :||.:.|..:....|: :.|:|.||.........:..|..
  Fly   685 -QLDRRYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLH 748

  Fly  1080 ---AAWAI--ENEEFQRLV--ARADPAKCPEERQLQKLLM-------KTAKEIHKLRKTKVPK-G 1129
               ||.||  .|...:.:|  .|.|| .|.:..|..|.|:       :.::|:....:||:.: |
  Fly   749 TNEAALAIYNRNAALKHMVMRIRRDP-PCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSG 812

  Fly  1130 CPDLVSFKEKITFFTRKGLSVPELPSEFTLPEANPIEEEEEEEDENEFYNSAETAIAINTALVAS 1194
            ....:..:.:.|.|..     |.||.|......:..:..:::.....:|..    :.....|.|:
  Fly   813 KQFFIDHQHRRTSFMD-----PRLPVECPRVVRHRQQHSQQQSSVGYYYPD----LVDGNCLSAT 868

  Fly  1195 SNRNKNLSEHPHRATSGAVPKIPAPVVTPAATPAATPAA--------TPAATSAATPAATPVVSP 1251
            |.   :::..|..:.|| ||.:|.|  .|:::.:::.::        |.:|.|.|..|.......
  Fly   869 SG---HINASPASSVSG-VPPLPPP--RPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGA 927

  Fly  1252 AAQPDAKPADA---PIPVASND 1270
            |....|....|   .:|:|.|:
  Fly   928 AGMASAGATAAGYEDVPIAYNE 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809
		C2_Kibra	693..813	CDD:176062	21/126 (17%)
CG42797	NP_572574.2	WW	638..667	CDD:278809	3/28 (11%)
		HECTc	1068..1424	CDD:238033
		HECTc	1092..1423	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900