Protein Alignment kibra and Wwc3

DIOPT Version :10

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001414540.1
• Gene: Wwc3 / 317439
• RGDID: 1560666
• Length: 1214
• Species: Rattus norvegicus
• Alignment Length: 1241
• Identity: 384/1241 - (30%)
• Similarity: 611/1241 - (49%)
• Gaps: 207/1241 - (16%)

  Fly    45 QQQQQHHSDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEE 109
            |.:.:..::.|||.||:.|:|:||:.:||||..::|:|:||||..|||.||.||||||||:|||.
  Rat    50 QPRARESAELPLPAGWEEARDYDGRVFYIDHNTRQTSWIDPRDRITKPLTFADCVGDELPLGWET 114

  Fly   110 SYDPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQE 174
            .||..||.||::|:.:.||:||||::|:..||:||.:||..||:.|..|:|::.:||||...|||
  Rat   115 VYDKQIGIYYMDHINKLTQIEDPREQWRREQERMLKEYLIVAQEALNAKKEIYQIKQQRFELAQE 179

  Fly   175 EYNHL-KL----AASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERG 234
            ||..| ||    ..|.:|..|..|:.:::||..::|::...|:|:.:||:||..:..::.|.|:|
  Rat   180 EYQQLHKLCEDDGRSYTSSFSGYSTNTKYDPHQIKAEIASRRDRLSRLKRELAQMKQELQYKEKG 244

  Fly   235 MNTLYSVGEKINARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQI----KN---- 291
            :.||..:..|: :..:..|.:.|..||..|:..:.|::.:|||.|.:||:||.::    ||
  Rat   245 VETLQEIDRKM-SNTHTTYKLDEAQAIMSELRTIKKAICTGEKERRDLMQSLAKLTDSFKNSCSI 308

  Fly   292 ------------ELGRQQISEENSDLASPFDRVCVASQTDLCGSSGENL-NGGARFAEMAKTKWQ 343
                        .||....|::..|         ..||||   :.||.| :...|..:..:..||
  Rat   309 VDTLPDFSHSTGSLGNSGASQQFCD---------AGSQTD---TVGEFLFDDKTRLVDRVRLNWQ 361

  Fly   344 YAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQ 408
            |.|.||.:..:|||||.......||..|:|:||:.||:|||.||.:|..|..:.||.|:...:.:
  Rat   362 YEEARKRVSNIQQQLAQLANESWPGMAEADRDRLQLIKEKEALLQELQLIIQQRRSAEDVVRLEE 426

  Fly   409 TRHKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSG 473
            .|.:||::::.|...:......|:...|::..||.:|:||.:.|..|:.:|||.|: ||.::|||
  Rat   427 ERRRLEDEIQRARATSAQGATERILLQEKRNCLLMQLEEATRLTSYLQSQLKSLSA-STLTVSSG 490

  Fly   474 SSLGSL-----STASSK---SALSFTDIYIDPFAVDSPIDVVDLRR----------RSQRLFQQH 520
            ||.|||     |.|||:   |::||||||..|....:..:...|.|          |........
  Rat   491 SSRGSLASSRGSLASSRGSLSSISFTDIYGLPQYEKADAECGQLLRFDLIPFESLGRDVPFTDPQ 555

  Fly   521 QQQRLHPVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTP--QALKEEPTYANALPA 583
            .....|.....|...||. .:||.|||||..:||:||:       .||  .|.::.|    ....
  Rat   556 SHSGFHKQRKSLDTPQSL-ASLSSRSSLSSLSPPSSPL-------DTPFLTASRDSP----LAQM 608

  Fly   584 PPAYTAPPPVPISGVRARPYDL-DSTVLDCMMLEAKLQKLNMGTPLNLAVAPLSPISEKPSLLDL 647
            ...|.|.....:..:|::...| |..:....:|:.....::...|......|::|.|...:|.:.
  Rat   609 TDTYEAAGLGTLDRLRSQASTLGDEDLQGSAILQPHGIPVDGEGPRERGPQPVAPTSATVTLRED 673

  Fly   648 PQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFE-ASRAHLPRKELA----------QVQIGLKY 701
            ..:.|.|     ..|.|||.:|:.|:|.|||||| .::.:...:|.|          |:.:|..:
  Rat   674 SAKRLER-----RARRVSACLSDYSLASDSGVFEPLTKRNEDAEEPAFGDMYGNNEPQIYVGYLH 733

  Fly   702 LKQEGVLVVSLERANNLLALWTASADNSQVYLRAAL------LPNSLTSIRTKALGDFQKP-VFN 759
            ......|:|.:.:..||..|  ...::.::::|..|      .||:..|   |:| :||.| |||
  Rat   734 DSTNEYLLVHVLQLRNLAGL--VMKEDCKIHIRVYLPPLDSGTPNTYCS---KSL-EFQAPLVFN 792

  Fly   760 DTFAVPITLDKLLTKSLQVTVVTMTGQ-KEEIIGTVQISMAEF-NPEDSTLKWYNVLSSKFIPSF 822
            :.|.:|:....|..||||:.|.::..| :||::|..||::|:. :..:..|:||.|
  Rat   793 EVFRIPVHSSMLTLKSLQLYVCSVNPQLQEELLGIAQINLADCDSSSEMQLRWYPV--------- 848

  Fly   823 ESLDIPSTSAAAAAAAVAASNAPNPGNNRE------ESSDESTITSSQTST------LTRNQAPC 875
                           .|.||  |:|...:|      ||:.:.|:.:|...|      |.|..|..
  Rat   849 ---------------QVFAS--PDPPRPKEPVLRVMESTTQETMNTSSGKTDAVTVLLARTTAQL 896

  Fly   876 MELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVS---DVGLMN--------------S 923
            ..::.::|.|.:.|....|.....:..:::.|.:.::...:   |.|..|              .
  Rat   897 RAVERELAQERVKLEYTEEEILEMERKEEQGEAVSERSWQADSVDSGCSNCIQTSPQYPNSCYIG 961

  Fly   924 SSMLHAYL-----QNMKQE-------FADKETNTDRAYLPE-----------KSRGQSQLMDDRP 965
            :..:|.::     .:.|.|       ..||||.|:..|:.|           ::|| |..:....
  Rat   962 ADSIHGHVVTGQADSYKAEKLQPLPLKVDKETTTEDLYMEEALAVRKEWPSRRARG-SPFVRSST 1025

  Fly   966 VKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHT--FQRGAAERRSLRFHSKAPKSVTKL 1028
            :.|||||:|.   ::::|.|||.||||||:    ..|..  |.|...|||:||:......|:.:|
  Rat  1026 IVRSQTFSPG---ARSQYVCRLYRSDSDSS----TLPRKSHFIRNTLERRTLRYKQSCRSSMAEL 1083

  Fly  1029 HHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACENKDPLVAAWAIENEEFQRLV 1093
                :.||||||||||||..::...||::|..|:.|::.|:.|.......:..|.:.:|.|:.|:
  Rat  1084 ----MARTSLDLELDLQASRTRQRQLNEEIGTLRELRQRLEDAQLRGQTDLPHWVLRDERFRSLL 1144

  Fly  1094 ARAD------PAKCPEERQLQKLLMKTAKEIHKLR--KTKVPKGCPDLVSFKEKITFFTRKGLSV 1150
            ..|:      .....:|:..:|:|.|.:|||::||  ..|.|   ..:.:|:|||.||||..:::
  Rat  1145 KEAERQTRQTKLDYHQEQVAEKMLKKASKEIYQLRGQNHKEP---IQVQTFREKIAFFTRPRINI 1206

  Fly  1151 PELPSE 1156
            |.||::
  Rat  1207 PPLPAD 1212

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	15/29 (52%)
		WW	103..132	CDD:459800	15/28 (54%)
		C2_Kibra	693..813	CDD:176062	39/138 (28%)
Wwc3	NP_001414540.1	None