DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and Trip12

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_038939619.1	Gene:	Trip12 / 316575	RGDID:	1306607	Length:	2074	Species:	Rattus norvegicus

Alignment Length:	1082	Identity:	202/1082 - (18%)
Similarity:	339/1082 - (31%)	Gaps:	364/1082 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 RADLMLARERVHQLKQELTHITNDISYTERG------MNTLYSVGEKINARENGCYDIAEVHAIR 262
            |.|..:.....||:.::      :||.:..|      .|::..:.|          |.....||:
  Rat   828 RIDSRIIEVAAHQVGED------EISLSTLGRVYTIDFNSMQQINE----------DTGTARAIQ 876

  Fly   263 EEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDLCGSS-GE 326
            .:...:..:..||..          .:|.:..|.|:.:|:.:||..|.:.......::..|| |.
  Rat   877 RKPNPLANTNTSGYS----------DLKKDDARAQLMKEDPELAKSFIKTLFGVLYEVYSSSAGP 931

  Fly   327 NLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILL--IQEKEKLLND 389
            .:......|.:....:..||..|.:.| ...::.|:    ...|.|...:|::  :|..|.|:..
  Rat   932 AVRHKCLRAILRIIYFADAELLKDVLK-NHAVSSHI----ASMLSSQDLKIVVGALQMAEILMQK 991

  Fly   390 LNSI-SLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALKSTK 453
            |..| |:..|.|   .|:||.:|..|                                    |..
  Rat   992 LPDIFSVYFRRE---GVMHQVKHLAE------------------------------------SES 1017

  Fly   454 LLEERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQ 518
            ||....|:.::.|       .||||.:.|||.:|.:.|:...|..:
  Rat  1018 LLTSPPKACTNGS-------GSLGSTTPASSGTATAATNASADLGS------------------- 1056

  Fly   519 QHQQQRLHPVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALPA 583
                       |.||..:...:.|||:..||                   ..||.:...... |.
  Rat  1057 -----------PSLQHSRDDSLDLSPQGRLS-------------------DVLKRKRLPKRG-PR 1090

  Fly   584 PPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAVAPLSPISEKPSLL-DL 647
            .|.|:.|              .|...:|                 |.|.:|.:..|.|.|.| .|
  Rat  1091 RPKYSPP--------------RDDDKVD-----------------NQAKSPTTTQSPKSSFLASL 1124

  Fly   648 PQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRKELAQVQIGLK---------YLK 703
            ..:...|.|:.||:.::..|    ..||.||:..|:..........:::..:|         |..
  Rat  1125 NPKTWGRLSAQSNSNNIEPA----RTAGVSGLARAASKDTISNNREKIKGWIKEQAHKFVERYFS 1185

  Fly   704 QEGVLVVSLERAN---NLLALWTASAD--NSQVYLRAALLPNSLTSIRTKALGDFQKPVFNDTFA 763
            .|     :::.:|   |:|....|:.:  |.||...|..|....:.:....:..|:  :.:..|.
  Rat  1186 SE-----NMDGSNPALNVLQRLCAATEQLNLQVDGGAECLVEIRSIVSESDVSSFE--IQHSGFV 1243

  Fly   764 VPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPEDSTLKWYNVLSSKFIPSFESLD-I 827
            ..:.|           .:|...:|:.:...:::.           ::.:|..|..:|..|.:. :
  Rat  1244 KQLLL-----------YLTSKSEKDAVSREIRLK-----------RFLHVFFSSPLPGEEPVGRV 1286

  Fly   828 PSTSAAAAAAAVAASNAPN---------------PGNNREESSDESTITSSQTSTLTRNQAPCME 877
            .....|...|.|...|  |               |..|....|......|........:|..| :
  Rat  1287 EPVGHAPLLALVHKMN--NCLSQMEQFPVKVHDFPSGNGSGGSFSLNRGSQALKFFNTHQLKC-Q 1348

  Fly   878 LQEQ----------------------MAAE-------LLGLGPLNEPECSDDDDDDEEEELDDKQ 913
            ||..                      .|.|       :...|.:.|.: .|.|||..:||:|:..
  Rat  1349 LQRHPDCANVKQWKGGPVKIDPLALVQAIERYLVVRGIFRYGRVREDD-EDSDDDGSDEEIDESL 1412

  Fly   914 LVSDVGLMNSSSMLHA---YL------------QNMKQ---EFADKETNTDRAYLPEKSRG---Q 957
            ...   .:||.::.|.   |:            |.::|   :..|:..:||....|....|   :
  Rat  1413 AAQ---FLNSGNVRHRLQFYIGEHLLPYNMTVYQAVRQFSVQAEDERESTDDESNPLGRAGIWTK 1474

  Fly   958 SQLMDDRPVK---------------RSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHTFQR 1007
            :..:..:||:               |:|| .|::...:       |....|...|.||.|
  Rat  1475 THTIWYKPVREDEESSKDCVGGKRGRAQT-APTKTSPR-------NAKKHDELWHDGVCP----- 1526

  Fly  1008 GAAERRSLRFHSKAPKSVTKLHHTHIPRTSLDLELDLQAQHS---KLYFLNDQIAKLQNLKEVLQ 1069
            ..|....:......|:::|      ....|||:.|.|:..|:   ..|:|.|...    .||:
  Rat  1527 SVANPLEVYLIPTPPENIT------FEDPSLDVILLLRVLHAISRYWYYLYDNAM----CKEI-- 1579

  Fly  1070 KACENKDPLVAAWAIENEEF--QRLVARADPAKCPEERQLQKLLMKTAKEIHKLRKTKVPKGCPD 1132
                          |...||  .:|.|:|:       ||||..|:.....| ....|::.|.||.
  Rat  1580 --------------IPTSEFINSKLTAKAN-------RQLQDPLVIMTGNI-PTWLTELGKTCPF 1622

  Fly  1133 LVSFKEK-----ITFFTRKGLSVPELPSEFTLPEANPIEEEE 1169
            ...|..:     :|.|.|.......|.   |.||.|..:.::
  Rat  1623 FFPFDTRQMLFYVTAFDRDRAMQRLLD---TNPEINQSDSQD 1661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809
		C2_Kibra	693..813	CDD:176062	17/133 (13%)
Trip12	XP_038939619.1	SRP1	489..>714	CDD:227396
		WWE	814..876	CDD:397111	11/63 (17%)
		HECTc	1672..2072	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900