Protein Alignment kibra and Wwc1

DIOPT Version :9

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_002727807.1
• Gene: Wwc1 / 303039
• RGDID: 1308329
• Length: 1108
• Species: Rattus norvegicus
• Alignment Length: 1220
• Identity: 410/1220 - (33%)
• Similarity: 616/1220 - (50%)
• Gaps: 234/1220 - (19%)

  Fly    53 DFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGP 117
            :.|||:||:.|:|||||.|||||.|:.|:|:||||.||||.||.||:.||||:||||:|||.:|.
  Rat     5 ELPLPEGWEEARDFDGKVYYIDHRNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQVGD 69

  Fly   118 YYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHL--- 179
            |:|:|..::||:||||.:|:..||.||.|||..||:.|..::|::.||||||..||:||..|
  Rat    70 YFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELAQQEYQQLHAV 134

  Fly   180 ---KLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSV 241
               || .|:.||.|.|||.|::|||:|:|::..|:.||::||:|:.|:.:::.:.|||..||..:
  Rat   135 WEHKL-GSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHELQFKERGFQTLKKI 198

  Fly   242 GEKINARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIK----------NELGRQ 296
            .|:::..:.| |.:.|..|:..|...:.|::..|||.:::|::||..:|          ::|...
  Rat   199 DERMSDAQGG-YKLDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAMLKDGFRTDRGSHSDLWSS 262

  Fly   297 QISEENSDLASPFDRVCVASQTDLCGS---SGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQL 358
            ..|.|:|....|...:.|:||||:.||   |..|     :.||..:.:.:|.|.::.|..|:.||
  Rat   263 SSSLESSSFPVPKQFLDVSSQTDISGSFSTSSSN-----QLAEKVRLRLRYEEAKRRIANLKIQL 322

  Fly   359 ADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEA 423
            |.......||.|:|::||::||.|||:||.::..||.:..::.|...:...|.:||:||:.|.:.
  Rat   323 AKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPRKWTQGEVEQLEMARRRLEKDLQAARDT 387

  Fly   424 NNTCVANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSL--------- 479
            .:..:..||:.:.::..|:.:|:||.:....|..:|||.|| |..|:|||||.|||
  Rat   388 QSKALTERLKLNSKRNQLVRELEEATRQVAALHSQLKSLSS-SMQSLSSGSSPGSLTSSRGSLAA 451

  Fly   480 STASSKSALSFTDIYIDPF-AVDSPIDVVDLRRRSQRLFQQ--------------HQQQ------ 523
            |:..|.::.||||:|.||| .:||     :|..:.:.||.:              |:.:
  Rat   452 SSLDSSTSASFTDLYYDPFEQLDS-----ELPSKVELLFLEGATGFRPSGCITTIHEDEVAKTQK 511

  Fly   524 -----RLHPVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALPA 583
                 ||..:..:....:|. .:||||||||..:||.||:                  .|:.|.|
  Rat   512 AEGGSRLQALRSLSGTPRSM-TSLSPRSSLSSPSPPCSPL------------------IADPLLA 557

  Fly   584 PPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTP-----LNLAVAPLSPISEKPS 643
            ..|:..            |.:.:.|.|...:.|     |::||.     ..|         |:|.
  Rat   558 GDAFLT------------PLEFEDTELSPTLCE-----LSLGTDGARERFRL---------EEPG 596

  Fly   644 LLDLPQEMLSRSSSTS-----NTRSVSAAVSNESVAGDSGVFEASRAHLPRKELA---------- 693
            ....|   |.:::|.:     ....||||||:|||||||||:|||...|...|.|
  Rat   597 PEGKP---LGQAASVAPGCGLKVACVSAAVSDESVAGDSGVYEASMQRLGTSEAAAFDSDESEAV 658

  Fly   694 ---QVQIGLKY---LKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSLTS---IRTKA 749
               ||||.|||   .||..:||:.|...:.||.     ..:.:|.:|.|:||.|.:|   .||:.
  Rat   659 GVTQVQIALKYDEKSKQFAILVIQLSNLSALLL-----QQDQKVNIRVAILPCSESSTCLFRTRP 718

  Fly   750 LGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTM-TGQKEEIIGTVQISMAEF--NPEDSTLKWY 811
            |......|||:.|.|.::...|..|:|:|.|.|. ....||.:|..|||:||.  :.|.|| :||
  Rat   719 LDSADSLVFNEAFWVSMSYPALHQKTLRVDVCTTDRSHTEECLGGAQISLAEVCRSGERST-RWY 782

  Fly   812 NVLSSKFIPSF----ESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQTSTLTRNQ 872
            |:||.|::...    :..:.|......|.:|:....|......:|..|...|:..|.|
  Rat   783 NLLSYKYLKKQGREPQPAEAPGPDHVDAVSALLEQTAVELEKRQEGRSSSQTLEGSWT------- 840

  Fly   873 APCMELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSSMLHAYLQNMKQE 937
                                .|.|.|:::...||||.::::...||           :.:.:..|
  Rat   841 --------------------YEEEASENEAVAEEEEREEEEGEEDV-----------FAEKVSPE 874

  Fly   938 F-------ADKETNTD------RAYLPEKSR----GQSQLMDDRPVKRSQTFTPSEAFSKNRYNC 985
            .       .|:|||||      ....|:..|    .....:....:.||:||:|.   .:::|.|
  Rat   875 AEECPALKVDRETNTDSVTPSPTVVRPKDRRVGAPSPGPFLRGNTIIRSKTFSPG---PQSQYVC 936

  Fly   986 RLNRSDSDSAMHCGVAPHTFQRGAAERRSLRFHSKAPKSVTKLHHTHIPRTSLDLELDLQAQ--- 1047
            |||||||||:......|  |.|.:.||||:|.  |.|.||..|....:.||||||||||||.
  Rat   937 RLNRSDSDSSTLSKKPP--FVRNSLERRSVRM--KRPSSVKSLRTERLIRTSLDLELDLQATRTW 997

  Fly  1048 HSKLYFLNDQIAKLQNLKEVLQKACENKDPLVAAWAIENEEFQRLV----ARADPAKCPEERQLQ 1108
            ||:   |..:|:.|:.|||.|::|..:.:..:..|..|:|.|:.|:    .|.|..:...|.|..
  Rat   998 HSQ---LTQEISVLKELKEHLEQAKNHGEKELPQWLREDERFRLLLRMLEKRVDRGEHKSELQAD 1059

  Fly  1109 KLLMKTAKEIHKLR--KTKVPKGCPDLVSFKEKITFFTRKGLSVPELPSE 1156
            |::...||::|:||  ..|.|   |::.||:||:.||||..:::|.|.::
  Rat  1060 KMMRAAAKDVHRLRGQSCKEP---PEVQSFREKMAFFTRPRMNIPALSAD 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	19/29 (66%)
		WW	103..132	CDD:278809	16/28 (57%)
		C2_Kibra	693..813	CDD:176062	49/141 (35%)
Wwc1	XP_002727807.1	WW	9..39	CDD:238122	19/29 (66%)
		WW	55..84	CDD:278809	16/28 (57%)
		ALDH-SF	378..>420	CDD:299846	10/41 (24%)
		C2_Kibra	661..784	CDD:176062	48/128 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350919
Domainoid	1	1.000	258	1.000	Domainoid score	I1933
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	538	1.000	Inparanoid score	I1149
OMA	1	1.010	-	-		QHG50236
OrthoDB	1	1.010	-	-		D181722at33208
OrthoFinder	1	1.000	-	-		FOG0003726
OrthoInspector	1	1.000	-	-		otm45932
orthoMCL	1	0.900	-	-		OOG6_103792
Panther	1	1.100	-	-	O	PTHR14791
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1418
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770