DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kibra and Bag3

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_038891.4	Gene:	Bag3 / 29810	MGIID:	1352493	Length:	577	Species:	Mus musculus

Alignment Length:	471	Identity:	106/471 - (22%)
Similarity:	169/471 - (35%)	Gaps:	143/471 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 ERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDI---YIDPFAVDSPIDVVD----LRRRSQ 514
            ||.:|.::....|.||.:||.|    |.:|:|....:   ||       ||.|:.    .|..:|
Mouse   175 ERSQSPAASDCSSSSSSASLPS----SGRSSLGSHQLPRGYI-------PIPVIHEQNITRPAAQ 228

  Fly   515 RLFQQHQQQRLH---------PVHPVLQQQQ----------SAEVTLSP-RSSLSMETPPA---- 555
            ..|  ||.|:.|         |..||..:.|          :|....|| |.:.|.|..||
Mouse   229 PSF--HQAQKTHYPAQQGEYQPQQPVYHKIQGDDWEPRPLRAASPFRSPVRGASSREGSPARSGT 291

  Fly   556 -----SPMKYNAGADQ-TPQALKEEPTYA------NALPAPPAYTAPP-PVPISGVRARPYDLDS 607
                 ||::.:...|: .|...:|.|...      .:.|.|.....|| .:||..:|.
Mouse   292 PVHCPSPIRVHTVVDRPQPMTHREPPPVTQPENKPESKPGPAGPDLPPGHIPIQVIRR------- 349

  Fly   608 TVLDCMMLEAKLQKLNMGTP-------LNLAVAPL---SPISEKPSLLDLPQEMLSRSSSTSNTR 662
                    ||..:.::..:|       :.::.||:   || |..||.:..|.:.::     :..:
Mouse   350 --------EADSKPVSQKSPPPAEKVEVKVSSAPIPCPSP-SPAPSAVPSPPKNVA-----AEQK 400

  Fly   663 SVSAAVSNESVAGDSGVFEASRAHLPRKELAQVQIGLKYLKQEGVL--VVSLERANNLLALWTAS 725
            :..:....|..|..||..|....| |         |:  ||.|.:|  |..||:|.:  :.....
Mouse   401 AAPSPAPAEPAAPKSGEAETPPKH-P---------GV--LKVEAILEKVQGLEQAVD--SFEGKK 451

  Fly   726 ADNS----QVYLRAALLPNSLTSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSL----QVTVVT 782
            .|..    :.||...||  :|.|:..:...|.::...:....|...|:||..|::    ||.|..
Mouse   452 TDKKYLMIEEYLTKELL--ALDSVDPEGRADVRQARRDGVRKVQTILEKLEQKAIDVPGQVQVYE 514

  Fly   783 MTGQK-------EEIIGTVQISMAEFNPEDSTLKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVA 840
            :....       :||:|.|.....:..||:..            |..||..:.:          .
Mouse   515 LQPSNLEAEQPLQEIMGAVVADKDKKGPENKD------------PQTESQQLEA----------K 557

  Fly   841 ASNAPNPGNNREESSD 856
            |:..|||.|..:.:.:
Mouse   558 AATPPNPSNPADSAGN 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809
		C2_Kibra	693..813	CDD:176062	31/136 (23%)
Bag3	NP_038891.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81
		WW	23..55	CDD:197736
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..207		12/35 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..427		48/230 (21%)
		BAG	426..503	CDD:214591	21/82 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..577		14/72 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900