Protein Alignment kibra and Wwp1

DIOPT Version :10

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_006237992.1
• Gene: Wwp1 / 297930
• RGDID: 1311734
• Length: 968
• Species: Rattus norvegicus
• Alignment Length: 466
• Identity: 97/466 - (20%)
• Similarity: 161/466 - (34%)
• Gaps: 127/466 - (27%)

  Fly    21 RPQQQQQQHHHHHQQQQQQQHTHHQQQQQHH----------SD--FPLPDGWDIAKDFDGKTYYI 73
            ||..:..::....|.|:.|.....||..|.:          :|  .|||.||:...|...:.|::
  Rat   457 RPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFV 521

  Fly    74 DHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKT 138
            :|..|.|.|.|||   |:....|    :.||.|||..|......|:::|..::|..:|||....:
  Rat   522 NHNTKTTQWEDPR---TQGLPNE----EPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSS 579

  Fly   139 VQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEY--------NHLKLAASRSSLCSSS-SS 194
            |         :....|:..:|..      |...|...|        :|:|:..||.:|...| ..
  Rat   580 V---------TKGGPQIAYERSF------RWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQ 629

  Fly   195 MSRHDPELLRADLM-------------LARERVHQLKQELTHITNDISYTERGMNTLYSVGEKIN 246
            :....|..||..|.             ||||....|..|:             :|.:|.:.| ..
  Rat   630 IMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEV-------------LNPMYCLFE-YA 680

  Fly   247 ARENGCYDIAEVHAIREE--------------------------MLKVHKSLVSG-------EKV 278
            .:.|.|..|.....|..:                          .|..:|.::|.       |.:
  Rat   681 GKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESI 745

  Fly   279 REELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQ 343
            ..|...||:.|::    ..|.|...::....|...:...|     |.:...||:......:.|.:
  Rat   746 DTEFYNSLIWIRD----NNIEECGLEMYFSVDMEILGKVT-----SHDLKLGGSNILVTEENKDE 801

  Fly   344 Y----AEWR--KHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEE 402
            |    .|||  :.:::..:...|....:.|.|.....|.    :|.|.:|..:..:.|   ::.:
  Rat   802 YIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDE----KELEVMLCGMQEVDL---ADWQ 859

  Fly   403 KRVI--HQTRH 411
            :..:  |.||:
  Rat   860 RNTVYRHYTRN 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	11/29 (38%)
		WW	103..132	CDD:459800	9/28 (32%)
		C2_Kibra	693..813	CDD:176062
Wwp1	XP_006237992.1	C2_E3_ubiquitin_ligase	67..190	CDD:175988
		DUF5585	<196..>431	CDD:465521
		WW	397..426	CDD:459800
		HUL4	<427..968	CDD:227354	97/466 (21%)