Protein Alignment kibra and Wwp2

DIOPT Version :9

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001099654.1
• Gene: Wwp2 / 291999
• RGDID: 1310091
• Length: 870
• Species: Rattus norvegicus
• Alignment Length: 506
• Identity: 97/506 - (19%)
• Similarity: 168/506 - (33%)
• Gaps: 174/506 - (34%)

  Fly     5 QQTASQSQHHLHPHHLRPQ--QQQQQHHHHHQQQQQQQHTHHQQQQQHHSD-------------- 53
            ::|..:.:.:...|:.|..  |:....:..:.:|.|.|....|...||.|.
  Rat   338 KRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHD 402

  Fly    54 --FPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIG 116
              .|||.||:..:| :|:.||::|..:.|.|.|||   |:....|..    ||.|||..|.....
  Rat   403 PLGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPR---TQGMIQEPA----LPPGWEMKYTSEGV 459

  Fly   117 PYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEY----- 176
            .|:::|..::|..:|||..:::                 ..|:......::...|...::
  Rat   460 RYFVDHNTRTTTFKDPRPGFES-----------------GTKQGSPGAYERSFRWKYHQFRFLCH 507

  Fly   177 -----NHLKLAASRSSLCSSS----SSMSRHDPELLRADLM-------------LARERVHQLKQ 219
                 :|:|::.||.:|...|    .:|..:|   ||..|.             :|||....|..
  Rat   508 SNALPSHVKISVSRQTLFEDSFQQIMNMKPYD---LRRRLYIIMRGEEGLDYGGIAREWFFLLSH 569

  Fly   220 ELTHITNDISYTERGMNTLYSVGEKINARENGCYDIAEVHAIR---------------------- 262
            |:             :|.:|.:.| ...:.|.|..|....:|.
  Rat   570 EV-------------LNPMYCLFE-YAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGK 620

  Fly   263 -----------EEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVAS 316
                       :.||....:|...|.:..|...|::.||          ||:
  Rat   621 FIDTGFTLPFYKRMLNKRPTLRDLESIDPEFYNSIIWIK----------ENN------------- 662

  Fly   317 QTDLCG---------------SSGENLNGGARFAEMAKTKWQY----AEWR--KHIKKLQQQLAD 360
             .|.||               ::.|...||.......:.|.:|    .:||  :.:::..:...|
  Rat   663 -LDECGLELFFIQDMEILGKVTTHELKEGGENIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLD 726

  Fly   361 HVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRH 411
            ....:.|.:.....|.    :|.|.:|..:..|.:   |:.:|..|:  ||
  Rat   727 GFNEVAPLEWLRYFDE----KELELMLCGMQEIDM---SDWQKNAIY--RH 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	12/29 (41%)
		WW	103..132	CDD:278809	9/28 (32%)
		C2_Kibra	693..813	CDD:176062
Wwp2	NP_001099654.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988
		WW	302..331	CDD:278809
		WW	332..361	CDD:278809	4/22 (18%)
		WW	407..435	CDD:278809	11/28 (39%)
		WW	447..477	CDD:238122	10/29 (34%)
		HECTc	516..868	CDD:238033	54/303 (18%)
		HECTc	539..867	CDD:214523	48/280 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900