DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kibra and Nedd4l

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_038952600.1	Gene:	Nedd4l / 291553	RGDID:	735047	Length:	1259	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	107/505 - (21%)
Similarity:	179/505 - (35%)	Gaps:	148/505 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 QQQQQHTHHQQQQQHH--SDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPR-----DCYTKPQ 93
            |..|...::..:.||.  ..| ||.||::....:|:.::|||..|.|||.|||     ...:|..
  Rat   744 QSPQPSPYNSPKPQHKVTQSF-LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKAS 807

  Fly    94 TFEDCVGDELPMGWEESYDPNIGPYYINHLAQ------------------STQLEDPRQEWKTVQ 140
            ...:.:| .||.||||....:...:||:|.:|                  .||.||||     :|
  Rat   808 LNPNDLG-PLPPGWEERIHLDGRTFYIDHSSQVLCGENDTRESVPLYDSKITQWEDPR-----LQ 866

  Fly   141 EQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASRSSLCSSS--SSMSRHDPELL 203
            ...::   ..|.......::.:|..:::|....:..|..::...|:::...|  ..||...|::|
  Rat   867 NPAIT---GPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVL 928

  Fly   204 RADLML-------------ARERVHQLKQELTHITNDISYTERGMNTLYSVGE---------KIN 246
            :|.|.:             |||....|.:|:             .|..|.:.|         :||
  Rat   929 KARLWIEFESEKGLDYGGVAREWFFLLSKEM-------------FNPYYGLFEYSATDNYTLQIN 980

  Fly   247 ARENGCYD--------------IAEVHA-------IR---EEMLKVHKSLVSGEKVREELMRSLV 287
            .....|.:              :|..|.       ||   :.||....:|...|.|..|...||.
  Rat   981 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLK 1045

  Fly   288 QIKNELGRQQISEENSDLASPFDRVCV-------ASQTDLCGSSGENLNGGARFAEMAKTKWQY- 344
            .|        :..:.::|...|   |:       ..|.||       ...|:......:.|.:|
  Rat  1046 WI--------LENDPTELDLMF---CIDEENFGQTYQVDL-------KPNGSEIMVTNENKREYI 1092

  Fly   345 ---AEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVI 406
               .:|| .:.::|:|:...:|.... .|..|..:|....|.|.|:..|..:.:..
  Rat  1093 DLVIQWR-FVNRVQKQMNAFLEGFTE-LLPIDLIKIFDENELELLMCGLGDVDVND--------- 1146

  Fly   407 HQTRHKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALKSTKLLE 456
             ..:|.:   .|..|..|:..:    ::..:..||:|    |.|..:||:
  Rat  1147 -WRQHSI---YKNGYCPNHPVI----QWFWKAVLLMD----AEKRIRLLQ 1184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	14/34 (41%)
		WW	103..132	CDD:278809	13/46 (28%)
		C2_Kibra	693..813	CDD:176062
Nedd4l	XP_038952600.1	C2	<365..418	CDD:417471
		WW	463..489	CDD:395320
		WW	653..682	CDD:395320
		WW	766..796	CDD:238122	13/29 (45%)
		WW	815..865	CDD:197736	16/54 (30%)
		HECTc	926..1255	CDD:214523	59/313 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900