Protein Alignment kibra and Nedd4l

DIOPT Version :10

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_038952600.1
• Gene: Nedd4l / 291553
• RGDID: 735047
• Length: 1259
• Species: Rattus norvegicus
• Alignment Length: 505
• Identity: 107/505 - (21%)
• Similarity: 179/505 - (35%)
• Gaps: 148/505 - (29%)

  Fly    36 QQQQQHTHHQQQQQHH--SDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPR-----DCYTKPQ 93
            |..|...::..:.||.  ..| ||.||::....:|:.::|||..|.|||.|||     ...:|..
  Rat   744 QSPQPSPYNSPKPQHKVTQSF-LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKAS 807

  Fly    94 TFEDCVGDELPMGWEESYDPNIGPYYINHLAQ------------------STQLEDPRQEWKTVQ 140
            ...:.:| .||.||||....:...:||:|.:|                  .||.||||     :|
  Rat   808 LNPNDLG-PLPPGWEERIHLDGRTFYIDHSSQVLCGENDTRESVPLYDSKITQWEDPR-----LQ 866

  Fly   141 EQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASRSSLCSSS--SSMSRHDPELL 203
            ...::   ..|.......::.:|..:::|....:..|..::...|:::...|  ..||...|::|
  Rat   867 NPAIT---GPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVL 928

  Fly   204 RADLML-------------ARERVHQLKQELTHITNDISYTERGMNTLYSVGE---------KIN 246
            :|.|.:             |||....|.:|:             .|..|.:.|         :||
  Rat   929 KARLWIEFESEKGLDYGGVAREWFFLLSKEM-------------FNPYYGLFEYSATDNYTLQIN 980

  Fly   247 ARENGCYD--------------IAEVHA-------IR---EEMLKVHKSLVSGEKVREELMRSLV 287
            .....|.:              :|..|.       ||   :.||....:|...|.|..|...||.
  Rat   981 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLK 1045

  Fly   288 QIKNELGRQQISEENSDLASPFDRVCV-------ASQTDLCGSSGENLNGGARFAEMAKTKWQY- 344
            .|        :..:.::|...|   |:       ..|.||       ...|:......:.|.:|
  Rat  1046 WI--------LENDPTELDLMF---CIDEENFGQTYQVDL-------KPNGSEIMVTNENKREYI 1092

  Fly   345 ---AEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVI 406
               .:|| .:.::|:|:...:|.... .|..|..:|....|.|.|:..|..:.:..
  Rat  1093 DLVIQWR-FVNRVQKQMNAFLEGFTE-LLPIDLIKIFDENELELLMCGLGDVDVND--------- 1146

  Fly   407 HQTRHKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALKSTKLLE 456
             ..:|.:   .|..|..|:..:    ::..:..||:|    |.|..:||:
  Rat  1147 -WRQHSI---YKNGYCPNHPVI----QWFWKAVLLMD----AEKRIRLLQ 1184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	14/34 (41%)
		WW	103..132	CDD:459800	13/46 (28%)
		C2_Kibra	693..813	CDD:176062
Nedd4l	XP_038952600.1	C2	<365..418	CDD:472691
		WW	463..489	CDD:459800
		WW	653..682	CDD:459800
		WW	766..796	CDD:238122	13/29 (45%)
		WW	815..865	CDD:197736	16/54 (30%)
		HECTc	926..1255	CDD:214523	59/313 (19%)