DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and Hecw1

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_017455974.1	Gene:	Hecw1 / 291209	RGDID:	1561038	Length:	1603	Species:	Rattus norvegicus

Alignment Length:	931	Identity:	169/931 - (18%)
Similarity:	291/931 - (31%)	Gaps:	361/931 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 HHLRPQQQ----QQQHHHHHQQQQQQQHTHHQQQQQHHSDFPLPDGWDIAKDFDGKTYYIDHINK 78
            |:.:|..|    :.:|||:..                 .|.|||..|:...|..|:.:|:||:|:
  Rat   803 HNSQPISQLPSLRPEHHHYPT-----------------IDEPLPPNWEARIDSHGRVFYVDHVNR 850

  Fly    79 KTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKTVQ--- 140
            .|||..|....|             |.|...|     |..:        |:|...:.::.:|
  Rat   851 TTTWQRPSMAPT-------------PDGMIRS-----GSVH--------QMEQLNRRYQNIQRTI 889

  Fly   141 --EQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASRSSLCSSSSSMSRHDPELL 203
              |:...|..:.:.:|:.:..                      |....|...:.||.|..|   |
  Rat   890 ATERSEEDSGNQSCEQIPDGG----------------------AGGGGSDSEAESSQSNLD---L 929

  Fly   204 RADLMLA---RERVHQLKQE--LTHITNDISYTERGMNTLYSVGEKINARENGCYDIAEVHAIRE 263
            |.:..|:   .::|..|.|.  :..|||...:|....|  ||......:  :.|        ::.
  Rat   930 RREGSLSPVNSQKVTLLLQSPAVKFITNPEFFTVLHAN--YSAYRVFTS--STC--------LKH 982

  Fly   264 EMLKVHKSLVSGEKVREELMRSLVQIKN-------EL-----------GRQQISEENSDLASPFD 310
            .:|||.:...:.|:.:..  |.||...|       ||           |:....:.||...:..|
  Rat   983 MILKVRRDARNFERYQHN--RDLVNFINMFADTRLELPRGWEIKTDHQGKSFFVDHNSRATTFID 1045

  Fly   311 -RVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIEPGQLESDK 374
             |:.:        .:|...|              :...|:|:::|:...|.     |..::..::
  Rat  1046 PRIPL--------QNGRLPN--------------HLTHRQHLQRLRSYSAG-----EASEVSRNR 1083

  Fly   375 DRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVANRLRFHEEKQ 439
            ...||.:....|:..:.|               |.:|   |.|..||  |:..||    |..:..
  Rat  1084 GASLLARPGHSLIAAIRS---------------QHQH---ESLPLAY--NDKIVA----FLRQPN 1124

  Fly   440 L--LLDKLQEALKSTKLLEERLKSFSSESTF---SISSGSSLGSLSTASSKSALSFTDIYIDPFA 499
            :  :|.:.|.:|.....|.|::....:|...   .:|..:.|..|.:...:..:|:..:
  Rat  1125 IFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPL------ 1183

  Fly   500 VDSPIDVVDLRRRSQRLFQQHQQQRLHPVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGA 564
                                  |...||.:           :.|||.|     |.:||
  Rat  1184 ----------------------QSAFHPGY-----------SFSPRCS-----PCSSP------- 1203

  Fly   565 DQTPQALKEEPTYANALPAPPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKL----QKLNMG 625
                   :..|....|....|:               ||..|        .||||    :||. .
  Rat  1204 -------QNSPGLQRASARAPS---------------PYRRD--------FEAKLRNFYRKLE-A 1237

  Fly   626 TPLNLAVAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRK 690
            .........:..|..:..||:                               |.|....|: .||
  Rat  1238 KGFGQGPGKIKLIIRRDHLLE-------------------------------GTFNQVMAY-SRK 1270

  Fly   691 ELAQVQIGLKYLKQEGV----------LVVSLERANNLLALWTASADNS---QVYLRAALLPNSL 742
            ||.:.::.:.::.:||:          .::|.|..|....|:..||:::   |:...:|.:.|.|
  Rat  1271 ELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENYL 1335

  Fly   743 TSIR--TKALG-----------DFQKPVFNDTFAVPIT------LDKLLTKSLQ---------VT 779
            ...|  .:.||           .|.:|.:.....:|..      ||:...:|||         :.
  Rat  1336 EWFRFSGRILGLALIHQYLLDAFFTRPFYKGLLKLPCDLSDLEYLDEEFHQSLQWMKDNNITDIL 1400

  Fly   780 VVTMTGQKEEIIGTV----------QISMAEFNPE---DSTLKW-----------------YNVL 814
            .:|.| ..||:.|.|          ...:.|.|.:   :..:||                 |.|:
  Rat  1401 DLTFT-VNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVV 1464

  Fly   815 SSKFIPSFESLDIPSTSAAAA 835
            .|:.:..|::.::....|..|
  Rat  1465 DSRLVSVFDARELELVIAGTA 1485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	12/29 (41%)
		WW	103..132	CDD:278809	6/28 (21%)
		C2_Kibra	693..813	CDD:176062	34/190 (18%)
Hecw1	XP_017455974.1	HECW_N	66..185	CDD:293170
		C2_NEDL1-like	206..342	CDD:176073
		WW	827..857	CDD:197736	13/29 (45%)
		WW	1017..1048	CDD:197736	5/30 (17%)
		HECTc	1247..1601	CDD:238033	49/272 (18%)
		HECTc	1271..1600	CDD:214523	41/216 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900