DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and MAGI3

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001136254.1	Gene:	MAGI3 / 260425	HGNCID:	29647	Length:	1481	Species:	Homo sapiens

Alignment Length:	1433	Identity:	269/1433 - (18%)
Similarity:	449/1433 - (31%)	Gaps:	445/1433 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 QHHHHHQQQQQQQHTHHQQQQQHHS-DF-----------PLPDGWDIAKDFDGKTYYIDHINKKT 80
            ::...|.:......|.....|.:.| ||           |||..|::|....|..|:|||..|.|
Human   255 ENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNWEMAYTDTGMIYFIDHNTKTT 319

  Fly    81 TWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLS 145
            ||||||.| .|.:..|||...|||.|||:..||..|.||::||.|.||.|:|.:|.|. ::|:..
Human   320 TWLDPRLC-KKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKR-KKQLGQ 382

  Fly   146 DYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASRSSLCSSSSSMSRHDPELLRADLMLA 210
            ..:.:::..:|......|..|            ||....|:||..|:...         ...::.
Human   383 VEIGSSKPDMEKSHFTRDPSQ------------LKGVLVRASLKKSTMGF---------GFTIIG 426

  Fly   211 RERVHQLKQELTHITNDISYTERGMNTLYSVGEKINARENGCYDIAEVHAIREEMLK-------V 268
            .:|    ..|...:.|.:.......:...:.|:.|......|. :...||...:|.:       |
Human   427 GDR----PDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCV-LGHTHADVVQMFQLVPVNQYV 486

  Fly   269 HKSLVSGEKV---REELMRSLVQIKNELGRQQISEENSDLASPFD---RVCVASQTDLCGS--SG 325
            :.:|..|..:   .|:.:..:|.....:..|.:::..:.: :|.|   ...|..|....|.  :|
Human   487 NLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCM-NPQDFKPGAMVLEQNGKSGHTLTG 550

  Fly   326 ENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQ--------- 381
            :.|||.:..:|                       ..|.....|..:.:...|.||:
Human   551 DGLNGPSDASE-----------------------QRVSMASSGSSQPELVTIPLIKGPKGFGFAI 592

  Fly   382 ------EKEKLLNDLNSISLKSRSEEEKRVIHQT----RH------------------------- 411
                  :|.|::.|........:.:..|.:.||.    .|
Human   593 ADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGP 657

  Fly   412 -------KLEEDLKE---AYEANNTCVANRLRFH----EEKQLLLDKLQEALKSTKLLEER---- 458
                   |::.|.||   :.||.|..:...:.|.    ......||..:..|||..|.|::
Human   658 PSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNT 722

  Fly   459 ------LKSFSSESTFSISSGSS------LGS---LSTASSKSALSFTD--IYID--PFAVDSPI 504
                  |:...|...|.:..|..      :|:   |..|.....|...|  :.||  |....|..
Human   723 KDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHK 787

  Fly   505 DVVDLRRRSQR-----------LFQQHQQQRLHPVHPVLQQQQSAEVTLSPRSSLSMETPPASPM 558
            .|:||...:.|           :|...:|.........:..|..     |||  |:....||.|
Human   788 QVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNG-----SPR--LNRAEVPARP- 844

  Fly   559 KYNAGADQTPQAL----KEEPTYANALPAPPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKL 619
                 |.|.|..:    ||...:...:..  :...|||    ||                :..|:
Human   845 -----APQEPYDVVLQRKENEGFGFVILT--SKNKPPP----GV----------------IPHKI 882

  Fly   620 QKLNMGTPLN----LAVAPLSPISEKPSLLDLPQEML---------------------------- 652
            .::..|:|.:    |.|..........|:::|..:.:
Human   883 GRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGT 947

  Fly   653 --SRSSSTSNTRSVSAAVSNESVAGDSGVFE---------------ASRAHLPRKELAQVQ-IGL 699
              :|.|.....|.:..:.:|. :.||....|               :...||.:.:.|.:. :|.
Human   948 NSARQSPALQHRPMGQSQANH-IPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGS 1011

  Fly   700 KYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSLTSIRTKALGDFQKPVFNDTFAV 764
            ::.:..|...|.|||................:.|....|.....:|:     |.:..|.:....:
Human  1012 RHNQNLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIK-----DGRIHVGDQIVEI 1071

  Fly   765 PITLDKLLTKSLQVTVVTMTGQKEEII-----------GTVQISMAEFNPEDSTLKWYNVL---- 814
            .....:.:|.:..:.::...|.|..::           |...|:    ||..|     ||:
Human  1072 NGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDIN----NPSSS-----NVIYDEQ 1127

  Fly   815 -----SSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQTSTLTRNQAP 874
                 ||.|...||...:|....:......            |::.:...|...:.|||..||.
Human  1128 SPLPPSSHFASIFEESHVPVIEESLRVQIC------------EKAEELKDIVPEKKSTLNENQP- 1179

  Fly   875 CMELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSSMLHAYLQNMKQEFA 939
              |::.|         .|.:...|..|........:.|.|:.   :.|..:.....:...|....
Human  1180 --EIKHQ---------SLLQKNVSKRDPPSSHGHSNKKNLLK---VENGVTRRGRSVSPKKPASQ 1230

  Fly   940 DKETNTDRAYLPEKSRGQSQLMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHT 1004
            ..|.:.|:...|.|:..:.     ||  |.|:.:||:..:|   :|:::.........|
Human  1231 HSEEHLDKIPSPLKNNPKR-----RP--RDQSLSPSKGENK---SCQVSTRAGSGQDQC------ 1279

  Fly  1005 FQRGAAERRSLRFHSKAPKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQ 1069
                    |..|..|.:||...|:..:..|                    ::..|||
Human  1280 --------RKSRGRSASPKKQQKIEGSKAP--------------------SNAEAKL-------- 1308

  Fly  1070 KACENKDPLVAAWAIENEEFQRLVARADPAKCPEERQLQKLLMKTAKEIHKLRKTKVPKGCPDLV 1134
              .|.|...:|.:...|.|           :.|:.::...::.|.||: ::|.|::..
Human  1309 --LEGKSRRIAGYTGSNAE-----------QIPDGKEKSDVIRKDAKQ-NQLEKSRTR------- 1352

  Fly  1135 SFKEKITFFTRKGLSVPELPSEFTLPEANPIEEEEEEEDENEFYNSAETAIAINTALVASSN--- 1196
            |.::||.....|     .|||:.|    |....:|..|:|.        ...:.|...:|||
Human  1353 SPEKKIKRMVEK-----SLPSKMT----NKTTSKEVSENEK--------GKKVTTGETSSSNDKI 1400

  Fly  1197 ------RNKNLSEHP----------------------HRATSGAVPKIPAPVVTPAATPAATPAA 1233
                  ..|.|.:.|                      ::.|....|:..:||.....||.  |..
Human  1401 GENVQLSEKRLKQEPEEKVVSNKTEDHKGKELEAADKNKETGRFKPESSSPVKKTLITPG--PWK 1463

  Fly  1234 TPA 1236
            .|:
Human  1464 VPS 1466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	15/29 (52%)
		WW	103..132	CDD:278809	16/28 (57%)
		C2_Kibra	693..813	CDD:176062	20/131 (15%)
MAGI3	NP_001136254.1	Interaction with ADRB1 and TGFA. /evidence=ECO:0000250	18..106
		PDZ_signaling	24..101	CDD:238492
		NK	123..>197	CDD:327404
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..273		2/17 (12%)
		WW	294..326	CDD:197736	17/31 (55%)
		WW	342..372	CDD:238122	16/29 (55%)
		Interaction with PTEN. /evidence=ECO:0000269\|PubMed:10748157	410..492		15/95 (16%)
		PDZ	413..493	CDD:214570	13/93 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..570		7/50 (14%)
		PDZ	575..656	CDD:214570	10/80 (13%)
		Interaction with ADGRB1. /evidence=ECO:0000269\|PubMed:10748157	726..808		17/81 (21%)
		PDZ_signaling	726..807	CDD:238492	17/80 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..843		6/28 (21%)
		PDZ_signaling	849..935	CDD:238492	15/107 (14%)
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000269\|PubMed:10748157, ECO:0000269\|PubMed:16904289	851..938		14/108 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..976		6/37 (16%)
		PDZ_signaling	1022..1100	CDD:238492	12/82 (15%)
		Red1	<1132..1461	CDD:311769	81/447 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1170..1481		75/404 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900